Towards a personalized health care using a divisive hierarchical clustering approach for comorbidity and the prediction of conditioned group risks.

The objective was to assess risk of hospitalization and mortality of comorbidities using divisive hierarchical risk clustering to advice clinical interventions. Subjects and Methods: Data from the EHR of a general population, 3799885 adults, followed by 5 years. Model were performed using Spark and Scikit-learn and accuracy for the models was analyzed. Results: The number of models generated depends in part on the number of chronic diseases included (ex testing a sample of six diseases, a total number of 397 models for all-cause mortality and 431 models for hospitalization). The estimated models offered an ordered selection for the relevant clinical variables and their estimated risk as a group and for the individual patient in the group. Accuracy was assessed according to age, sex and the cardinality of the comorbid groups. A mobile version and dashboard were developed. Conclusion: The software developed stratified hospital admission and mortality risk in clusters of chronic diseases, and for a given patient, it could advise intensifying treatment or reallocating the patient risk.

SEQENS: An ensemble method for relevant gene identification in microarray data.

This paper describes an ensemble feature identification algorithm called SEQENS, and measures its capability to identify the relevant variables in a case-control study using a genetic expression microarray dataset. SEQENS uses Sequential Feature Search on multiple sample splitting to select variables showing stronger relation with the target, and a variable relevance ranking is finally produced. Although designed for feature identification, SEQENS could also serve as a basis for feature selection (classifier optimisation). Cliff, a ranking evaluation metric is also presented and used to assess the feature identification algorithms when a groundtruth of relevant variables is available. To test performance, three types of synthetic groundtruths emulating fictitious diseases are generated from ten randomly chosen variables following different target pattern distributions using the E-MTAB-3732 dataset. Several sample-to-dimensionality ratios ranging from 300 to 3,000 observations and 854 to 54,675 variables are explored. SEQENS is compared with other feature selection or identification state-of-the-art methods. On average, the proposed algorithm identifies better the relevant genes and exhibits a stronger stability. The algorithm is available to the community.

Decision support through risk cost estimation in 30-day hospital unplanned readmission.

Unplanned hospital readmissions mean a significant burden for health systems. Accurately estimating the patient's readmission risk could help to optimise the discharge decision-making process by smartly ordering patients based on a severity score, thus helping to improve the usage of clinical resources. A great number of heterogeneous factors can influence the readmission risk, which makes it highly difficult to be estimated by a human agent. However, this score could be achieved with the help of AI models, acting as aiding tools for decision support systems. In this paper, we propose a machine learning classification and risk stratification approach to assess the readmission problem and provide a decision support system based on estimated patient risk scores.