Assuntos
Peroxidação de Lipídeos , Corpo Vítreo/metabolismo , Hemorragia Vítrea/metabolismo , Animais , Antioxidantes/uso terapêutico , Avaliação Pré-Clínica de Medicamentos , Peroxidação de Lipídeos/efeitos dos fármacos , Masculino , Soluções Oftálmicas , Coelhos , Fatores de Tempo , Corpo Vítreo/efeitos dos fármacos , Hemorragia Vítrea/tratamento farmacológicoRESUMO
It has been established that one of the mechanisms of lipid peroxidation intensification is mediated by metals of variable valency, hemin compounds and phospholipids carried into the vitreous body by blood.
Assuntos
Peróxidos Lipídicos/metabolismo , Corpo Vítreo/metabolismo , Hemorragia Vítrea/metabolismo , Animais , Cobre/farmacologia , Sulfato de Cobre , Emulsões , Compostos Ferrosos/farmacologia , Hemoglobinas/metabolismo , Medições Luminescentes , Malondialdeído/metabolismo , Oxirredução/efeitos dos fármacos , Fosfolipídeos/farmacologia , Coelhos , Fatores de Tempo , Corpo Vítreo/efeitos dos fármacosRESUMO
Phylo- and ontogenetic aspects of lipid peroxidation and antioxidative enzyme system in the retina of vertebrates were studied. It was established that both the intensity of lipid peroxidation and the activity of glutathione peroxidase in the retina of different vertebrate animals (carp, frog, tortoise, pigeon, rabbit) considerably diminished with evolution. The differences in the intensity of lipid peroxidation and the activity of glutathione peroxidase between dark- and light-adapted retinas also decreased depending on the level of the development. The activity of glutathione peroxidase in the retina of chick embryos was found only at the end of the incubation period.
Assuntos
Peróxidos Lipídicos/metabolismo , Filogenia , Retina/metabolismo , Vertebrados/crescimento & desenvolvimento , Animais , Carpas , Embrião de Galinha , Columbidae , Cobaias , Coelhos , Ranidae , TartarugasRESUMO
Accumulation of lipid peroxidation (LPO) products was investigated in external and internal membranes of mitochondria with anoxia. The increase in LPO intensity in mitochondria membranes during hypoxia was shown to be more expressed in external membranes, with an active involvement of phospholipase A2 in the process revealed. Greater LPO intensity and lability of lysosomal membranes caused by contacts with mitochondria with anoxia have been established.
Assuntos
Membranas Intracelulares/metabolismo , Peróxidos Lipídicos/metabolismo , Mitocôndrias Hepáticas/metabolismo , Oxigênio/fisiologia , Animais , Técnicas In Vitro , Ratos , Ratos EndogâmicosRESUMO
The changes in lipid peroxidation of the retina have been investigated during experimental degeneration induced by monoiodoacetic acid and oxygenous intoxication. The results obtained have shown that the development of experimental degeneration of the retina is accompanied by intensification of lipid peroxidation. Injection of vitamin E both before and after monoiodoacetic acid and oxygenous intoxication leads to suppression of lipid peroxidation.
