RESUMO
An observation of oncocytic carcinoid of the lung is described. The diagnosis was established by electron microscopic examinations which revealed a large number of mitochondria in cell elements of the tumor. Morphological differential diagnosis of this kind of carcinoid, particularly in the pre-operative period, is difficult because signs of oncocytic neoplasias such as large cell size, oxyphilia, and cytoplasmic granularity may be found in metastases of some kinds of cancers as well as in oncocytic adenoma of the lung.
Assuntos
Adenoma/patologia , Tumor Carcinoide/patologia , Neoplasias Pulmonares/patologia , Adenoma/ultraestrutura , Adulto , Tumor Carcinoide/ultraestrutura , Humanos , Neoplasias Pulmonares/ultraestrutura , Masculino , Microscopia EletrônicaRESUMO
Epidermoid thymoma was referred to thymal malignancies after an evaluation of the data on its clinical course and microscopic structure. This tumor may be diagnosed preoperatively on the basis of an analysis of clinico-roentgeno-endoscopic data and findings of a cytological, histological and electron-microscopic examinations.
Assuntos
Carcinoma de Células Escamosas/patologia , Timoma/patologia , Neoplasias do Timo/patologia , Adulto , Feminino , Humanos , MasculinoRESUMO
Cytological, histological, and ultrastructural examinations of 6 cases of adenoid cystic carcinoma of the bronchi were carried out. Cytological studies demonstrated cells of two types: smaller, rounded or slightly elongated cells with hyperchromic nuclei and scarce basophilic cytoplasm, and larger cells with clear nuclei and basophilic, slightly vacuolated cytoplasm. The cells are located among oxyphilic homogeneous substance. Histologically the tumour has a typical cribrose appearance owing to glandular-like and cyst-like cavities among alveolar cell aggregates embedded into intensely developed but poor in cells and somewhat hyalinized stroma. The invasive growth of the tumour with its extension into the depth of the lung on interalveolar septae, perivascular and peribronchial spaces with outgrowth of the capsule was manifest in all cases. Electron microscopic studies showed the tumour elements to be lowly differentiated epithelial cells. No ultrastructural signs of myothelium or secretory mucous activity was found. The results of these studies indicate that this tumour should be designated as adenoid cystic carcinoma but not adenoma of cylindromatous type.
