RESUMO
Corneal ulcers to the depth of the anterior third of the stroma were created surgically in both eyes of 10 ponies. One eye in each pony was treated topically with chloramphenicol and 1% atropine ophthalmic ointments 3 times per day; the contralateral eye was not treated topically. All ponies were given phenylbutazone orally for relief of ocular pain. Fluorescein-stained ulcers were measured once a day. The median healing time of the treated eyes (11 days) and the median healing time of the nontreated eyes (13.5 days) were found not to be significantly different. Clinically, however, more severe complications arose in the nontreated eyes.
Assuntos
Atropina/uso terapêutico , Cloranfenicol/uso terapêutico , Úlcera da Córnea/veterinária , Doenças dos Cavalos/tratamento farmacológico , Animais , Úlcera da Córnea/tratamento farmacológico , Feminino , Cavalos , Masculino , Pomadas , Fenilbutazona/uso terapêutico , Fatores de TempoRESUMO
The effect on cell-mediated immunity of two hypoxic cell radiosensitizers, metronidazole and misonidazole, was examined. Immunocompetence was assayed by measuring delayed hypersensitivity reactions in mice sensitized on the abdomen with 2,4-dinitro-1-fluorobenzene (DNFB) and subsequently challenged on the ears with DNFB. Single and fractionated treatments with misonidazole or metronidazole were found to suppress delayed hypersensitivity reactions to DNFB. This finding is in agreement with other data in the literature which show that many imidazoles, including nitroimidazoles, inhibit aspects of the cell-mediated immune response in animals and man. The potential immunosuppressive effects of nitroheterocyclic radiosensitizers should be considered when these agents are evaluated in the laboratory or used in the clinic.
