[Methods for assessing aberrant and adaptive salience]. / Metody otsenki aberrantnoi i adaptivnoi salientnosti.

The term «salience¼ is most often used to describe «aberrant salience¼, which means assigning false significance to insignificant facts and details, that is inherent to patients with schizophrenia. Most often it is used in combination with «aberrant salience¼, which is understood as the assignment of false significance to insignificant facts and details. The term «adaptive salience¼ is less commonly used and means the «correct¼ assignment of the significance to important biological information. It is believed that in schizophrenia there is a decrease of adaptive salience in combination with an increase of aberrant salience. The concepts of aberrant and adaptive salience are a kind of link between the dopamine imbalance underlying the pathogenesis of schizophrenia and the diverse clinic of the disease. This article provides a review of the literature on methods for assessing, including quantitatively assessment, salience in schizophrenia. The comparison of these methods and their possible clinical and scientific application are provided.

Motor Decision-Making as a Common Denominator in Motor Pathology and a Possible Rehabilitation Target.

Despite the substantial progress in motor rehabilitation, patient involvement and motivation remain major challenges. They are typically addressed with communicational and environmental strategies, as well as with improved goal-setting procedures. Here we suggest a new research direction and framework involving Neuroeconomics principles to investigate the role of Motor Decision-Making (MDM) parameters in motivational component and motor performance in rehabilitation. We argue that investigating NE principles could bring new approaches aimed at increasing active patient engagement in the rehabilitation process by introducing more movement choice, and adapting existing goal-setting procedures. We discuss possible MDM implementation strategies and illustrate possible research directions using examples of stroke and psychiatric disorders.

[Neck pain and headache as the only manifestation of cervical artery dissection].

OBJECTIVE: To analyze clinical and neuroimaging data in patients with neck pain and headache as the only manifestation of the internal carotid artery (ICA) dissection (ICAD) and vertebral artery (VA) dissection (VAD). MATERIAL AND METHODS: One hundred and sixty-one patients (mean age - 37.4±4,99 years, 84 women, 52%) with cervical artery dissection (CAD) verified by magnetic resonance imaging (MRI) were enrolled. Neck pain and headache were the only CAD manifestation in 33 patients (mean age 37,3±7,4 yars, 28 women, 85%). RESULTS: The localization of the dissections in these patients was the following: one VA (15 patients), two VA (9), one ICA (7), two ICA (1), one ICA + two VA (1). The whole number of dissected arteries was 45: extracranial localization - 38, extra-intracranial - 6, intracranial - 1. Dissection led to stenosis of the arterial lumen in 41 arteries, to occlusion - in 2 and to dual lumen in 2 arteries. Small aneurism was found in 4 arteries. Combination of headache and the neck pain was observed in 26 out of 33 patients (79%), the only headache in 4 patients, the only neck pain in 3 patients. Along with this, 9 out of 24 VAD patients had the shoulder and/or arm pain. Headache in VAD patients was located more often in the occipital region (18 out of 24) that had never been observed in ICAD patients (p=0.0009). Fronto-temporal pain was observed more often in ICAD patients (5 out of 8 patients) than in VAD (2 out of 24 patients) (p=0.003). Neck pain in all VAD patients in comparison with 3 out ofI8 [CAD patients had posterior localization (p=0,007). Anterolateral neck pain was observed in 4 out ofI8 ICAD patients and in no patients with VAD (p=0.0009). The pain appearance was abrupt in all ICAD patients and most of the VAD patients. In 8 VAD patients the pain has been increasing during several hours. The pain intensity was severe in 19 patients, moderate in 12 and mild in 2. The characteristics of the pain were as following: constrictive/dull (26 patients), throbbing (1 patient) or combined (6 patients). Pain was increasing in a stepwise manner during the first days in 14 out of 24 VAD patients and in no one of ICAD patients (p=0.008). The mean pain duration period was 31 8 ± 15,7 days. Pain relief drugs were ineffective or had a short effect in 97% of patient. CONCLUSION: Isolated pain is more characteristic for women with VAD. Usually pain is presented as a combination of headache and neck pain. Pain localization, mode of appearance and the course are different in VAD and ICAD. The rarity of occlusion among patients with <> manifestation let to suggest that the intramural hematoma in this group of patients spreads to the adventitia that can reflect media weakness. Arterial wall changes underlying its weakness seem to be sex-hormone dependent taking into consideration the high predominace of women in cad manifested by isolated pain.

