RESUMO
We have evaluated the performance of the Bayer Immuno 1 serum HER-2/neu assay. The precision is excellent and varied between 1.7% and 2.1% at values of HER-2/neu ranging from 16.8 ng/mL to 108.6 ng/mL. In normal women who were followed on a monthly basis the average deviation was 6%. The concentration (mean +/- SD) in normal women was 8.7 +/- 3.2 ng/mL. There was no difference between pre and postmenopausal women. The normal/abnormal cutoff was defined as greater than 15 ng/mL. In normal women and those with benign disease the specificity varied between 95% and 100%. In women with breast cancer the sensitivity was 1.7% in stage I disease, 3.0% in stage II, 16.7 in stage III and 35.5% in stage IV. There were 56 elevations (14.7%) in the total group of 285 women with breast cancer. There was an excellent correlation with a microtitre plate method (r=0.9944). Longitudinal studies showed clearly that women who expressed HER-2/neu in their tissue had elevated serum levels and these levels reflected the clinical course of the patient. More extensive control studies are required to establish the role of HER-2/neu assays in the management of women with breast cancer.
Assuntos
Anticorpos Monoclonais/uso terapêutico , Antineoplásicos/uso terapêutico , Biomarcadores Tumorais/sangue , Neoplasias da Mama/tratamento farmacológico , Receptor ErbB-2/sangue , Anticorpos Monoclonais Humanizados , Neoplasias da Mama/sangue , Antígeno Carcinoembrionário/análise , Monitoramento de Medicamentos , Feminino , Humanos , Estudos Longitudinais , Mucina-1/análise , Metástase Neoplásica , Estadiamento de Neoplasias , Kit de Reagentes para Diagnóstico , Reprodutibilidade dos Testes , Estudos Retrospectivos , Sensibilidade e Especificidade , TrastuzumabRESUMO
180 patients with scoliosis (aged 12-29 years) were subjected to the correction of deformation by means of the Harringtone type distractors and spondylodesis with utilization of osseous transplants. In 24 of them (13,3%) the distractor has been broken in different terms after the operation. The danger of the break increases with the age of the patients and abruptly increases in case of scoliosis of the V degree (in excess of 90 degrees) and in case of necessity to bend the distractor to correct the kyphoscoliosis. The distractor break is associated not with the material structure but with the rod design.
Assuntos
Pinos Ortopédicos , Vértebras Lombares/cirurgia , Complicações Pós-Operatórias/etiologia , Escoliose/cirurgia , Fusão Vertebral/efeitos adversos , Vértebras Torácicas/cirurgia , Adolescente , Adulto , Criança , Falha de Equipamento , Humanos , Vértebras Lombares/anormalidades , Fusão Vertebral/instrumentação , Aço , Estresse Mecânico , Vértebras Torácicas/anormalidades , Titânio , U.R.S.S.Assuntos
Escoliose/cirurgia , Adolescente , Adulto , Feminino , Humanos , Masculino , Cuidados Pré-Operatórios , TraçãoAssuntos
Paraplegia/reabilitação , Adulto , Contratura/cirurgia , Humanos , Articulação do Joelho/cirurgia , Masculino , Paraplegia/cirurgia , PosturaAssuntos
Pré-Escolar , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Humanos , Masculino , Feminino , Cetotifeno , Rinite Alérgica Perene , Método Duplo-Cego , PlacebosAssuntos
Neoplasias Ósseas/cirurgia , Transplante Ósseo , Articulações/transplante , Adolescente , Adulto , Artrodese , Avaliação da Deficiência , Feminino , Fraturas Ósseas , Humanos , Artropatias , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias , Supuração , Transplante Homólogo , CicatrizaçãoAssuntos
Neoplasias/etiologia , Animais , Gatos , Bovinos , Transformação Celular Neoplásica/patologia , Humanos , CamundongosRESUMO
A series of tumors of the nose & paranasal sinuses in children and adolescents was studied at the Hospital Infantil de Mexico, from 1958 to 1979, obtaining the charts of 70 boys and 30 girls. The tumors were considered, according to a clinical-histological classification, as benign, intermediate and malignant neoplasias. This study included the important signs and symptoms, involved areas. diagnostic means, type of therapy (surgery or combined). The surgical technique and results were followed for at least a sufficient time, to observe a 42% recovery rate, 13% of relapses, 8% of mortality and 37% lost to follow-up, or without sufficient time to determine results. The objectives of the present paper were: to determine the importance of an early diagnosis, types of combined therapy, and present surgical techniques.
Assuntos
Neoplasias Nasais/epidemiologia , Neoplasias dos Seios Paranasais/epidemiologia , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , México , Invasividade Neoplásica , Neoplasias Nasais/patologia , Neoplasias Nasais/terapia , Neoplasias dos Seios Paranasais/patologia , Neoplasias dos Seios Paranasais/terapiaRESUMO
Se presenta una serie de neoplasias de nariz y senos paranasales en ninos y adolescentes, estudiados y tratados en el Hospital Infantil de Mexico (1958-1979), correspondiente a 70 pacientes del sexo masculino y 30 del sexo femenino. Se consideraron las neoplasias como benignas, intermedias y malignas, de acuerdo a una clasificacion clinohistologica. El estudio comprendio los sintomas y signos importantes, las areas de localizacion, los metodos de diagnostico y los tratamientos utilizados en ese lapso de tiempo. Los resultados del tratamiento en conjunto fueron seguidos en lo posible, hasta observar un 42% de curaciones, 13% de recidivas, 8% de fallecimientos por la enfermedad y 37% desconocidos o com tiempo insuficiente para concluir. El objetivo del trabajo se refiere a senalar la importancia del diagnostico temprano, del manejo adecuado en intituciones apropiadas, de comparar las actuales tecnicas de tratamiento y la experiencia de la institucion al revisar series de otros autores
