Biosynthesis of phyto functionalized cerium oxide nanoparticles mediated from Scoparia dulsis L. for appraisal of anti-cancer potential against adenocarcinomic lung cancer cells and paracetamol sensing potentiality.

This research work aims at the eco-friendly preparation of cerium oxide nanoparticles (CeSD NPs) utilizing the natural extract of Scoparia dulsis L. An attempt was made to analyze the influence of the fuel load on the size, shape, and optical properties of the nanoparticles. The p-XRD studies revealed the controlled formation of NPs with a size not more than 12.74 nm. The surface area studies appraise the mesoporous nature of the synthesized ceria particles, with the maximum specific surface area of 36.06 m2g-1. The nano-regime CeO2 nanoparticles had a definite impact on biomedical and electrochemical studies. The CeSD NPs with minuscule size (10.69 nm) manifested promising antioxidant and human RBC protection activity. The antioxidant properties were evaluated using % DPPH inhibition with of maximum of 83.38. The stabilization of RBC's by CeSD NPs was maximum at 94.97%. However, the CeSD NPs with apparent size (12.74 nm) that utilized greater volume fuel (25 mL) had noticeable results on adenocarcinomic lung (A549) cancer cell viability and antidiabetic study which was maximum of 70.16% at concentration 500 µg/mL. A satisfactory antibacterial application was proffered against chosen bacterial stains. The smallest size CeO2 NPs exhibited the best proton diffusion coefficient (8.16 × 10-6 cm2s-1), and the capacitance values of the CeSD NPs are near in all samples (~ 1.17 to 2.00 F) manifest their compact nano-regime sizes. The paracetamol drug was chosen as analyte to appreciating the superlative efficiency for sensing paracetamol drug with the lowest detection limit.

Effects of reinforcement of sodium alginate functionalized halloysite clay nanotubes on thermo-mechanical properties and biocompatibility of poly (vinyl alcohol) nanocomposites.

In the present work sodium alginate functionalized halloysite nanotubes (HNTs) reinforced poly (vinyl alcohol) nanocomposite films were prepared by solution casting technique. Sodium alginate surface functionalizing on the HNTs through hydrogen bonding was confirmed by spectroscopic and morphological analysis. The functionalized HNTs were successfully incorporated into the PVA matrix. Further, the films were characterized by using FTIR, TGA, XRD, SEM, AFM, UTM, WCA and swelling ratio analysis. The obtained results indicated improved physico-thermal properties, and uniform distribution of nanotubes in the matrix and roughness of the surface compared with the pristine PVA films. After inclusion of functionalized nanotubes causes enhancement of tensile strength as well as young's modulus of the nanocomposite films. Water contact angle measurement was carried out to know the hydrophilic or hydrophobic nature of the films and results were correlated with swelling ratio analysis. Furthermore, the films were analyzed for in-vitro biocompatibility studies. In -vitro enzymatic degradation was carried out in PBS media and cellular behaviour studies were analyzed using NIH3T3 cell lines. The results showed enhancement in the enzymatic degradation, proliferation, adhesion activity compared to that of pristine PVA films. In extension, nanocomposite films were subjected to hemocompatibility studies using human erythrocyte. The results revealed that nanocomposite films were biocompatible and hemocompatible. The fabricated films can be used in biomedical application.