MIND Diet Impact on Multiple Sclerosis Patients: Biochemical Changes after Nutritional Intervention.

There is substantial evidence supporting the neuroprotective effects of the MIND diet in neurodegenerative diseases like Parkinson's and Alzheimer's. Our aim was to evaluate the impact of a nutritional intervention (NI) with this diet on multiple sclerosis (MS) patients. The study was conducted in two stages. In the first stage, two groups were included: MS patients before the NI (group A) and healthy control subjects (group B). In this stage, groups (A) and (B) were compared (case-control study). In the second stage, group (A) was assessed after the NI, with comparisons made between baseline and final measurements (before-and-after study). In the case-control stage (baseline evaluation), we found significant differences in fatigue scores (p < 0.001), adherence to the MIND diet (p < 0.001), the serum levels of brain-derived neurotrophic factor (BDNF) (p < 0.001), and higher oxidative status in the MS group, with lower levels of reduced glutathione (p < 0.001), reduced/oxidised glutathione ratio (p < 0.001), and elevated levels of lipoperoxidation (p < 0.002) and 8-hydroxy-2'-deoxyguanosine (p < 0.025). The before-and-after intervention stage showed improvements in fatigue scores (p < 0.001) and physical quality-of-life scores (MSQOL-54) (p < 0.022), along with decreases in the serum levels of glial-derived neurotrophic factor (GDNF) (p < 0.041), lipoperoxidation (p < 0.046), and 8-hydroxy-2'-deoxyguanosine (p < 0.05). Consumption of the MIND diet is linked to clinical and biochemical improvement in MS patients.

Timing óptimo en la suplementación con creatina para la mejora del rendimiento deportivo / Optimal timing in creatine supplementation to improve sports performance

La creatina es un suplemento deportivo con una elevada evidencia científica sobre sus efectos en el rendimiento y con resultados emergentes en la salud, incluida la de deportistas vegetarianos y adultos mayores. El tipo de creatina y las dosis efectivas, han sido bien estudiadas presentando resultados consistentes. Sin embargo, no son muchos los estudios que han evaluado el momento de la ingesta en cuanto a su interacción con los efectos de la creatina. El objetivo de esta revisión, es analizar la diferente literatura científica existente sobre los protocolos de suplementación con creatina y su interacción con el momento de la ingesta, con el fin de evaluar si existe un efecto mayor de la dosis ergogénica considerada efectiva de creatina cuando esta es ingerida antes, después del entrenamiento o en otro momento del día. Los resultados de este trabajo presentaron diferentes tipos de protocolos y dosis en la suplementación con creatina, a pesar de ser diversos los protocolos mostrados en la literatura, el más efectivo constó de un consumo de 0,3 g/kg/d durante cinco días, seguido de un consumo de 0,03 g/kg/d consiguiendo de esta forma, una mayor reserva de PCr en el músculo esquelético. Los estudios mostraron mayores beneficios cuando la ingesta de creatina se realizó en los momentos cercanos al entreno debido al mayor flujo sanguíneo, apuntando los estudios a mejoras significativas en un consumo post-entreno, debido a que la creatina puede aumentar la formación de glucógeno en el músculo y aumentar la sensibilidad a la insulina

Creatine is a sports supplement with high scientific evidence on its effects on performance and with emerging health's results, including for vegetarian athletes and older adults. The creatine type and effective doses have been well studied, presenting consistent results. However, not many studies have evaluated the ingestion timing in terms of its interaction with the creatine effects. The aim of this review is to analyze the different existing scientific literature on creatine supplementation protocols and their interaction with the timing of ingestion, in order to assess whether there is a greater effect of the ergogenic dose of creatine considered effective when It is ingested before, post workout or at another time of the day. The results of this work presented different types of protocols and doses in creatine supplementation, despite being diverse the protocols shown in the literature, the most effective consisted of a consumption of 0.3 g/kg/d for five days, followed by a consumption of 0.03 g/kg/d, thus achieving a greater reserve of PCr in skeletal muscle. Studies showed greater benefits when creatine intake was carried out in the moments close to workout due to greater blood flow, the studies pointing to significant improvements in post-workout consumption, since creatine can increase the rate of glycogen uptake in muscle and increase insulin sensitivity

Morning versus Evening Intake of Creatine in Elite Female Handball Players.

A great deal of evidence has been gathered on the use of creatine as an ergogenic supplement. Recent studies show greater benefits when creatine ingestion is performed close in time to training, but few studies tackle the way that circadian rhythms could influence creatine consumption. The aim of this study was therefore to observe the influence circadian rhythms exert on sports performance after creatine supplementation. Our method involved randomly assigning fourteen women players of a handball team into two groups in a single-blind study: one that consumed the supplement in the morning and one that consumed it in the evening, with both groups following a specific training program. After twelve weeks, the participants exhibited a decreased fat percentage, increased body weight and body water, and improved performance, with these results being very similar in the two groups. It is therefore concluded that, although circadian rhythms may influence performance, these appear not to affect creatine supplementation, as creatine is stored intramuscularly and is available for those moments of high energy demand, regardless of the time of day.