Perceived Parental Support and Psychological Control, DNA Methylation, and Loneliness: Longitudinal Associations Across Early Adolescence.

A broad range of factors have been associated with the development of adolescent loneliness. In the family context, a lack of parental support and high levels of parental psychological control have systematically been linked to loneliness. On the biological level, DNA methylation (which is an epigenetic process that suppresses gene expression) is believed to play a role in the development of loneliness. Specifically, high levels of DNA methylation in genes that play an important role in the functioning of the human stress response system are believed to elevate the risk of loneliness. Moreover, DNA methylation levels in these stress-related genes can be influenced by stressful environmental factors, suggesting a potential mediating role of DNA methylation in the association between parenting behaviors and loneliness. The current 3-year longitudinal study is the first study to examine the potential bidirectional longitudinal associations between loneliness, DNA methylation in stress-related genes, and both perceived parental support and psychological control. Furthermore, we explored the potential mediating role of DNA methylation in stress-related genes in the associations between perceived parenting and loneliness. The sample comprised 622 early adolescents (55% girls, Mage T1 = 10.77 years, SDage T1 = 0.48) who were followed from Grade 5 to 7. Parental support, psychological control, and loneliness were assessed annually by adolescent self-report questionnaires and DNA methylation was determined from saliva samples. Cross-Lagged Panel Models (CLPM) revealed that higher levels of loneliness predicted lower perceived parental support and higher perceived psychological control over time, as well as higher DNA methylation in some stress-related genes, that is, the glucocorticoid receptor gene (NR3C1) and the brain-derived neurotrophic factor (BDNF). In addition, higher NR3C1 methylation was predictive of lower perceived parental support and higher psychological control over time. No evidence was found for a mediating role of DNA methylation. Overall, our longitudinal findings challenge the current focus on DNA methylation and parenting behaviors as risk factors for adolescent loneliness. Instead, they suggest that the less considered direction of effects, which implies that loneliness predicts DNA methylation and aspects of parenting such as support and psychological control, should receive greater attention in future research.

Depression Socialization in Early Adolescent Friendships: The Role of Baseline Depressive Symptoms and Autonomous Functioning.

There is mixed evidence for depression socialization, a process by which friends affect each other's level of depressive symptoms. The current study examined whether adolescents' baseline depressive symptoms and three dimensions of autonomous functioning (autonomy, peer resistance, and friend adaptation) make adolescents more or less sensitive to depression socialization, and how these dimensions of autonomous functioning were connected. In this preregistered, two-wave longitudinal study, participants completed questionnaires on depressive symptoms, autonomy, and peer resistance and participated in a task to assess friend adaptation. Participants were 416 Dutch adolescents (Mage = 11.60, 52.8% girls) across 230 close friend dyads. In contrast to expectations, results showed no significant depression socialization nor significant moderation. Furthermore, autonomy and peer resistance were related but distinct constructs, and not related to friend adaptation. These findings suggest that there is no depression socialization in early adolescence, regardless of level of autonomous functioning.

Testing transactional processes between parental support and adolescent depressive symptoms: From a daily to a biennial timescale.

Transactional processes between parental support and adolescents' depressive symptoms might differ in the short term versus long term. Therefore, this multi-sample study tested bidirectional within-family associations between perceived parental support and depressive symptoms in adolescents with datasets with varying measurement intervals: Daily (N = 244, Mage = 13.8 years, 38% male), bi-weekly (N = 256, Mage = 14.4 years, 29% male), three-monthly (N = 245, Mage = 13.9 years, 38% male), annual (N = 1,664, Mage = 11.1 years, 51% male), and biennial (N = 502, Mage = 13.8 years, 48% male). Preregistered random-intercept cross-lagged panel models (RI-CLPMs) showed negative between- and within-family correlations. Moreover, although the preregistered models showed no within-family lagged effect from perceived parental support to adolescent depressive symptoms at any timescale, an exploratory model demonstrated a negative lagged effect at a biennial timescale with the annual dataset. Concerning the reverse within-family lagged effect, increases in adolescent depressive symptoms predicted decreases in perceived parental support 2 weeks and 3 months later (relationship erosion effect). Most cross-lagged effects were not moderated by adolescent sex or neuroticism trait level. Thus, the findings mostly support adolescent-driven effects at understudied timescales and illustrate that within-family lagged effects do not generalize across timescales.

Do You See What I See? Longitudinal Associations Between Mothers' and Adolescents' Perceptions of Their Relationship and Adolescent Internalizing Symptoms.