The mirror illusion induces high gamma oscillations in the absence of movement.

We tested whether mirror visual feedback (MVF) from a moving hand induced high gamma oscillation (HGO) response in the hemisphere contralateral to the mirror and ipsilateral to the self-paced movement. MEG was recorded in 14 subjects under three conditions: bilateral synchronous movements of both index fingers (BILATERAL), movements of the right hand index finger while observing the immobile left index finger (NOMIRROR), and movements of the right hand index finger while observing its mirror reflection (MIRROR). The right hemispheric spatiospectral regions of interests (ROIs) in the sensor space, sensitive to bilateral movements, were found by statistical comparison of the BILATERAL spectral responses to baseline. For these ROIs, the post-movement HGO responses were compared between the MIRROR and NOMIRROR conditions. We found that MVF from the moving hand, similarly to the real movements of the opposite hand, induced HGOs (55-85Hz) in the sensorimotor cortex. This MVF effect was frequency-specific and did not spread to oscillations in other frequency bands. This is the first study demonstrating movement-related HGO induced by MVF from the moving hand in the absence of proprioceptive feedback signaling. Our findings support the hypothesis that MVF can trigger the feedback-based control processes specifically associated with perception of one's own movements.

[Clinical characteristics of internal carotid and vertebral arteries dissection].

OBJECTIVE: To compare demographic, clinical, and imaging characteristics of patients with internal carotid artery dissection (ICAD) and vertebral artery dissection (VAD) in a Russian population. MATERIAL AND METHODS: One hundred fifty-two consecutive patients (74 males, 49%; mean age - 37.0±10.3 years) with cervical artery dissection (ICAD - 85 patients, 56%; VA - 62 patients, 41%; ICA+VA - 5 patients - 3%) verified by MRI/MRA were studied. Five patients with both ICAD and VAD were excluded from analysis. RESULTS: Patients with ICAD more often were men (63%, p<0.0001), while patients with VAD were women (69%, p<0.0001), age distribution was similar (37.4±11.2 and 36.2±9.4 years, p>0.05). The main precipitating events for VADs were neck movements, prolonged static turning of the head, physical exertion (57% vs 28% in ICAD, p=0.0009). Head trauma within the previous month was more often reported by ICAD patients than VAD patients (21% vs 7%, p=0.0295). Clinically ICADs more frequently manifested by ischemic stroke (IS) then VADs (82% vs 55% p=0.0004), but more rarely by isolated cervical pain/headache (10% vs 35%, p<0.0001). 85% patients with dissections had neck/headache preceding cerebral ischemia: isolated neck pain (27%, p=0.0001) or a combination of neck pain with headache (55%, p=0.0004) were characteristic of VADs while headache was typical for ICADs (71%, р=0.0001). According to MRI, bilateral ICADs were found more rarely than bilateral VADs (10% vs 31% p=0.0029). Arterial occlusion was more common for ICADs (61% vs 20%, p<0.0001), double lumen was found only in VAD patients (6%, p=0.0121), and aneurysms were revealed with similar frequency (ICAD 7%, VAD 5%). CONCLUSION: There were significant differences between patients with ICAD and VAD in terms of gender distribution, precipitating events, clinical and imaging features. Different embryonic origin of ICA and VA, their anatomical differences, and intramural hematoma location in relation to intima and adventitia may underlay these differences.

[Morphological signs of mitochondrial cytopathy in skeletal muscles and micro-vessel walls in a patient with cerebral artery dissection associated with MELAS syndrome].

