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1.
Surg Endosc ; 38(4): 1813-1822, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38302757

RESUMO

INTRODUCTION: Limitations to surgical education access were exacerbated during the COVID-19 Pandemic. In response, we created a national home-based comprehensive surgical skills course: Monash Online Surgical Training (MOST). Our aim was to evaluate the educational impact of this approach. METHODS: A remote, 6-week course was designed with learning objectives aligned to the national surgical training. Participants received a personal laparoscopic bench trainer, instrument tracking software, live webinars, access to an online theoretical learning platform, and individualised feedback by system-generated or expert surgeons' assessments. Mixed method analysis of instrument tracking metrics, pre- and post-course questionnaires (11 core surgical domains) and participant comments was utilised. Data were analysed using the Mann-Whitney U test, and a p-value of < 0.05 was considered statistically significant. RESULTS: A total of 54 participants with varied levels of experience (1 to > 6 years post-graduate level) completed MOST. All 11 learning-outcome domains demonstrated statistically significant improvement including core laparoscopic skills (1.4/5 vs 2.8/5, p < 0.0001) and handling laparoscopic instruments (1.5/5 vs 2.8/5, p < 0.0001). A total of 3460 tasks were completed reflecting 158.2 h (9492 min) of practice, 394 were submitted for formal feedback. Participants rated the course (mean 8.5/10, SD 1.6), live webinars (mean 8.9/10, SD 1.6) and instrument tracking software (mean 8.6, SD 1.7) highly. Qualitative analysis revealed a paradigm shift including the benefits of a safe learning environment and self-paced, self-directed learning. CONCLUSION: The MOST course demonstrates the successful implementation of a fully remote laparoscopic simulation course which participants found to be an effective tool to acquire core surgical skills.


Assuntos
Laparoscopia , Treinamento por Simulação , Humanos , Pandemias , Laparoscopia/educação , Aprendizagem , Educação de Pós-Graduação em Medicina/métodos , Currículo , Treinamento por Simulação/métodos , Competência Clínica
2.
ANZ J Surg ; 93(11): 2600-2608, 2023 11.
Artigo em Inglês | MEDLINE | ID: mdl-37668263

RESUMO

BACKGROUND: Surgery is constantly evolving with the assistance of rapidly developing novel technology. Eye-tracking devices provide opportunities to monitor the acquisition of surgical skills, gain insight into performance, and enhance surgical practice. The aim of this review was to consolidate the available evidence for the use of eye-tracking in the surgical disciplines. METHODS: A systematic literature review was conducted in accordance with PRISMA guidelines. A search of OVID Medline, EMBASE, Cochrane library, Scopus, and Science Direct was conducted January 2000 until December 2022. Studies involving eye-tracking in surgical training, assessment and technical innovation were included in the review. Non-surgical procedures, animal studies, and studies not involving surgical participants were excluded from the review. RESULTS: The search returned a total of 12 054 articles, 80 of which were included in the final analysis and review. Seventeen studies involved eye-tracking in surgical training, 48 surgical assessment, and 20 were focussing on technical aspects of this technology. Twenty-six different eye-tracking devices were used in the included studies. Metrics such as the number of fixations, duration of fixations, dwell time, and cognitive workload were able to differentiate between novice and expert performance. Eight studies demonstrated the effectiveness of gaze-training for improving surgical skill. CONCLUSION: The current literature shows a broad range of utility for a variety of eye-tracking devices in surgery. There remains a lack of standardization for metric parameters and gaze analysis techniques. Further research is required to validate its use to establish reliability and create uniform practices.


Assuntos
Competência Clínica , Tecnologia de Rastreamento Ocular , Humanos , Reprodutibilidade dos Testes , Carga de Trabalho , Tecnologia
3.
ANZ J Surg ; 92(5): 1153-1158, 2022 05.
Artigo em Inglês | MEDLINE | ID: mdl-35393697