This 6-year community study examined how discrepancies in mothers' and adolescents' perceptions of their relationship were longitudinally associated with adolescent internalizing symptoms, and vice versa. 497 adolescents (57% boys, Mage T1 = 13.03, SDage = 0.46) and their mothers reported in 6 annual waves on conflict and warmth in the mother-adolescent relationship and adolescents reported on their depressive and Generalized Anxiety Disorder (GAD) symptoms. Latent Congruence Models suggested that both adolescent depressive and GAD symptoms significantly predicted higher levels of conflict as well as stronger discrepancies in perceptions of conflict 1-year later. In turn, higher levels of conflict significantly predicted both adolescent depressive and GAD symptoms 1-year later. For warmth, lower levels significantly predicted adolescent depressive symptoms 1-year later. Concluding, these findings suggest (1) more systematic evidence for longitudinal associations between conflict than warmth in the mother-adolescent relationship and adolescent internalizing symptoms; (2) support for a transactional model, including support for both interpersonal scar or symptom-driven effects (concerning both levels of and mother-adolescent discrepancies in conflict) and interpersonal risk or relationship-driven effects (concerning levels of both conflict and warmth); (3) longitudinal effects from adolescent internalizing symptoms to mother-adolescent discrepancies, but not vice versa; and (4) strong consistency in patterns of findings across both adolescent depressive and GAD symptoms, with few differential longitudinal associations with aspects of mother-adolescent relationship quality. Thereby, this study provides a more nuanced understanding of the direction of effects between adolescent internalizing symptoms and both levels of and discrepancies in mothers' and adolescents' perceptions of their relationship.

The future is present in the past: A meta-analysis on the longitudinal associations of parent-adolescent relationships with peer and romantic relationships.

Positive peer and romantic relationships are crucial for adolescents' positive adjustment and relationships with parents lay the foundation for these relationships. This longitudinal meta-analysis examined how parent-adolescent relationships continue into later peer and romantic relationships. Included longitudinal studies (k = 54 involving peer relationships, k = 38 involving romantic relationships) contained demographically diverse samples from predominantly Western cultural contexts. Multilevel meta-regressions indicated that supportive and negative parent-adolescent relationships were associated with supportive and negative future peer and romantic relationships. Meta-analytic structural equation modeling (k = 54) indicated that supportive parent-adolescent relationships unidirectionally predicted supportive and negative peer relationships, while negative parent-adolescent relationships were bidirectionally associated with supportive and negative peer relationships. Maintaining mutually supportive relationships with parents may help adolescents to develop positive social relationships.

Stable Anxiety and Depression Trajectories in Late Adolescence for Oral Contraceptive Users.

Background: The use of oral contraceptives (OCs) has been associated with increased incidences of anxiety and depression, for which adolescents seem to be particularly vulnerable. Rather than looking at singular outcomes, we examined whether OC use is associated with depressive and anxiety symptom trajectories from early adolescence into early adulthood. Materials and Methods: Data from 178 girls were drawn from the Research on Adolescent Development and Relationships (RADAR-Y) younger cohort study. We used assessments on 9 waves from age 13 until 24. Developmental trajectories of ratings on the Reynolds Adolescent Depression Scale (RADS-2) and the Screen for Child Anxiety Related Emotional Disorders (SCARED) were compared between never and ever users of OCs. Results: Never users showed increases in depressive and anxiety symptoms in late adolescence, whereas OC users showed a stable level of symptoms throughout adolescence. This effect remained after adjusting for baseline differences between groups in romantic relationships, sexual debut, educational level, smoking, drinking, and drug use. Age of OC use onset did not significantly predict symptom development. Conclusions: OC use in adolescence was related to an altered developmental trajectory of internalizing symptoms, in which OC users did not show an increase in depressive and anxiety symptoms in late adolescence, whereas never users did. The question remains whether this altered symptom trajectory can be considered a protective effect of OC use on psychopathology. Additional research is needed to improve our understanding of the long-term consequences of OC use on mental health.

Psychometric Qualities of the Educational Identity Processes Scale (EIPS).

In the educational domain, the development of identity becomes especially salient during school transition phases. To assess the specific identity processes that match the adolescents' experiences before and after the school transition, the Educational Identity Processes Scale (EIPS) was developed. The present study aimed to test the psychometric qualities of the EIPS by examining its factor structure, the internal and convergent validity of the identity dimensions, and whether the questionnaire was measurement invariant over time. The pre-transition version was tested in a Dutch sample (N = 242 early adolescents) and the post-transition version was tested in a Lithuanian sample (N = 1,268 mid-adolescents). Findings indicated good psychometric qualities for both the pre- and post-transition versions of the EIPS. Additionally, context dependencies were observed, as distance to the transition influenced the meaning of specific identity processes and determined whether specific processes could be considered as part of normative development.

