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Virology ; 534: 114-131, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-31228725

RESUMO

Inter-genogroup reassortant group A rotavirus (RVA) strains possessing a G3 VP7 gene of putative equine origin (EQL-G3) have been detected in humans since 2013. Here we report detection of EQL-G3P[8] RVA strains from the Dominican Republic collected in 2014-16. Whole-gene analysis of RVA in stool specimens revealed 16 EQL-G3P[8] strains, 3 of which appear to have acquired an N1 NSP1 gene from locally-circulating G9P[8] strains and a novel G2P[8] reassortant possessing 7 EQL-G3-associated genes and 3 genes from a locally-circulating G2P[4] strain. Phylogenetic/genetic analyses of VP7 gene sequences revealed nine G3 lineages (I-IX) with newly-assigned lineage IX encompassing all reported human EQL-G3 strains along with the ancestral equine strain. VP1 and NSP2 gene phylogenies suggest that EQL-G3P[8] strains were introduced into the Dominican Republic from Thailand. The emergence of EQL-G3P[8] strains in the Dominican Republic and their reassortment with locally-circulating RVA could have implications for current vaccination strategies.


Assuntos
Doenças dos Cavalos/virologia , Vírus Reordenados/isolamento & purificação , Infecções por Rotavirus/veterinária , Infecções por Rotavirus/virologia , Rotavirus/isolamento & purificação , Animais , República Dominicana , Genoma Viral , Cavalos , Humanos , Filogenia , Vírus Reordenados/classificação , Vírus Reordenados/genética , Rotavirus/classificação , Rotavirus/genética , Tailândia , Proteínas Virais/genética
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