Home-administered transcranial direct current stimulation is a feasible intervention for depression: an observational cohort study.

Transcranial direct current stimulation (tDCS) is an emerging treatment for major depression. We recruited participants with moderate-to-severe major depressive episodes for an observational clinical trial using Soterix Medical's tDCS telehealth platform as a standard of care. The acute intervention consisted of 28 sessions (5 sessions/week, 6 weeks) of the left anodal dorsolateral prefrontal cortex (DLPFC) tDCS (2.0 mA × 30 min) followed by a tapering phase of weekly sessions for 4 weeks (weeks 7-10). The n = 16 completing participants had a significant reduction in depressive symptoms by week 2 of treatment [Montgomery-Åsberg Depression Rating Scale (MADRS), Baseline: 28.00 ± 4.35 vs. Week 2: 17.12 ± 5.32, p < 0.001] with continual improvement across each biweekly timepoint. Acute intervention responder and remission rates were 75 and 63% and 88 and 81% following the taper period (week 10).

Measuring Contralateral Silent Period Induced by Single-Pulse Transcranial Magnetic Stimulation to Investigate M1 Corticospinal Inhibition.

Contralateral silent period (cSP) is a period of suppression in the background electrical muscle activity captured by electromyography (EMG) after a motor evoked potential (MEP). To obtain this, an MEP is elicited by a suprathreshold transcranial magnetic stimulation (TMS) pulse delivered to the primary motor cortex (M1) of the target muscle selected, while the participant provides a standardized voluntary target muscle contraction. The cSP is a result of inhibitory mechanisms that occur after the MEP; it provides a broad temporal assessment of spinal inhibition in its initial ~50 ms, and cortical inhibition after. Researchers have tried to better understand the neurobiological mechanism behind the cSP to validate it as a potential diagnostic, surrogate, and predictive biomarker for different neuropsychiatric diseases. Therefore, this article describes a method to measure M1 cSP of lower and upper limbs, including a selection of target muscle, electrode placement, coil positioning, method of measuring voluntary contraction stimulation, intensity setup, and data analysis to obtain a representative result. It has the educational objective of giving a visual guideline in performing a feasible, reliable, and reproducible cSP protocol for lower and upper limbs and discussing practical challenges of this technique.

Universal Transcranial Direct Current Stimulation (tDCS) Headset for targeting the bilateral Dorsolateral Prefrontal Cortex: Towards facilitating broader adoption.

Electrode position affects the brain current flow intensity and distribution induced by transcranial direct current stimulation (tDCS). The dorsolateral pre-frontal cortex (DLPFC) is a common target in neuropsychology and neuropsychiatry applications. A positioning scheme and subsequently a headgear has previously been developed to target the DLPFC automatically - devoid of any scalp ruler or neuronavigation method. This approach minimizes the time cost for pre-treatment measurements without compromising targeting accuracy and induced electric field focality. The goal of this study was to further develop this headgear to facilitate broader adoption while maintaining its core design elements intact. Briefly, we developed the headset to accommodate all adult head sizes (52-62 cm) rather than having multiple sizes, to have increased robustness, enhanced visual aesthetics, and have improved usability.We recruited 8 subjects and tested the accuracy of electrode placement on various head sizes. We also tested usability with the System Usability Scale (SUS) and asked the subjects to rate visual appeal. Our study demonstrated that the newly developed headset had greater usability and was more visually appealing than its predecessor without compromising targeting accuracy.Clinical Relevance- This study introduces a headset for routine tDCS administration targeting bilateral DLPFC. The headset is highly usable, robust, and is expected to facilitate home and high-volume use.

Galvanic Vestibular Stimulation Headset balancing robust and simple administration with subject comfort: A Usability Analysis.

The vestibular system is responsible for spatial orientation and stability. It can be stimulated with a weak electric current, a mechanism known as Galvanic Vestibular Stimulation (GVS). Typical GVS administration involves holding down electrodes on the mastoids either with a strap (or bandage) wrapped around the head or by positioning a self-adhesive electrode at the mastoid location. While the latter approach is simple to administer, it is limited to exposed skin application as hair impedes adhesion. The reduced access area limits total current delivery allowable due to increased skin sensation. Accordingly the former approach is more typically employed but leads to inconsistent and inaccurate electrode placement. As current flow pattern is directly influenced by electrode position, this results in inconsistent stimulation and replicability issues. The primary goal of this study was to test usability and comfort while developing a GVS-specific headset named "Mastoid Adjustable Robust Stimulation (MARS)" compared to a conventional elastic strap. We recruited 10 subjects, 5 operators and 5 wearers, and tested usability using the System Usability Scale (SUS) as well as comfort levels over a typical 20 minute stimulation session. Additional questions were answered by the operators and wearers on visual appeal, interference, slippage, and electrode placement. The results of this testing guided the development of a final version meeting our requirements of robustness, simple to administer, and subject comfort.Clinical Relevance-This study introduces a headset for routine Bilateral-Bipolar GVS administration that is highly usable and ensures both flexible and consistent electrode application over typical approaches.

Optimized Electrode Placements for Non-invasive Electrical Stimulation of the Olfactory Bulb and Olfactory Mucosa.

The olfactory system is known to be dysfunctional in the early stages of Parkinson's disease (PD) and Alzheimer's disease (AD). It is also shown that intact olfactory function can be a key role player for regaining consciousness after brain injuries. Modulation of the olfactory regions has been attempted successfully with electrical stimulation over the years, either directly (transethmoidally, intraoperatively, internasally, etc.) or indirectly through the vagus nerve. We sought to develop a means of delivering optimized electrical stimulation to the olfactory region in a non-invasive fashion and in a way that is simpler, easier, and less cumbersome. The ultimate goal was to develop a system that would allow easier testing in future clinical trials presenting an opportunity to fully develop this potential treatment option. We devised six potential electrode placements leveraging commonly accepted facts of electrical stimulation, easier access through relatively higher conductive pathways into the brain, and practicality. Using an ultra-high-resolution finite element model, we screened each one of these montages for their ability to target the olfactory regions primarily and thereafter for select sub-cortical regions implicated in the pathogenesis of PD and AD. Modeling results indicate that some placements do result in inducing meaningful electric field magnitudes in the regions of interest. A practical headgear concept is proposed to realize the most ideal configuration. Our results pave the way for developing the first non-invasive electrical stimulation wearable system for targeting the olfactory regions which can help to alleviate the symptoms or suppress the progression of these neurological disorders.