RESUMO

BACKGROUND: Our aims were to determine if the diagnostic threshold for diagnosing hypertrophic pyloric stenosis (HPS) on ultrasound scan (USS) should be adjusted based on birth weight (BW), current weight (CW), gestational age (GA), chronological age (CA) or corrected gestational age (CGA). METHODS: All patients who underwent either an USS and pyloromyotomy (Group 1) or an USS for possible HPS (Group 2) at our tertiary centre between July 2013 and June 2019 were identified. Ideal threshold values are identified by measuring Youden's Index (J = sensitivity + specificity - 1; higher is better). Mean maximum Youden's Index for stratified results was compared to that for combined results. RESULTS: Two hundred and eighty-four patients were included (142 patients in both Group 1 and Group 2). Combined maximum Youden's Index for all patients was 0.92 for pyloric canal thickness (PMT) and 0.87 for pyloric canal length (PCL). Mean maximum Youden's Index was higher when patients were stratified by GA, CGA, BW or CW, and equivalent for CA. For pyloric canal length (PCL), mean maximum Youden's Index was lower for all variables when stratified compared to combined. There was no visual trend observed in the diagnostic thresholds between groups. CONCLUSION: Stratifying USS PMT diagnostic thresholds values based on age and weight is statistically more accurate than a single threshold in diagnosing HPS. However, the lack of visual correlation indicates a larger dataset is required to validate these results.


Assuntos
Estenose Pilórica Hipertrófica , Piloromiotomia , Constrição Patológica , Humanos , Lactente , Estenose Pilórica Hipertrófica/diagnóstico por imagem , Estenose Pilórica Hipertrófica/cirurgia , Piloro/diagnóstico por imagem , Ultrassonografia
4.
ANZ J Surg ; 91(11): 2507-2513, 2021 11.
Artigo em Inglês | MEDLINE | ID: mdl-34608732

RESUMO

BACKGROUND: Our aims were to evaluate the ultrasound scan (USS) criteria in diagnosing hypertrophic pyloric stenosis (HPS), determine the best diagnostic threshold values for pyloric muscle thickness (PMT) and pyloric canal length (PCL), and assess the accuracy of flow through the pylorus. METHODS: All patients who underwent pyloromyotomy at our tertiary paediatric surgery centre between July 2013 and June 2019 were identified (Group 1). All patients undergoing an USS to investigate for a possible HPS and did not undergo pyloromyotomy were also identified (Group 2). Accuracy was determined by Youden's Index (J) with the highest J determining the ideal cut-off value. RESULTS: Two hundred and eighty-four patients (142 patients in each group) were included in the analysis. Using only the last USS before surgery, PMT provided an area under the curve (AUC) of 0.987 (n = 275), and PCL an AUC of 0.977 (n = 267). Ideal threshold values were 3.0 mm for PMT (J = 0.92), and 14.5 mm for PCL (J = 0.87). Combining PMT ≥3.0 mm with a PCL ≥14.5 mm resulted in a sensitivity of 95% and specificity of 99% (J = 0.94). The absence of flow through the pylorus on dynamic USS provided a sensitivity of 99% and specificity of 91% (J = 0.91; n = 277). CONCLUSION: Combining threshold values of 3.0 mm for PMT and 14.5 mm PCL provides the highest accuracy for diagnosing pyloric stenosis on an ultrasound scan. These combined values were more accurate than observing for the absence of flow through the pylorus.


Assuntos
Estenose Pilórica Hipertrófica , Piloromiotomia , Criança , Estudos Transversais , Humanos , Hipertrofia , Lactente , Estenose Pilórica Hipertrófica/diagnóstico por imagem , Estenose Pilórica Hipertrófica/cirurgia , Piloro/diagnóstico por imagem , Piloro/cirurgia , Ultrassonografia
5.
World J Surg ; 44(12): 3986-3992, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32920705

