RESUMO
The paper presents the studies of some new complexes of norfloxacin (Nf) and ofloxacin (Of) with Cd(II) and Hg(II). The synthesis, purification and the elemental chemical analysis of the Nf and Of compounds have been performed in order to obtain the chemical formulas. These formulas are confirmed by molecular mass determinations. IR, UV-VIS reflectance spectra were recorded, as well as electric conductometric measurements. These techniques confirm that the obtained compounds are electrolytes and give some hints about their molecular structures. The antimicrobial activity was tested using plates containing Muller-Hinton cultures as well as Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. All compounds and their Nf and Of ligands exert an obvious antimicrobial activity.
Assuntos
Anti-Infecciosos/química , Anti-Infecciosos/farmacologia , Norfloxacino/análogos & derivados , Ofloxacino/análogos & derivados , Cádmio/farmacologia , Escherichia coli/efeitos dos fármacos , Mercúrio/farmacologia , Norfloxacino/química , Norfloxacino/farmacologia , Ofloxacino/química , Ofloxacino/farmacologia , Compostos Organometálicos/química , Compostos Organometálicos/farmacologia , Pseudomonas aeruginosa/efeitos dos fármacos , Staphylococcus aureus/efeitos dos fármacosRESUMO
Synthesis and chemical and physical characterization of four new complex compounds of thiobenzpyrolidide [1-(pyrolidine)-thiobenzoyl] with Pd(II), Pt(II), Cu(I) and Hg(II) are presented. The purposed chemical structure for these complexes is suggested by the elemental chemical analysis, molecular mass measurements, electric conductivities as well as by UV-VIS and IR spectra. The obtained compounds may in principle be used as enzyme inhibitors having a pronounced insecticidal action.
Assuntos
Cobre/química , Inseticidas/síntese química , Mercúrio/química , Compostos Organometálicos/síntese química , Paládio/química , Platina/química , Tioamidas/química , Cátions Bivalentes , Inseticidas/análise , Inseticidas/química , Estrutura Molecular , Compostos Organometálicos/análise , Compostos Organometálicos/química , EspectrofotometriaRESUMO
Synthesis and physical-chemistry characterization of five new genuine complex compounds of 1-Benzylidine-2-phenazinoylhydrazine with Pd(II), Pt(II), Ni(II), Hg(II) and Cu(I) are presented. The chemical structure for these complexes is suggested by the elemental chemical analysis, molecular mass measurements, electric conductivities as well as by IR and UV-VIS spectra. The metal:ligand molar ratio is found 1:1, the obtained complexes belonging to the square planar geometry D4h.
