[Fryns syndrome: report of the first case in the national literature]. / Síndrome de Fryns: informe del primer caso en la literatura nacional.

The Fryns' syndrome is characterized by multiple congenital deformities such as cranio-facial anomalies, diaphragmatic hernia, pulmonary hypoplasia, distal anomalies of the extremities and diverse cardiovascular, digestive, urogenital and central nervous system malformations. Heredity trait is recessive-autosomic with variable expression. Mortality is the rule. Diagnosis must be suggested by early polyhydramnios, premature delivery, familial tendency and perinatal mortality. In the present paper, a case with the most significant features and with other features not previously described is reported.

Ethynyl-estradiol (EE-2) retained in blood and endometrium during and after steroidal contraception.

Thirty-six women under norgestrel + EE-2 interrupted the medication after 2 to 36 months of regular use. A single venous blood and a single endometrial sample were simultaneously obtained from each subject on different days of the cycle to measure the synthetic estrogen content. Samples were collected during the last month of contraception and in the month after the medication. The EE-2 values (means +/- SE) during and after the "pill" were as follows: endometrial = 90 +/- 18 vs 234 +/- 5 ng/g wet tissue (P less than 0.001), and in blood = 90 +/- 18 vs 234 +/- 32 pg/ml (P less than 0.001). In a hysterectomized woman 30 micrograms of oral EE-2/d/20 d, yielded plasma EE-2 concentrations up to 979 pg/ml, descending to 30 pg/ml under no treatment. The results demonstrate that in intact women, exfoliation of the endometrium after one month of no steroidal ingestion, did not achieve the complete synthetic estrogen elimination from tissue, while blood levels of EE-2 increased during the same period of observation.

[Hormonal tissue concentration and oral contraceptives: the endometrium]. / Concentración hormonal tisular y los anticonceptivos orales: el endometrio.

PIP: The study investigates hormonal control of the menstrual cycle, adrenal function role, and endouterine menstrual disorders by an analysis of peripheral hormones and of their concentration at endometrial level. The authors also present a new radioimmunoassay method for determining hormone presence in plasma and in the endometrium. 59 ovulatory cycles were considered, and ovarian hormones were found to be 10-20 times higher in tissue than in plasma, but not in women under sequential or combined oral contraceptive treatment. The relation between endometrial estrogens and progesterone with plasma follicle stimulating hormone and luteinizing hormone levels is discussed, together with the significance of tissue hormone concentration.^ieng