RESUMO

PURPOSE: To estimate proportion of Myanmar paediatric population at risk of impoverishment and catastrophic expenditure due to emergency surgical intervention. METHODS: Prospective data were collected at two tertiary surgical centres including income, household expenses, expenses related to surgery. Data analysis was performed to estimate out-of-pocket (OOP) direct medical costs and OOP total costs. Catastrophic expenditure: expense exceeded 10% of household income. Risk of impoverishment: net income drops were below an impoverishment threshold (PPP-purchasing power parity): I$ 2.00 PPP/day, I$ 1.25/day PPP, national poverty line. Distribution of income was estimated using a gamma distribution. Comparison to an adult cohort was performed using Chi-square test with a p value of <0.05 being significant. RESULTS: A total of 145 surveys were collected, and 119 (82.1%) contained sufficient data: Paediatric Centre (n = 99) and Adult Centre (n = 20). Overall average per patient direct medical and non-medical OOP costs was I$493: Centre 1: I$540 PPP (range I$41-6,588 PPP) and Centre 2: I$437 PPP (range I$ 36-1,405 PPP). 64% experienced catastrophic expense. There is no significant difference between the centres in the risks of impoverishment or catastrophic expenditure (p = 0.05). Up to 44% are at risk of catastrophic expenditure should surgery be required. Most of the risk (90%) is derived from direct non-medical costs. A high proportion were at the national poverty line threshold (36.1%). Seeking surgical treatment would imperil up to 37% at the national poverty line threshold, and up to 5.7% at the I$2 PPP per day limit. CONCLUSIONS: A large proportion of the Myanmar population are at risk of impoverishment or catastrophic expenditure should they require surgery. Financial risk protection mechanisms are needed.


Assuntos
Doença Catastrófica/economia , Financiamento Pessoal/estatística & dados numéricos , Gastos em Saúde/estatística & dados numéricos , Política de Saúde/economia , Pobreza/estatística & dados numéricos , Adulto , Criança , Características da Família , Feminino , Financiamento Pessoal/economia , Humanos , Mianmar , Gravidez , Estudos Prospectivos , Fatores de Risco
8.
Simul Healthc ; 15(1): 7-13, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31743311

RESUMO

INTRODUCTION: Pediatric intussusception is a common cause of bowel obstruction in infants. Air enema (AE) reduction is routine first-line management in many countries; however, there is a high rate of operative intervention in low- and middle-income countries. The aims of the study were to use simulation-based medical education with an intussusception simulator to introduce AE reduction to Myanmar and to assess its effect on provider behaviors and the resulting clinical care. METHODS: Clinical evaluation was conducted by comparing clinical outcomes data for children with intussusception 12 months before implementation with that from 12 months subsequent to implementation. These included the following: AE success rates, recurrence rates, length of stay, intestinal resection, and operative intervention rates. An educational workshop was developed that used a low-cost mannequin to facilitate practice at the reduction of intussusception using AE. Curriculum evaluation was performed through 5-point rating scale self-assessment in several domains. Data analysis was performed with Mann-Whitney U test, Student t test, or Wilcoxon signed-ranks test as appropriate; a P value of less than 0.05 was considered to be significant. RESULTS: After implementation, there was a significant reduction in the overall operative intervention rates [82.5% (85/103) vs. 58.7% (44/75), P = 0.006]. Intestinal resection rates increased [15.3% (13/85) vs. 35.9% (14/39), P = 0.02]. The success rate with attempted AE reduction was 94.4% (34/36), with a recurrence rate of 5.6% (2/36). The simulation-based medical education workshop was completed by 25 local participants. There was a significant difference in the confidence of performing (1.9 vs. 3.6, P ≤ 0.0001) or assisting (2.8 vs. 3.7, P = 0.018) an AE reduction before and after the workshop. CONCLUSIONS: Simulation-based educational techniques can be successfully applied in a low- and middle-income country to facilitate the safe introduction of new equipment and techniques with significant beneficial impact on provider behaviors and the resulting clinical care.


Assuntos
Educação Médica/métodos , Enema/métodos , Doenças do Íleo/terapia , Intussuscepção/terapia , Treinamento por Simulação/métodos , Criança , Pré-Escolar , Custos e Análise de Custo , Países em Desenvolvimento , Enema/economia , Feminino , Humanos , Masculino , Mianmar
9.
J Pediatr Surg ; 55(8): 1475-1480, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31753612

