RESUMO
Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are intra-ovarian signalling peptides that are important in follicle development and oocyte maturation. In the ovary, neurotrophin expression is regulated by gonadotrophins. Therefore, this study postulates that aetiology of infertility will affect follicular-fluid BDNF and NGF concentrations. Follicular fluid from the first follicle aspirated from 190 infertile women attending a university-affiliated fertility programme (McMaster University and ONE Fertility, Burlington, Ontario) was collected between February 2004 and November 2010. The relationship between follicular-fluid BDNF and NGF concentration and age, day-3 FSH and peak serum oestradiol concentrations and antral follicle count was determined. Participants were aged between 24 and 44 years (mean±SEM, 35.2±0.3years) of age. The median concentrations of BDNF and NGF in the follicular fluid was 19.4pg/ml and 344.6ng/ml, respectively. The concentrations of BDNF and NGF were significantly related (P=0.028) but only the BDNF concentration was significantly higher (P<0.05) in women with unexplained infertility compared with other causes of infertility. It is concluded that, apart from unexplained infertility, the underlying cause of infertility did not affect ovarian output of BDNF and NGF in response to ovulation induction.
Assuntos
Líquido Folicular/química , Infertilidade Feminina/metabolismo , Adulto , Fator Neurotrófico Derivado do Encéfalo/metabolismo , Estradiol/sangue , Feminino , Hormônio Foliculoestimulante/metabolismo , Líquido Folicular/metabolismo , Humanos , Infertilidade Feminina/etiologia , Fator de Crescimento Neural/metabolismo , Indução da Ovulação , Estudos ProspectivosAssuntos
Pé Diabético/terapia , Oxigenoterapia Hiperbárica , Amputação Cirúrgica , Análise Custo-Benefício , Pé Diabético/fisiopatologia , Medicina Baseada em Evidências , Humanos , Oxigenoterapia Hiperbárica/economia , Oxigenoterapia Hiperbárica/métodos , Oxigenoterapia Hiperbárica/normas , Resultado do Tratamento , CicatrizaçãoAssuntos
Neovascularização Fisiológica/fisiologia , Cicatrização/fisiologia , Angiostatinas , Plaquetas/fisiologia , Colágeno/fisiologia , Endopeptidases/fisiologia , Endostatinas , Fatores de Crescimento Endotelial/fisiologia , Matriz Extracelular/fisiologia , Fatores de Crescimento de Fibroblastos/fisiologia , Tecido de Granulação/fisiologia , Substâncias de Crescimento/fisiologia , Fator de Crescimento de Hepatócito/fisiologia , Humanos , Ácido Hialurônico/fisiologia , Integrinas/fisiologia , Peptídeos e Proteínas de Sinalização Intercelular/fisiologia , Interleucina-4/fisiologia , Linfocinas/fisiologia , Fragmentos de Peptídeos/fisiologia , Plasminogênio/fisiologia , Fator de Crescimento Derivado de Plaquetas/fisiologia , Fator de Crescimento Transformador beta/fisiologia , Fator de Necrose Tumoral alfa/fisiologia , Fator A de Crescimento do Endotélio Vascular , Fatores de Crescimento do Endotélio VascularRESUMO
Radiation therapy for the treatment of maxillofacial tumours can lead to delayed complications. One of the most severe complications is osteoradionecrosis (ORN), which can cause orocutaneous fistulae, exposed mandible and considerable pain. The condition can occur years after radiotherapy and requires aggressive prevention and treatment. Hyperbaric oxygen therapy has been found beneficial for patients with maxillofacial ORN, leading to pain relief, fistula closure and bone coverage.
Assuntos
Neoplasias Maxilares/radioterapia , Humanos , Oxigenoterapia Hiperbárica , Osteorradionecrose/terapiaAssuntos
Fasciite Necrosante , Adolescente , Adulto , Bandagens , Fasciite Necrosante/diagnóstico , Fasciite Necrosante/etiologia , Fasciite Necrosante/terapia , Evolução Fatal , Feminino , Gangrena de Fournier/complicações , Humanos , Masculino , Pessoa de Meia-Idade , Infecções Estreptocócicas/complicaçõesRESUMO
The impact of an X-autosome translocation t(Xp+; 14q-), on ovulation, fertilization and embryo survival in carrier sows, was examined and compared with these parameters of normal sows. Corpora lutea counts during week-2 and week-4 of gestation were similar in normal and carrier sows (14.4 +/- 1.36 and 15.5 +/- 2.18) although embryo recovery (11.0 +/- 1.87 and 6.0 +/- 1.47) was lower than that from normal sows (12.8 +/- 1.46 and 11.5 +/- 0.87), at these stages. Among the embryos karyotyped from the week-2 embryos of carrier sows, 42% were normal, 26.4% were carriers and 31.6% were of unbalanced chromosome make-up, and of the week-4 embryos of carriers, 33.3% were normal, 57.1% were carriers and 9.1% were chromosomally unbalanced females. The preponderance of females among the unbalanced embryos recovered at week-2 of gestation (11_ and 1_) and the total absence of males among those recovered at week-4, suggest that oocytes with unbalanced chromosome constitution are eliminated before week-2 of gestation if they are fertilized by Y bearing sperm, and that the unbalanced oocytes fertilized by X bearing sperm survive up to the peri-attachment stage even though all chromosomally unbalanced embryos are eliminated before term regardless of their sex.
Assuntos
Perda do Embrião/genética , Fertilização/genética , Ovulação/genética , Suínos/genética , Translocação Genética , Cromossomo X/genética , Animais , Feminino , Triagem de Portadores Genéticos , Meiose/genética , Suínos/fisiologiaRESUMO
A survey was conducted on the chromosome makeup and breeding data of pigs housed at the Arkell Research Station, University of Guelph, to determine the reproductive impact of a reciprocal translocation previously identified as t(Xp+;14q-). Blood samples were cultured and chromosome spreads were examined to identify carriers in the herd. Gonadal features of carrier boars and piglets and their age-matched normal counterparts were studied, and the reproductive history of carrier sows, including the number of breedings required for conception, mean litter size, prevalence of still births and malformations, and sex distribution among the piglets, was compared with that of normal (noncarrier) sows. Our observations on testicular histology confirmed that X-autosome translocation-carrier boars are sterile, and the analysis of reproductive data showed that the most striking effects of t(Xp+;14q-) on sows are the 50% increase in the number of breedings required for conception and the over 25% reduction in litter size compared with that of normal sows. The reproductive impact of this and similar translocations on the herd and on the swine industry in general is discussed.
Assuntos
Infertilidade Masculina/veterinária , Reprodução/fisiologia , Aberrações dos Cromossomos Sexuais/veterinária , Doenças dos Suínos/genética , Translocação Genética , Cromossomo X/genética , Animais , Feminino , Triagem de Portadores Genéticos , Infertilidade Masculina/genética , Masculino , História Reprodutiva , Aberrações dos Cromossomos Sexuais/genética , Suínos , Testículo/patologiaRESUMO
NOISE AND WOUND HEALING FOUR-LAYER BANDAGE STUDY MANAGEMENT SYSTEMS NECROTISING FASCIITIS DISFIGURING INJURIES.
RESUMO
The care of a patient with clostridial myonecrosis and necrotising fasciitis at a specialist centre for hyperbaric oxygen is described.
RESUMO
AIDS AND ACCOUNTABILITY COMPARING DRESSINGS FOR DIABETIC FOOT ULCERS SHEEPSKINS AND PRESSURE SORE PREVENTION CENTRAL VENOUS LINES HYDROGEL AND NAPPY RASH.