[Distribution of immunogenetic markers of erythrocyte systems in ischemic heart disease]. / Osobennosti raspredeleniia immunogeneticheskikh markerov éritrotsitarnykh sistem pri ishemicheskoi bolezni serdtsa.

Distribution of 24 phenotypes of 6 red cell systems (ABO, Rh-Hr, MNSs, Duffy, Kell-Chellano, Kidd) has been studied for the first time in 275 coronary patients of Armenian nationality. Antigens ABO and MN were determined by hemagglutination, antigen Rho(D) by conglutination, antigens C, c, E, e, Fya, Fyb, Jka, Jkb, K and k by indirect Coombs reaction. Out of the 6 systems, only heterozygous phenotype Cc and homozygous phenotype Jk (a-b+) were positively associated with coronary heart disease. The carriers of the former had a risk of CHD 2.2-times that for patients carrying CC and Jk (a+b+), while the carriers of the latter had this risk increased 5-fold. Simultaneous identification of Kidd system phenotypes and Rh-Hr (Jkb (a-b+) and CC in the same patient may be considered as a genetic CHD marker in Armenian population. The above fact needs special attention in early preclinical diagnosis and prevention of CHD.

[Pathomorphologic changes in experimental siderosis]. / Patomorfologicheskie izmeneniia pri éksperimental'nom gipersideroze.

Experimental hypersiderosis was induced in rabbits by intravenous injection of iron-containing preparation Ferrum Leck. The resultant pronounced hemosiderosis was found in the liver, kidneys, heart, lungs and spleen. Dystrophic and necrotic processes arose in the liver, kidneys, heart. Accumulation of hemosiderin in the vascular walls led to their higher permeability, edema, wall thickness, proliferative changes, especially in the coronary vessels. Intravascular circulation impairment was evident from compression of microvessels by siderophages, red cells aggregation, formation of microthrombi.

[Autologous blood transfusion and the problem of "safe" blood]. / Autogemotransfuzii i problema "bezopasnoi" krovi.

A conception of "safe" blood has been proposed based on autohemotransfusions with the use of the methods of preparation of autologous blood, preoperative isovolemic hemodilution and intraoperative blood salvage. For the latter method special apparatus are needed, while the two former methods are easily performable without complex equipment and high expenses. The wide use of autohemotransfusions is considered as the most reasonable alternative under conditions of diminution of donor number, increased hazard of transmission of some infections through homologous blood transfusions.