Longitudinal Associations Between Depressive Symptoms and Quality of Romantic Relationships in Late Adolescence.

While youth with higher levels of depressive symptoms appear to have lower quality romantic relationships, little is known about longitudinal associations for both men and women. Therefore, this study used longitudinal dyadic design to examine both concurrent and longitudinal associations between depressive symptoms and positive as well as negative aspects of romantic relationship quality across two waves one- or two-years apart. The sample consisted of 149 Dutch stable heterosexual couples (149 females and 142 males participated at T1) in a stable romantic relationship in late adolescence with a mean age of 20.43 years old at the first wave. Actor-Partner Interdependence models were used to examine potential bidirectional associations over time between depressive symptoms and romantic relationship quality, above and beyond potential concurrent associations and stability of the constructs over time, from the perspective of both romantic partners. Results consistently indicated that men and women who reported higher levels of depressive symptoms perceived less positive aspects (intimacy and support) and more negative aspects (conflict) in their romantic relationship over time. In addition, unexpectedly, when men and women perceived more positive relationship aspects, their partners reported higher levels of depressive symptoms over time. These findings stress that depressive symptoms can interfere with the formation of high-quality romantic relationships.

Identity development across the transition from secondary to tertiary education: A 9-wave longitudinal study.

INTRODUCTION: The transition from secondary to tertiary education could be considered as an opportunity for psychological growth and might play a meaningful role in educational identity development during adolescence. In the present study, we aimed to examine how adolescents differ in their educational identity development across the normative transition from secondary to tertiary education in the Netherlands, and if differences between classes could be described at the socio-demographic, academic, individual, and relational level. METHOD: The present study conducted parallel process piecewise Latent Class Growth Analyses in a sample of 685 Dutch participants (47.0% girls, Mage = 17.29 years old at the time of transition). Longitudinal data from adolescent (bi)annual surveys were centered around the final year of secondary school, with 4 years before the final year and 4 years after. RESULTS: Heterogeneity in the development of identity commitment and reconsideration across the transition was best classified by a 4-class solution. These four classes were labelled Increasing Self-Certainty, Stable Self-Certainty, Post-Transition Uncertainty, and Enduring Uncertainty. Adolescents' patterns of identity development were meaningfully associated with sociodemographic, academic, individual, and relational characteristics. CONCLUSION: The present study discusses the merits of taking a person-centered approach, which indicated adaptive development for the majority of adolescents but also captured distinct patterns of struggles in educational identity development across the transition for a sizable minority.

Friend Support and Internalizing Symptoms in Early Adolescence During COVID-19.

The COVID-19 pandemic has impacted adolescents' psychosocial adjustment and social relationships across the world. This prospective longitudinal study examined whether internalizing problems during the pandemic could be predicted by precrisis friend support, and whether this effect was moderated by the time adolescents spent with their friends and COVID-19-related stress. 245 Dutch adolescents (Mage  = 11.60) participated before and during COVID-19. Higher pre-COVID-19 friend support predicted less (self-reported and parent-reported) internalizing problems during COVID-19, and this effect was not moderated by the time adolescents spent with friends or COVID-19-related stress. Friends may thus protect against developing internalizing symptoms in times of crisis. We also found the reverse effect: Internalizing problems before COVID-19 were predictive of friend support during COVID-19.

Systematically Defined Informative Priors in Bayesian Estimation: An Empirical Application on the Transmission of Internalizing Symptoms Through Mother-Adolescent Interaction Behavior.

