Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Acta Trop ; 213: 105755, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33188747

RESUMO

PURPOSE: The aim of this study is to determine the prevalence of intestinal helminths and protozoa in patients with ulcerative colitis (UC) and to estimate the influence of the anti-parasitic therapy on the course of the disease. METHODS: The study was conducted at the Research Institute of Epidemiology, Microbiology and Infectious Diseases and Coloproctology Department of the Republic Clinical Hospital №1 of the Ministry of Health of the Republic of Uzbekistan. One hundred UC patients and 200 healthy individuals were examined by triple coproscopy. Additionally, 20, 25 and 22 UC patients with Blastocystis infection were treated with nitazoxanide (1.0 g/day), mesalazine (1.5-2 g/day) or a combination of nitazoxanide (1.0 g/day) and mesalazine (≥1.5-2 g/day) for 14 consecutive days, respectively. Parasitological, clinical and endoscopic examinations were conducted before therapy, immediately after and 6 and 12 weeks after therapy completion. RESULTS: The overall prevalence of helminths in UC patients and control individuals was not significantly different: 14±3.4% and 8.5±1.9%, respectively (OR: 1.7524; 95% CI: 0.8258 to 3.7186; P=0.1). Giardia lamblia was the most prevalent parasite in both groups, but the difference compared to the control was insignificant (OR: 0.4565; 95% CI: 0.2020 to 1.0318; P=0.05). A significantly higher prevalence of Blastocystis sp., Chilomastix mesnili and Iodamoeba butschlii in UC patients compared to control individuals was found (P<0.0005): 65.0%, 14.0% and 22.0%, respectively. During all follow-up periods, the clinical response and clinical remission were not statistically different between the groups (P>0.05). Mucosal healing immediately and 6 weeks after therapy with a combination of nitazoxanide with mesalazine was significantly better than with a monotherapy of nitazoxanide, respectively (P<0.05). UC patients treated with a combination of nitazoxanide with mesalazine showed better mucosal healing than in patients treated with a monotherapy of mesalazine (P>0.05). CONCLUSIONS: Diagnosis of Blastocystis sp. should be introduced in the complex examination of UC patients. Further clinical studies are necessary for assessment of the efficiency of anti-Blastocystis therapy in UC patients.


Assuntos
Anti-Inflamatórios não Esteroides/uso terapêutico , Antiparasitários/uso terapêutico , Infecções por Blastocystis/tratamento farmacológico , Blastocystis/isolamento & purificação , Colite Ulcerativa/tratamento farmacológico , Giardia lamblia/isolamento & purificação , Intestinos/parasitologia , Adulto , Animais , Anti-Inflamatórios não Esteroides/administração & dosagem , Antiparasitários/administração & dosagem , Blastocystis/efeitos dos fármacos , Infecções por Blastocystis/parasitologia , Colite Ulcerativa/parasitologia , Quimioterapia Combinada , Feminino , Giardia lamblia/efeitos dos fármacos , Humanos , Masculino , Mesalamina/administração & dosagem , Mesalamina/uso terapêutico , Pessoa de Meia-Idade , Nitrocompostos/administração & dosagem , Nitrocompostos/uso terapêutico , Prevalência , Tiazóis/administração & dosagem , Tiazóis/uso terapêutico , Resultado do Tratamento , Adulto Jovem
2.
Parasitol Res ; 117(12): 3715-3723, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30220046

RESUMO

The purpose of the present study was to determine the prevalence of intestinal helminths and protozoa in colorectal cancer (CRC) patients and to evaluate the possible association between the prevalence and CRC pathogenesis. A total of 200 CRC patients and 200 residents of Tashkent, who had no complaints related to the gastrointestinal tract, were examined by triple coproscopy using a concentration method and estimations of protozoan infection intensity. Of the CRC patients tested, 144 were classified as T1-4N0M0 (without metastases) and 56 were classified as T1-4N1-2M0-1 (with metastases). Parasitological examination was performed during CRC diagnosis before and after surgery and chemotherapy. A significantly higher prevalence of Blastocystis sp., Chilomastix mesnili, Jodamoeba butschlii, and Endolimax nana was found in CRC patients than in the control population (p < 0.0001), amounting to 80, 20, 22.5, and 11.5%, respectively. The high prevalence of Blastocystis sp., as well as the patterns of infection intensity, was stable at all stages of examination. The ratio of the number of CRC patients with and without Blastocystis sp. in the T1-4N0M0 and T1-4N1-2M0-1 groups amounted to 3.3 and 7.0, respectively. The ratios for C. mesnili, E. coli, J. butschlii, and E. nana in both groups were 0.2 and 0.2, 0.07 and 0.07, 0.3 and 0.16, and 0.18 and 0.01, respectively. The prevalence of helminths and Giardia lamblia in CRC patients and the control population was not significantly different. Taken together, these data indicate a possible role for Blastocystis sp. in CRC pathogenesis. Diagnosis, treatment, and further observation of patients with Blastocystis sp. are necessary at all stages of CRC, including during diagnosis and before and after surgery and chemotherapy.


Assuntos
Neoplasias Colorretais/patologia , Neoplasias Colorretais/parasitologia , Helmintíase/epidemiologia , Enteropatias Parasitárias/epidemiologia , Intestinos/parasitologia , Infecções por Protozoários/epidemiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Amoeba/isolamento & purificação , Animais , Blastocystis/isolamento & purificação , Endolimax/isolamento & purificação , Fezes/parasitologia , Feminino , Giardia lamblia/isolamento & purificação , Helmintíase/parasitologia , Helmintos/isolamento & purificação , Humanos , Enteropatias Parasitárias/parasitologia , Masculino , Pessoa de Meia-Idade , Prevalência , Infecções por Protozoários/parasitologia , Retortamonadídeos/isolamento & purificação , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...