You can't play with us: First-person ostracism affects infants' behavioral reactivity.

Ostracism negatively affects fundamental psychological needs, induces physiological and behavioral changes, and modulates the processing of social information in adults. Yet little is known about children and preverbal infants' responses to first-person experiences of ostracism. The current study aimed to explore the efficacy of a triadic ball-tossing game in manipulating social inclusion and ostracism with 13-month-old infants (N = 84; 44% males; mostly White; tested from 2019 to 2022) by developing an observational coding system. Infants' behaviors were recorded while participating in a ball-tossing game where they were either included or ostracized from the game. Ostracized, but not included, infants showed an increase in negative emotionality and involvement behaviors, thus suggesting that behavioral responses to being ostracized emerge early in life.

The biological underpinnings of perinatal depressive symptoms: A multi-systems approach.

BACKGROUND: Well-established evidence exists of an association between depressive symptoms and alterations in the stress and inflammatory response systems; however, the picture is far less coherent during the perinatal period. This study combines the assessment of multiple stress and inflammatory biomarkers in late pregnancy and after delivery in order to investigate cross-sectional and prospective associations with perinatal depressive symptoms. METHODS: One-hundred-ten healthy women were assessed in late pregnancy (mean gestational age=34.76; SD=1.12) and 89 were re-evaluated after delivery (mean hours after delivery=52.36; SD=19.70) for depressive and anxiety symptoms through the Edinburgh Postnatal Depression Scale and the State-Trait Anxiety Inventory. Serum Interleukin-6 (IL-6), C-Reactive Protein (CRP) and diurnal salivary cortisol levels were measured on both occasions, while diurnal salivary alpha amylase (sAA) levels were assessed in late pregnancy. RESULTS: Using Hierarchical Linear Models, higher depressive symptoms were found to be associated with higher IL-6 levels, lower morning cortisol levels and a flatter cortisol diurnal slope during pregnancy, while adjusting for potential confounders. No significant associations were found after delivery or with change in biomarker levels from pre- to post-partum. Furthermore, preliminary evidence of a positive association between inflammation and stress markers in women with higher antenatal depressive symptoms was found. LIMITATIONS: The sample was relatively small and highly selected, thus limiting generalizability of the findings. CONCLUSIONS: Results emphasize the need for an integrated multi-systems approach to the understanding of the biological underpinnings of perinatal depression and suggest that the stress-immune interactions represent a promising avenue for future endeavor.

Beyond the HPA-axis: Exploring maternal prenatal influences on birth outcomes and stress reactivity.

Accumulating evidence suggests that antenatal maternal stress is associated with altered behavioral and physiological outcomes in the offspring, however, whether this association is causal and the underlying biological mechanisms remain largely unknown. While the most studied mediator of maternal stress influences on the fetus has generally been cortisol, alternative novel markers of stress or inflammation warrant further consideration. The current investigation explored the influence of variations in self-reported symptoms of distress, stress hormones and inflammatory markers on infant birth outcomes and early stress regulation. The sample consisted of 104 pregnant women (mean gestational age = 34.76; SD = 1.12) and their healthy newborns. Maternal self-reported symptoms of depression and anxiety were evaluated through the Edinburgh Postnatal Depression Scale and the State-Trait Anxiety Inventory and levels of serum Interleukine-6 (IL-6), C-Reactive Protein (CRP), salivary cortisol and alpha amylase (sAA) were measured in late pregnancy. Newborns' cortisol and behavioral response to the heel-stick was assessed 48-72 hours after birth. The associations between maternal stress measures and infant birth outcomes and stress reactivity, adjusted for potential confounders, were examined through hierarchical linear regressions and hierarchical linear models. Higher maternal IL-6 levels were associated with smaller head circumference at birth, while diurnal sAA levels were positively associated with birthweight. Maternal diurnal cortisol was related to newborn's stress reactivity: a flatter infant cortisol response to the heel-stick was associated with greater maternal cortisol increases after awakening during pregnancy, while greater infant behavioural reactivity was related to a flatter maternal diurnal cortisol profile. The observational nature of these data does not allow for causal inferences but the current findings illustrate that antenatal factors related to alterations in maternal stress and immune response systems are associated with fetal growth and neonatal stress reactivity. This may have implications for later health and psychological outcomes.

[Quality of life of geriatric patients after surgery. VII. Lung tumors]. / Qualità di vita del paziente geriatrico dopo intervento chirurgico. Nota VII: Tumori del polmone.

After reviewing the literature on this subject, the authors examine the results of a five-year follow-up in all patients undergoing lung cancer surgery. The results obtained showed that old-age patients (third age) are more numerous than geriatric (fourth age) patients, and males are more frequently affected than females. The most frequent localisation in the series examined was the upper right lobe and the majority of these patients underwent lobectomy, the form of surgery that produced the best results (30.3% alive and well with a Karnofski index as high as 90 in some cases). The authors conclude that when the patient's conditions allow, surgery is advisable in lung cancer in an attempt to improve the patient's quality of life.