BACKGROUND: Bayesian estimation with informative priors permits updating previous findings with new data, thus generating cumulative knowledge. To reduce subjectivity in the process, the present study emphasizes how to systematically weigh and specify informative priors and highlights the use of different aggregation methods using an empirical example that examined whether observed mother-adolescent positive and negative interaction behavior mediate the associations between maternal and adolescent internalizing symptoms across early to mid-adolescence in a 3-year longitudinal multi-method design. METHODS: The sample consisted of 102 mother-adolescent dyads (39.2% girls, M age T1 = 13.0). Mothers and adolescents reported on their internalizing symptoms and their interaction behaviors were observed during a conflict task. We systematically searched for previous studies and used an expert-informed weighting system to account for their relevance. Subsequently, we aggregated the (power) priors using three methods: linear pooling, logarithmic pooling, and fitting a normal distribution to the linear pool by means of maximum likelihood estimation. We compared the impact of the three differently specified informative priors and default priors on the prior predictive distribution, shrinkage, and the posterior estimates. RESULTS: The prior predictive distributions for the three informative priors were quite similar and centered around the observed data mean. The shrinkage results showed that the logarithmic pooled priors were least affected by the data. Most posterior estimates were similar across the different priors. Some previous studies contained extremely specific information, resulting in bimodal posterior distributions for the analyses with linear pooled prior distributions. The posteriors following the fitted normal priors and default priors were very similar. Overall, we found that maternal, but not adolescent, internalizing symptoms predicted subsequent mother-adolescent interaction behavior, whereas negative interaction behavior seemed to predict subsequent internalizing symptoms. Evidence regarding mediation effects remained limited. CONCLUSION: A systematic search for previous information and an expert-built weighting system contribute to a clear specification of power priors. How information from multiple previous studies should be included in the prior depends on theoretical considerations (e.g., the prior is an updated Bayesian distribution), and may also be affected by pragmatic considerations regarding the impact of the previous results at hand (e.g., extremely specific previous results).

Daily Identity Dynamics in Adolescence Shaping Identity in Emerging Adulthood: An 11-Year Longitudinal Study on Continuity in Development.

According to identity theory, short-term day-to-day identity exploration and commitment processes are the building blocks for long-term development of stable commitments in emerging adulthood. This key assumption was tested in a longitudinal study including 494 individuals (43% girls, Mage T1 = 13.31 years, range 11.01-14.86 years) who were followed from adolescence into emerging adulthood, covering ages 13 to 24 years. In the first five years, adolescents reported on their daily identity processes (i.e., commitment, reconsideration and in-depth exploration) across 75 assessment days. Subsequently, they reported on their identity across four (bi-) annual waves in emerging adulthood. Findings confirmed the existence of a dual-cycle process model of identity formation and identity maintenance that operated at the within-person level across days during adolescence. Moreover, individual differences in these short-term identity processes in adolescence predicted individual differences in identity development in emerging adulthood. Specifically, those adolescents with low daily commitment levels, and high levels of identity reconsideration were more likely to maintain weak identity commitments and high identity uncertainty in emerging adulthood. Also, those adolescents characterized by stronger daily changes in identity commitments and continuing day-to-day identity uncertainty maintained the highest identity uncertainty in emerging adulthood. These results support the view of continuity in identity development from short-term daily identity dynamics in adolescence to long-term identity development in emerging adulthood.

Examining intergenerational transmission of psychopathology: Associations between parental and adolescent internalizing and externalizing symptoms across adolescence.

Adolescent psychopathological (i.e., internalizing and externalizing) symptoms are quite prevalent and decrease well-being in adulthood. Parental symptoms can put adolescents at risk for developing psychopathological symptoms. This study examined the reciprocal, longitudinal associations between parental and adolescent internalizing and externalizing symptoms between and within families, using random-intercept cross-lagged panel models (RI-CLPMs). Participants were 497 Dutch adolescents (43.1% girls; Mage T1 = 13.0 years; mostly medium to high socioeconomic backgrounds) and their parents from the general population. Across six years, adolescents and their mothers and fathers reported annually on their internalizing and externalizing symptoms. Between families, maternal, but not paternal internalizing and externalizing symptoms were consistently associated with adolescent internalizing and externalizing symptoms, while within families, only increases in adolescent internalizing symptoms predicted subsequent increases in maternal internalizing symptoms. These findings suggest that associations within families differ from associations between families, and that within-family processes in the transmission of internalizing symptoms are particularly driven by adolescent-to-mother effects. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Polygenic Risk for Major Depression Interacts with Parental Criticism in Predicting Adolescent Depressive Symptom Development.

Research has focused more and more on the interplay between genetics and environment in predicting different forms of psychopathology, including depressive symptoms. While the polygenic nature of depressive symptoms is increasingly recognized, only few studies have applied a polygenic approach in gene-by-environment interaction (G × E) studies. Furthermore, longitudinal G × E studies on developmental psychopathological properties of depression are scarce. Therefore, this 6-year longitudinal community study examined the interaction between genetic risk for major depression and a multi-informant longitudinal index of critical parenting in relation to depressive symptom development from early to late adolescence. The sample consisted of 327 Dutch adolescents of European descent (56% boys; Mage T1 = 13.00, SDage T1 = 0.44). Polygenic risk for major depression was based on the Hyde et al. (Nature Genetics, 48, 1031-1036, 2016) meta-analysis and genetic sensitivity analyses were based on the 23andMe discovery dataset. Latent Growth Models suggested that polygenic risk score for major depression was associated with higher depressive symptoms across adolescence (significant main effect), particularly for those experiencing elevated levels of critical parenting (significant G × E). These findings highlight how polygenic risk for major depression in combination with a general environmental factor impacts depressive symptom development from early to late adolescence.