RESUMO

The study involves the testing of a novel laparoscopic training model by surgeons of various levels of experience. BACKGROUND: There has been an increasing requirement for low-cost simulation. Our aim was to evaluate the construct validity of a low-cost model for teaching core laparoscopic skills. METHODS: The Double-Glove model was made from 2 latex gloves, one placed in the other. The inner glove was filled with water and 3 ovals were drawn on the outer glove. Participants were required to dissect the middle oval out without perforating the inner glove or leaving the line border of the middle oval. The task was assessed using a previously validated scoring system (minimum -120; maximum 80). RESULTS: Ninety-five participants completed the task: 40 novices, 45 intermediates, and 10 experts. The model revealed statistical significance between the three groups. Experts scored higher than novices (58/80 vs 11.7/80; p < 0.0001) and intermediates (58/80 vs 29.1/80; p = 0.0004), and intermediates scored higher than novices (29.1/80 vs 11.7/80; p = 0.014). Novices took more time to complete the task compared to intermediates (10 min vs 7.87 min; p < 0.0001) and experts (10 min vs 6.98 min; p < 0.0001). No correlation between time taken and score obtained was seen (r = -0.06, r = 0.01, r = -0.2 for novice, intermediate, and expert groups). CONCLUSION: By differentiating between groups of variable experience, the model demonstrated construct validity. It offers an inexpensive model that can be utilized in low-cost laparoscopic simulation. TYPE OF STUDY: Study of a diagnostic test. LEVEL OF EVIDENCE: II.


Assuntos
Laparoscopia/educação , Treinamento por Simulação/métodos , Cirurgiões/educação , Humanos , Treinamento por Simulação/economia
10.
Comput Methods Programs Biomed ; 187: 105234, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31794913

RESUMO

BACKGROUND AND OBJECTIVE: Surgical skill assessment aims to objectively evaluate and provide constructive feedback for trainee surgeons. Conventional methods require direct observation with assessment from surgical experts which are both unscalable and subjective. The recent involvement of surgical robotic systems in the operating room has facilitated the ability of automated evaluation of the expertise level of trainees for certain representative maneuvers by using machine learning for motion analysis. The features extraction technique plays a critical role in such an automated surgical skill assessment system. METHODS: We present a direct comparison of nine well-known feature extraction techniques which are statistical features, principal component analysis, discrete Fourier/Cosine transform, codebook, deep learning models and auto-encoder for automated surgical skills evaluation. Towards near real-time evaluation, we also investigate the effect of time interval on the classification accuracy and efficiency. RESULTS: We validate the study on the benchmark robotic surgical training JIGSAWS dataset. An accuracy of 95.63, 90.17 and 90.26% by the Principal Component Analysis and 96.84, 92.75 and 95.36% by the deep Convolutional Neural Network for suturing, knot tying and needle passing, respectively, highlighted the effectiveness of these two techniques in extracting the most discriminative features among different surgical skill levels. CONCLUSIONS: This study contributes toward the development of an online automated and efficient surgical skills assessment technique.


Assuntos
Competência Clínica , Aprendizado Profundo , Cirurgia Geral/educação , Redes Neurais de Computação , Procedimentos Cirúrgicos Robóticos , Algoritmos , Automação , Benchmarking , Análise por Conglomerados , Bases de Dados Factuais , Educação de Pós-Graduação em Medicina , Humanos , Aprendizado de Máquina , Análise de Componente Principal , Reprodutibilidade dos Testes , Cirurgia Assistida por Computador/educação , Suturas
11.
J Laparoendosc Adv Surg Tech A ; 29(10): 1276-1280, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31381468

RESUMO

Introduction: We report the results of video-assisted thoracoscopic surgery (VATS) in a large population of children with empyema, focusing on the factors affecting the postoperative length of stay (LOS). Materials and Methods: After ethical approval (RES-18-0000-071Q), a retrospective review was performed (2013-2018). Results are reported as number of cases (%) and median (range) and analyzed by Mann-Whitney U and Kruskal-Wallis tests. Correlation analysis was conducted. Results: We identified 159 children with empyema; 75 [42 (56%) males] underwent VATS. Median age was 3.6 (0.4-14.5) years. Presentation was: autumn 15 (20%), winter 26 (35%), spring 18 (24%), summer 16 (21%) with no difference in LOS (P = .6). Preoperative symptoms duration was 7 (2-28) days. Postoperatively, chest drain was on suction in 30 (40%) patients, in situ for 3 (2-13) days. Six (8%) children required further procedures. LOS was 8 (3-47) days. Pleural fluid revealed: Streptococcus species. 41 (55%), other species 8 (11%), no bacteria 26 (34%); LOS was longer with positive pleural fluid: 9 (4-47) versus 6.5 (3-16) days (P = .02). There was no correlation between the LOS and preoperative symptoms duration (r = -0.03 [95% CI -0.3 to 0.2]; P = .7), empyema size (r = 0.2 [95% CI -0.07 to 0.5]; P = .1) and chest drain size (r = 0.09 [95% CI -0.14 to 0.3]; P = .4). Discussion: In our experience, >90% of children with empyema will be treated with a single VATS with an average LOS of 8 days. Positive microbiology culture significantly affects the LOS.