Skin and muscles biopsy specimens of a patient harboring A3243G mutation in mitochondrial DNA, with dissection of internal carotid and vertebral arteries, associated with MELAS were studied using histochemical and electron-microscopy techniques. Ragged red fibers, regional variability of SDH histochemical reaction, two types of morphologically atypical mitochondria and their aggregation were found in muscle. There was correlation between SDH histochemical staining and number of mitochondria revealed by electron microscopy in muscle tissue. Similar mitochondrial abnormality, their distribution and cell lesions followed by extra-cellular matrix mineralization were found in the blood vessel walls. In line with generalization of cytopathy process caused by gene mutation it can be supposed that changes found in skin and muscle microvessels also exist in large cerebral vessels causing the vessel wall "weakness", predisposing them to dissection.

[Ultrastructural changes of skin arteries in patients with spontaneous cerebral artery dissection].

Spontaneous cerebral artery dissection is a common cause of ischemic stroke in young adults and children. Dissection is often related to arterial wall weakness the cause of which is unknown. An aim of the present paper was to carry out an electron microscopic study of skin arteries and arterioles in patients with ischemic stroke caused by cerebral artery dissection. Skin biopsy samples from 3 patients (2 men and one women, 15, 25 and 43 years of age, respectively) were studied. Electron microscopy revealed changes of endothelial, smooth muscle cells and fibroblasts in the skin microvessels. These changes included the decrease in the number of mitochondria and their alterations (vacuolization, destruction of the cristae, the presence of the needle-shaped crystals and crystal-like inclusions) and swelling of the endoplasmic reticulum. Some of these changes were characteristic of mitochondrial diseases. The changes in the extracellular matrix (thickening of the subendothelial layer and deposition of microcalcificats) were also detected. It is assumed that the mitochondrial cytopathy found in the skin microvessels may be also present in large cerebral arteries. This could underlie dysplastic changes in the cerebral artery wall and predispose to its dissection.

[The diagnostic of membranes' state after exposure of gamma-radiation of small doses].

There are the results of experimental research of the change of membranes' conditions under the action of gamma-radiation using the method of following membranes' electroporation of the accurate impulse of the electrical field for the analysis of defects after the action of gamma-radiation. As of the research material the suspension of erythrocytes was used. It was shown that the velocity of decreasing of the erythrocytes in the case of combined action of gamma-radiation and the impulse of the electrical field is more than the sum of such velocities in the case of the action of the factors separately. The method of the electroporation of the accurate impulse of the electircal field is obvious for the practicaland the analytical research of membranes' defects.

Solar proton events at the growth phase of the 22nd solar activity cycle.

Meteor satellite observations in March, August, September and October 1989 recorded intensive solar proton events which caused a disturbed radiation situation in the near-Earth space. The paper presents the results of analyzing flux and spectral characteristics of the events and their relation to heliogeophysical situation.

[Physiological and hygienic characteristics of working conditions of bus drivers in the Tadzhik SSR]. / Fiziologo-gigienicheskaia kharakteristika truda voditelei sovremennykh avtobusov v Tadzhikskoi SSR.

In warm seasons of the year, the major unfavourable factors in the labour conditions of bus-drivers engaged in local and transrepublican bus routes were heating microclimate, neuropsychic and physical overload, excessive noise levels. The unsatisfactory labour conditions resulted into strain and overstrain of the thermoregulatory function and cardio-vascular system, decreased working capacity and increased fatiguability, as well as in development of nonspecific pathology in the drivers. Improving of the labour conditions should include measures towards optimization of the microclimate and modernization of the cabin's design, rationalization of the labour regimen and improvement of services on the roads.

[Characteristics of solar cosmic radiation on the Meteor satellites]. / Issledovaniia kharakteristik solnechnogo ksomicheskogo izlucheniia na stupnikakh "Meteor".

The paper presents the results of examinations of solar cosmic rays recorded during 1969--1978 by Meteor satellites in the high latitude areas of the Earth magnetosphere. The purpose of the investigations is to develop methods for diagnosing and predicting the radiation environment in the near-Earth space. Morphological features of proton events, and their relationship with the characteristics of the source and the flare, the state of the interplanetary space and the magnetosphere are described.