RESUMO
Donepezil is a cholinesterase inhibitor used for the treatment of patients with mild to moderately severe Alzheimer's disease (AD). The purpose of this study was to determine the effect of treatment with donepezil 5 mg qd on cognitive evoked potentials (EPs) of patients with AD. Although treatment with donepezil did not normalize EP latencies, treatment was associated with a significant decrease in the auditory P300 latency (mean latency pretreatment=401. 5 msec; posttreatment=392.7 msec.; P=0.04), and the visual P300 latency (mean latency pretreatment=605.7 msec; posttreatment=580.3 msec; P=0.04). Treatment with donepezil had no discernible effect on auditory or visual P300 EP amplitudes.
Assuntos
Doença de Alzheimer/tratamento farmacológico , Inibidores da Colinesterase/uso terapêutico , Potenciais Evocados P300/efeitos dos fármacos , Potenciais Evocados Auditivos/efeitos dos fármacos , Potenciais Evocados Visuais/efeitos dos fármacos , Indanos/uso terapêutico , Nootrópicos/uso terapêutico , Piperidinas/uso terapêutico , Idoso , Idoso de 80 Anos ou mais , Doença de Alzheimer/fisiopatologia , Donepezila , Feminino , Humanos , Masculino , Período Refratário Eletrofisiológico/efeitos dos fármacosRESUMO
Systematic assessment of cognition, mood, and function in geriatric psychiatry using simple psychological tests provides vital data for diagnosis, management, and treatment outcome. Use of such tests can assist in differentiating depressive pseudodementia and delerium from true dementia. This article presents a computer database program using serial administration of basic psychological tests which are readily obtainable and easily administered. Case histories describe how this testing format provides graphic data documenting treatment course and outcome. Research applications are suggested.