Assuntos
Empiema Pleural/cirurgia , Tempo de Internação/estatística & dados numéricos , Cirurgia Torácica Vídeoassistida , Adolescente , Criança , Pré-Escolar , Empiema Pleural/diagnóstico por imagem , Feminino , Seguimentos , Humanos , Lactente , Masculino , Estudos Retrospectivos , Centros de Atenção Terciária , Resultado do Tratamento
12.
Comput Methods Programs Biomed ; 177: 1-8, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31319938

RESUMO

BACKGROUND AND OBJECTIVES: Currently, the assessment of surgical skills relies primarily on the observations of expert surgeons. This may be time-consuming, non-scalable, inconsistent and subjective. Therefore, an automated system that can objectively identify the actual skills level of a junior trainee is highly desirable. This study aims to design an automated surgical skills evaluation system. METHODS: We propose to use a deep neural network model that can analyze raw surgical motion data with minimal preprocessing. A platform with inertial measurement unit sensors was developed and participants with different levels of surgical experience were recruited to perform core open surgical skills tasks. JIGSAWS a publicly available robot based surgical training dataset was used to evaluate the generalization of our deep network model. 15 participants (4 experts, 4 intermediates and 7 novices) were recruited into the study. RESULTS: The proposed deep model achieved an accuracy of 98.2%. With comparison to JIGSAWS; our method outperformed some existing approaches with an accuracy of 98.4%, 98.4% and 94.7% for suturing, needle-passing, and knot-tying, respectively. The experimental results demonstrated the applicability of this method in both open surgery and robot-assisted minimally invasive surgery. CONCLUSIONS: This study demonstrated the potential ability of the proposed deep network model to learn the discriminative features between different surgical skills levels.


Assuntos
Competência Clínica , Redes Neurais de Computação , Procedimentos Cirúrgicos Robóticos/educação , Cirurgiões , Acelerometria , Adulto , Algoritmos , Calibragem , Feminino , Humanos , Laparoscopia , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Minimamente Invasivos , Movimento (Física) , Movimento , Suturas , Adulto Jovem
13.
Paediatr Respir Rev ; 30: 42-48, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31130425

RESUMO

BACKGROUND: The ideal surgical approach for empyema in children (≤18 years) remains controversial. Video assisted thoracoscopic surgery (VATS) and chest drain with fibrinolysis (CDF) are both accepted methods. The aim of this study was to clarify which of these two techniques provides the best clinical outcome. METHODS: A systematic review and meta-analysis (1997-2018) was conducted. We used the random-effect model to produce risk ratio (RR) for categorical variables, and standard difference in means (SDM) for continuous variables, along with 95% confidence intervals [CI]. I2 value was used to assess heterogeneity. P values <0.05 were considered significant. RESULTS: We identified 707 studies: 10 studies were included in the final analysis. The incidence of total peri-operative complications was not different between the two groups (RR 0.6 [CI: 0.3-1.2], p = 0.2; I2 = 0.0%; p = 0.6). Need for re-intervention was significantly lower in the VATS group (RR 0.55 [CI: 0.34-0.88], p = 0.01; I2 = 14.4%; p = 0.3). Post-operative length of hospital stay was significantly shorter in the VATS group (SDM -0.45 [CI: -0.78 to -0.12], p = 0.007; I2 = 88%; p = 0.001). CONCLUSIONS: Current evidence suggests that VATS and CDF for empyema in children have a similar incidence of peri-operative complications. However, VATS seems associated with reduced need for re-intervention and shorter post-operative hospital stay.


