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Int Arch Allergy Immunol ; 159(2): 179-82, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22678151

RESUMO

BACKGROUND: Peanut allergy is the leading cause of food-related anaphylaxis, and accidental exposures are common. Oral immunotherapy (OIT) has been posited as a potential treatment. METHODS: Patients aged 3-65 years with peanut-specific IgE ≥7 kU/l and/or a positive skin prick test with a history of an allergic reaction to peanut were recruited to undergo an OIT protocol. All adverse reactions were recorded by research staff or patients in real time. RESULTS: Twenty-four patients received 6,662 doses. Symptoms were mostly mild (84%), and only 3 severe gastrointestinal reactions required the administration of epinephrine. Abdominal pain was the most common reaction, followed by oropharyngeal and lip pruritus. Respiratory symptoms were rare. CONCLUSIONS: In this trial of OIT in adults and children, most reactions were mild.


Assuntos
Dessensibilização Imunológica/efeitos adversos , Hipersensibilidade a Amendoim/terapia , Administração Oral , Adolescente , Adulto , Alérgenos/administração & dosagem , Alérgenos/efeitos adversos , Arachis/efeitos adversos , Arachis/imunologia , Criança , Pré-Escolar , Dessensibilização Imunológica/métodos , Feminino , Humanos , Imunoglobulina E/sangue , Masculino , Pessoa de Meia-Idade , Hipersensibilidade a Amendoim/diagnóstico , Hipersensibilidade a Amendoim/imunologia , Proteínas de Vegetais Comestíveis/administração & dosagem , Proteínas de Vegetais Comestíveis/efeitos adversos , Segurança , Testes Cutâneos
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