RESUMO
This study analyzed the antidiabetic properties of an ethanol extract of the stem bark of Psidium guajava, an indigenous medicinal plant used to control diabetes in Indian System of Medicine. The anti-hyperglycaemic activity of this plant on blood glucose levels of normal, normal glucose loaded (OGTT) and alloxan-induced hyperglycaemic rats was evaluated. The results showed that ethanol stem bark extract exhibited statistically significant hypoglycaemic activity in alloxan-induced hyperglycaemic rats but was devoid of significant hypoglycaemic effect in normal and normal glucose loaded rats (OGTT).
Assuntos
Hipoglicemiantes/farmacologia , Psidium/química , Animais , Glicemia/metabolismo , Diabetes Mellitus Experimental/sangue , Diabetes Mellitus Experimental/tratamento farmacológico , Etanol , Feminino , Gliclazida/farmacologia , Teste de Tolerância a Glucose , Masculino , Casca de Planta/química , Extratos Vegetais/farmacologia , Ratos , Ratos Wistar , SolventesRESUMO
An aqueous and alcoholic extract of the roots of Aralia cachemirica (Araliaceae) were evaluated for hypoglycemic activity in normal fasted and glucose induced hyperglycemic rats. The aqueous and alcoholic extracts at a dose of 250 mg/kg showed statistically significant (p < 0.01) hypoglycemic activity in glucose loaded animals however no effect was observed in normal fasted rats.
Assuntos
Aralia/química , Glicemia/metabolismo , Hipoglicemiantes/química , Hipoglicemiantes/farmacologia , Animais , Etanol , Jejum/metabolismo , Feminino , Glucose/farmacologia , Masculino , Medicina Tradicional Tibetana , Extratos Vegetais/análise , Raízes de Plantas/química , Ratos , Ratos Wistar , Solventes , ÁguaRESUMO
An aqueous extract of Pterocarpus marsupium wood was screened for hypoglycemic activity on alloxan-induced diabetic rats. During both acute and sub-acute tests, the water extract, at an oral dose of 250 mg/kg, showed statistically significant hypoglycemic activity.
Assuntos
Diabetes Mellitus Experimental/tratamento farmacológico , Hipoglicemiantes/farmacologia , Fitoterapia , Pterocarpus/química , Animais , Glicemia/metabolismo , Feminino , Insulina/metabolismo , Masculino , Pâncreas/efeitos dos fármacos , Pâncreas/metabolismo , Extratos Vegetais/farmacologia , Ratos , Ratos Wistar , Solventes , ÁguaRESUMO
Effect of feeding orally the aqueous extract of beans of Cyamopsis tetragonoloba was investigated on fasting blood glucose levels in glucose loaded, normal and alloxan-induced diabetic rats and compared with gliclazide, a reference drug. The aqueous extract of beans at 250 mg/kg body wt significantly lowered blood glucose levels in alloxan-induced diabetic rats within 3 hr of administration. Continued administration of the extract at the same dose daily for 10 days produced statistically significant reduction in the blood glucose levels while marginal activity was seen in normal and glucose-loaded rats.
Assuntos
Cyamopsis/química , Diabetes Mellitus Experimental/tratamento farmacológico , Fitoterapia , Animais , Glicemia/metabolismo , Diabetes Mellitus Experimental/sangue , Feminino , Gliclazida/farmacologia , Hipoglicemiantes/farmacologia , Masculino , Extratos Vegetais/farmacologia , Ratos , Ratos WistarRESUMO
A water extract of Psidium guajava leaves was screened for hypoglycemic activity on alloxan-induced diabetic rats. In both acute and sub-acute tests, the water extract, at an oral dose of 250 mg/kg, showed statistically significant hypoglycemic activity.
Assuntos
Diabetes Mellitus Experimental/tratamento farmacológico , Fitoterapia , Psidium/química , Animais , Glicemia/metabolismo , Feminino , Índia , Masculino , Pâncreas/efeitos dos fármacos , Extratos Vegetais/uso terapêutico , Ratos , Ratos WistarRESUMO
A new oleanene-type triterpene, named betuloleanolic acid acetate and fernane-type triterpenes, namely betufernanediol A and betufernanediol B (isomers) have been isolated from the stem bark of Betula pendula. Their structures have been established as olean-12-en-3beta-ylacetate-29-oic acid, fern-22(29)-en-3beta,12beta-diol and fem-22(29)-en-3alpha,12beta-diol, respectively, on the basis of spectral data analysis and chemical reactions.