Assuntos
Empiema Pleural/terapia , Fibrinolíticos/uso terapêutico , Toracentese/métodos , Cirurgia Torácica Vídeoassistida/métodos , Tubos Torácicos , Criança , Humanos
14.
Pediatr Surg Int ; 35(4): 419-423, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30607542

RESUMO

PURPOSE: To define the practice of management for Hirschsprung disease (HD) in Australia and New Zealand. METHODS: Online survey of Australian and New Zealand Association of Paediatric Surgeons (ANZAPS) members. RESULTS: 56/80 (70%) members from 17 centres responded. DIAGNOSIS: 100% perform suction rectal biopsies; 40% perform a contrast enema. HISTOPATHOLOGICAL STAINING: H&E (94%), ACHE (70%) and calretinin (75%). SURGERY: Primary pull-through (PT) is performed by 88% (100% by < 6/12 months). The Soave-Boley PT is the preferred approach (85%), with laparoscopic assistance (77%) and muscle cuff division (93%). Routine post-operative dilatations are performed by 63% of respondents. If symptoms persist following PT, majority adopt a conservative approach (enemas/laxatives 90%; Botox 74%). If a long-segment is identified at PT, 60% fashion a stoma and delay definitive surgery. If total colonic aganglionosis is identified at PT, 76% fashion a stoma and delay definitive surgery. A dedicated bowel management program is available in 45% of centres with transition to adult services in 29%. CONCLUSIONS: A laparoscopic-assisted Soave-Boley PT is the most common technique for recto-sigmoid HD. Differences are noted in both the management of long-segment/total aganglionosis HD and post-operative management/follow-up.


Assuntos
Procedimentos Cirúrgicos do Sistema Digestório/métodos , Gerenciamento Clínico , Doença de Hirschsprung/cirurgia , Sociedades Médicas , Cirurgiões/estatística & dados numéricos , Inquéritos e Questionários , Austrália/epidemiologia , Criança , Feminino , Doença de Hirschsprung/epidemiologia , Humanos , Lactente , Masculino , Morbidade , Nova Zelândia/epidemiologia
15.
Pediatr Surg Int ; 34(3): 353-361, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29124402

RESUMO

There is no consensus in the literature about the necessity for excision of testicular remnants in the context of surgery for an impalpable testis and testicular regression syndrome (TRS). The incidence of germ cells (GCs) within these nubbins varies between 0 and 16% in previously published series. There is a hypothetical potential future malignancy risk, although there has been only one previously described isolated report of intratubular germ-cell neoplasia. Our aim was to ascertain an accurate incidence of GCs and seminiferous tubules (SNTs) within excised nubbins and hence guide evidence-based practice. The systematic review protocol was designed according to the PRISMA guidelines, and subsequently published by the PROSPERO database after review (CRD42013006034). The primary outcome measure was the incidence of GCs and the secondary outcome was the incidence of SNTs. The comprehensive systematic review included articles published between 1980 and 2016 in all the relevant databases using specific search parameters and terms. Strict inclusion and exclusion criteria were ultilised to identify articles relevant to the review questions. Twenty-nine paediatric studies with a total of 1455 specimens were included in the systematic review. The mean age of the patients undergoing nubbin resection was 33 months and the TRS specimen was more commonly excised from the left (68%). The incidence of SNTs was 10.7% (156/1455) and the incidence of GCs, 5.3% (77/1455). Histological analysis excluding the presence of either SNTs or GCs was consistent with TRS, fibrosis, calcification or haemosiderin deposits. There is limited evidence on subset analysis that GCs and SNTs may persist with increasing patient age. This systematic review has identified that 1 in 20 of resected testicular remnants has viable GCs and 1 in 10 has SNTs present. There is insufficiently strong evidence for the persistence of GCs and SNTs with time or future malignant potential. Intra-abdominal TRS specimens may contain more elements and, therefore, require excision, although this is based on limited evidence. However, there is no available strong evidence to determine that a TRS specimen requires routine excision in an inguinal or scrotal position.


Assuntos
Células Germinativas/citologia , Disgenesia Gonadal 46 XY/patologia , Túbulos Seminíferos/patologia , Testículo/anormalidades , Criptorquidismo/patologia , Criptorquidismo/cirurgia , Disgenesia Gonadal 46 XY/cirurgia , Humanos , Masculino , Testículo/patologia , Testículo/cirurgia
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