[The apoB genotype and the efficacy of hypolipidemic therapy]. / Genotip apoB i éffektivnost' gipolipidemicheskoi terapii.

Several men were examined for association between restriction fragment length polymorphism (RELP) Xba I (exon 26) number of tandem repeats in 3'-hypervariable region of the apolipoprotein-B gene and serum levels of cholesterol and triglyceride. These two types of polymorphism were studied. An association of the Xba I site and alleles containing more repeats in the 3'-hypervariable region with higher cholesterol and triglyceride was observed. 32 patients with CHD aged 24-56 years were examined. All the patients are males with clinical picture of CHD (stable angina pectoris of II-III functional classes) and dyslipoproteinemia of II a, II b and IV types by D. S. Fredrickson. Xba-I polymorphism of apo-B gene was detected by DNA polymerase reaction method. The following Xba-I genotypes were distinguished: X1X1 (absence of Xba I site); X1X2 (heterozygosity on Xba I site) and X2X2 (homozygosity on Xba-I site). Lipantil (fenofibratte) was prescribed in a dose of 300 mg daily after meals (100 mg three times a day). Data obtained show that DNA polymorphism of apo-B gene not only influences plasma lipids concentration but also determines effectiveness of hypolipidemic therapy. Hypolipidemic effect of lipantil depends on Xba-I site presents in apo-B gene and is significantly expressed in homozygous patients with X1X1 genotype.

[Features of blood lipid spectrum in a schoolchildren's population in Kharkov]. / Osobennosti lipidnogo spektra krovi v populiatsii shkol'nikov Khar'kova.

The blood lipid and lipoprotein spectrum was biochemically studied in 580 pupils aged 12-16 years. The normal value ranges were found for total cholesterol (TC), triglycerides (T), high density lipoprotein (HDL) and low density lipoprotein in the Kharkov schoolchildren population. The upper limits of lipid lipoprotein levels enabled patients with hyperlipoproteinemias to be identified in the studied age groups. The Kharkov children were demonstrated to have high TC and T levels and relatively low HDL cholesterol, i. e. they had unfavourable characteristics as to atherogenesis. The findings suggest that the factors that influence the formation of atherogenic dyslipoproteinemias should be further studied and the preventive measures aimed at normalizing the lipid spectrum should be implemented.

[Ultraviolet irradiation of the blood in the treatment of patients with stable stenocardia]. / Ul'trafioletovoe obluchenie krovi v lechenii bol'nykh stabil'noi stenokardiei.

The authors established essential efficacy of monotherapy using ultraviolet irradiation of the blood in stable stenocardia of functional class II. It was also established that this method increased tolerance to physical load, correction of the hemodynamics and microcirculation.

[Comparative characteristics of the lipoprotein spectrum in hypercholesterolemia in 40- to 59-year-old men living in Moscow and Kharkov]. / Sravnitel'naia kharakteristika spektra lipoproteidov pri giperkholesterinemii u muzhchin 40--59 let, prozhivaiushchikh v Moskve i Khar'kove.

Total cholesterol, triglycerides and high- and low-density lipoprotein cholesterol were measured in a study of 40-59-years-old male populations in Moscow and Kharkov. Hypercholesterolemic individuals were identified, using standard criteria, in both cities. Although mean lipid parameters were similar in individuals with second-type hyperlipoproteinemia from Moscow and Kharkov, the pattern of hypercholesterolemia was different in terms of the lipoprotein spectrum. It is concluded that detailed differentiation of second-type hyperlipoproteinemia is essential for the identification of major mechanisms of the atherogenic potential of hypercholesterolemia in different populations.