RESUMO
We report two cases of insulinoma with increased serum proinsulin levels and with normal insulin levels.Clinically, the two patients show typical symptoms of insulinoma, but serum insulin levels are normal. Only high levels of serum proinsulin allow us to retain the diagnosis of insulinoma. The new insulin assays using monoclonal antibodies are very specific for insulin and though can not detect isolated high proinsulin levels. So proinsulin assay is useful when diagnosing insulinoma.
Assuntos
Insulinoma/sangue , Insulinoma/diagnóstico , Neoplasias Pancreáticas/sangue , Neoplasias Pancreáticas/diagnóstico , Proinsulina/sangue , Adulto , Anticorpos Monoclonais , Especificidade de Anticorpos , Feminino , Humanos , Insulinoma/cirurgia , Masculino , Pessoa de Meia-Idade , Neoplasias Pancreáticas/cirurgiaAssuntos
Hidrocortisona/sangue , Insuficiência Adrenal/sangue , Insuficiência Adrenal/induzido quimicamente , Agonistas Adrenérgicos beta/administração & dosagem , Agonistas Adrenérgicos beta/uso terapêutico , Antiasmáticos/uso terapêutico , Anti-Inflamatórios/efeitos adversos , Anti-Inflamatórios/uso terapêutico , Asma/tratamento farmacológico , Betametasona/uso terapêutico , Broncodilatadores/administração & dosagem , Broncodilatadores/uso terapêutico , Feminino , Glucocorticoides/efeitos adversos , Glucocorticoides/uso terapêutico , Humanos , Metilprednisolona/efeitos adversos , Metilprednisolona/uso terapêutico , Pessoa de Meia-IdadeRESUMO
BACKGROUND: Recently, hepatitis C virus (HCV) have been recognised as being one of the most important cause of non-A, non-B hepatitis. Although parenteral transmission of HCV is wellknown, the risk of sexual transmission is still under debate. OBJECTIVE: This study was conducted to assess the HCV infection markers in sexually transmitted disease (STD) patients from an endemic area for hepatitis B virus (HBV) infection. Additionally, we studied the prevalence of HBV infection markers in these patients. PATIENTS AND METHODS: The sera of 121 patients with STD from Cluj-Napoca have been tested for antibodies to HCV (anti-HCV), Hbs antigen (Hbs Ag), antibodies to Hbc antigen (anti-HBc), by automated ELISA. RESULTS: Anti-HCV were detected in 26/121 (21.5%) patients: 73/121 (60.3%) patients presented HBV infection markers HBV infection markers (HbsAg and or anti-HBc) have been observed in 22/26 (84.6%) HCV infected patients. CONCLUSIONS: Prevalence of HCV infection markers in STD patients from Cluj is high (21.5%). HBV infection markers have been detected in 60.3% of patients. In STD patients form Cluj HCV infection markers have been correlated to HBV infection markers.
Assuntos
Hepatite B/imunologia , Hepatite C/imunologia , Infecções Sexualmente Transmissíveis/imunologia , População Urbana , Adulto , Biomarcadores/sangue , Distribuição de Qui-Quadrado , Feminino , Anticorpos Anti-Hepatite/sangue , Antígenos de Hepatite/sangue , Hepatite B/epidemiologia , Hepatite C/epidemiologia , Humanos , Masculino , Prevalência , Romênia/epidemiologia , Estudos Soroepidemiológicos , Infecções Sexualmente Transmissíveis/epidemiologia , População Urbana/estatística & dados numéricosRESUMO
OBJECTIVE: We studied the prevalence of viral hepatitis B, C and D markers in chronic hepatopathies from Cluj. MATERIAL AND METHODS: Sera of 297 patients with chronic hepatopathies (236 adults and 61 children) have been tested for viral hepatitis markers: HBsAg, anti-HBc, anti-HBs, HBeAg, anti-HBe, anti-HDV, anti-HCV, by automated ELISA. RESULTS: HBV infection markers in 32% (adults) and 4.9% (children), and HDV infection markers in 11.8% (adults) and 26.3% (children). Double (HBV and HCV) and triple infection (HBV, HDV and HCV) were observed in 28.4% (adults), 4.9% (children), and 3.4% (adults), 0% (children), respectively. CONCLUSIONS: Hepatitis virus infection markers, especially HBV and HCV play an important role in the determinism of chronic hepatopathies from Cluj area, both in children and adults.