[Synthesis of anomeric 5-trimethylgermyl-2'-deoxyuridines and study of their antiviral and cytotoxic properties]. / Sintez anomernykh 5-trimetilgermil-2'-dezoksiuridinov i izuchenie ikh protivovirusnykh i tsitotoksicheskikh svoistv.

Glycosylation of silylated 5-trimethylgermyluracil with 2-deoxy-3,5-di-O-p-toluyl-alpha-D-ribofuranosylchloride in dichloroethane in the presence of SnCl4 and subsequent deacylation led to anomeric 5-trimethylgermyl-2'-deoxyuridines. The alpha-nucleoside inhibits HSV-1 replication in vitro, blocks 2'-deoxyuridine incorporation into DNA of hepatoma 22A cells and incorporation of thymidine into DNA of cancer ovarian cells as well. Treatment with 125 mg/kg X 5 days of alpha-nucleoside fails to increase the life-span of mice with leukemia P388.