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J Psychopharmacol ; 38(6): 541-550, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38863284

RESUMO

BACKGROUND: Alcohol use disorder (AUD) is a major public health issue, posing harmful consequences for individuals and society. Recent advances in addiction research have highlighted the therapeutic potential of ketamine-assisted therapy for AUD. However, the exact mechanisms underlying its effectiveness remain unknown. AIMS: This double-blind, pilot study aimed to investigate esketamine combined with mindfulness-based intervention (MBI) to examine whether esketamine enhances engagement in MBI for individuals with alcohol misuse problems and whether enhanced engagement has any impact on alcohol-related outcomes. METHODS: In all, 28 individuals with alcohol problems were randomly assigned to receive sublingual esketamine hydrochloride (AWKN002: 115.1 mg) or vitamin C (placebo) in an oral thin film and took part in 2 weeks of daily MBI. Participants were assessed on various self-report measures, including mindfulness, engagement in MBI (physical and psychological), alcohol cravings and consumption. RESULTS: Esketamine enhanced psychological engagement with a daily MBI, compared to placebo, and led to transient decreases in alcohol cravings. Esketamine also resulted in significantly greater mystical experiences and dissociative states compared to placebo. CONCLUSIONS: The findings suggest that esketamine may improve treatment outcomes when combined with mindfulness-based therapies through its ability to increase engagement with meditative practice.


Assuntos
Alcoolismo , Fissura , Ketamina , Atenção Plena , Humanos , Ketamina/administração & dosagem , Ketamina/farmacologia , Atenção Plena/métodos , Masculino , Método Duplo-Cego , Feminino , Adulto , Alcoolismo/tratamento farmacológico , Alcoolismo/terapia , Projetos Piloto , Pessoa de Meia-Idade , Fissura/efeitos dos fármacos , Terapia Combinada , Resultado do Tratamento
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