RESUMO
The infrared spectral region beyond 1.7 µm is of utmost interest for biomedical applications due to strong overtone and combination absorption bands in a variety of important biomolecules such as lactates, urea, glucose, albumin, etc. In this article, we report on recent progress in widely tunable swept-wavelength lasers based on type-I GaSb gain-chip technology, setting a new state-of-the-art in the 1.7 - 2.5 µm range laser sources. We provide an application example for the spectroscopic sensing of several biomolecules in a cuvette as well as an experimental demonstration of a non-invasive in-vivo sensing of human serum albumin through the skin.
RESUMO
A refractive index sensor with a free spectral range that is unlimited by neighboring mode spacing (10 fold increase with respect to 20 nm of an unmodified ring), based on an optical silicon-on-insulator microring resonator patterned with periodically arranged set of gold nanodisks, is presented and numerically verified. It is shown that the particular periodic arrangement of nanodisks selects a single resonance from a wide set of ring resonator modes and removes mode splitting. Extraction of the waveguided electromagnetic energy into evanescent plasmonic modes enhances light-analyte interaction and increases device sensitivity to variation of refractive index up to 176 nm/RIU (about 2-fold increase compared to the unmodified ring), which is useful for sensor applications. Proof of the concept is presented by finite-difference time-domain simulations of a design readily practicable by means of modern nanotechnology.