Intergenerational transmission: Theoretical and methodological issues and an introduction to four Dutch cohorts.

Behaviors, traits and characteristics are transmitted from parents to offspring because of complex genetic and non-genetic processes. We review genetic and non-genetic mechanisms of intergenerational transmission of psychopathology and parenting and focus on recent methodological advances in disentangling genetic and non-genetic factors. In light of this review, we propose that future studies on intergenerational transmission should aim to disentangle genetic and non-genetic transmission, take a long-term longitudinal perspective, and focus on paternal and maternal intergenerational transmission. We present four large longitudinal cohort studies within the Consortium on Individual Development, which together address many of these methodological challenges. These four cohort studies aim to examine the extent to which genetic and non-genetic transmission from the parental generation shapes parenting behavior and psychopathology in the next generation, as well as the extent to which self-regulation and social competence mediate this transmission. Conjointly, these four cohorts provide a comprehensive approach to the study of intergenerational transmission.

The Role of Stress and Mineralocorticoid Receptor Haplotypes in the Development of Symptoms of Depression and Anxiety During Adolescence.

Adolescence is a critical developmental period characterized by heightened levels of depressive and anxiety symptoms. Experiencing chronic or environmental stress, for example, as a result of traumatic events or insensitive parenting, increases the risk for depression and anxiety. However, not all adolescents develop depressive or anxiety symptoms following environmental stressors, due to differences in stress resilience. One of the factors involved in stress resilience is enhanced functionality of the mineralocorticoid receptor (MR), one of the two brain receptors for the stress hormone cortisol. High levels of MR functionality result in relatively lower rates of depression, particularly in women that experienced stress. However, much less is known about MR functionality in relation to the development of adolescent depression and to other internalizing behavior problems such as anxiety. We therefore examined whether the effects of a functional MR haplotype (i.e., the MR CA haplotype) on the development of depressive and anxiety symptoms are sex-dependent, as well as interact with environmental stressors. In a community sample of adolescents (N = 343, 9 waves between age 13 and 24), environmental stressors were operationalized as parental psychological control and childhood trauma. Results showed a sex-dependent effect of MR CA haplotype on the development of depressive symptoms but not for anxiety symptoms. MR CA haplotypes were protective for girls but not for boys. This study sheds more light on the sex-dependent effects of MR functionality related to the development of depressive and anxiety symptoms during adolescence.

A 6-Year Longitudinal Study of Adolescents and Mothers Depression Symptoms and Their Perception of Support and Conflict.

Interpersonal theories of adolescent depression assume that adolescent and maternal depression symptoms affect adolescent and maternal perceptions of their relationship quality. However, little attention has been given to examining potential bidirectional prospective associations between both adolescent and maternal perceptions of the mother-adolescent relationship and adolescent and maternal depression symptoms across adolescence. We hypothesized that the longitudinal associations between adolescent and maternal depression symptoms and adolescent and maternal perception of conflict and support in the mother-adolescent relationship would be bidirectional. In this 6-year longitudinal study, 497 adolescents (Mage = 13.03) and their mothers participated. Each year both adolescents and their mothers completed questionnaires of their depression symptoms and their perception of conflict and support in the mother-adolescent relationship. Structural equation modelling cross-lagged panel models were constructed and analyzed. The cross-lagged panel models found bidirectional longitudinal associations between adolescent depressive symptoms and higher adolescent-reported conflict and lower adolescent-reported support. In contrast, maternal depressive symptoms were only unidirectionally associated with higher maternal-reported conflict, lower maternal-reported support and higher adolescent depression symptoms. Finally, positive bidirectional longitudinal associations were found between adolescent-reported and maternal-reported conflict, and between adolescent-reported and maternal-reported support. The findings of this study are discussed in relation to Interpersonal Psychotherapy for Depressed Adolescents (IPT-A).

Parental Age and Offspring Childhood Mental Health: A Multi-Cohort, Population-Based Investigation.

To examine the contributions of maternal and paternal age on offspring externalizing and internalizing problems, this study analyzed problem behaviors at age 10-12 years from four Dutch population-based cohorts (N = 32,892) by a multiple informant design. Bayesian evidence synthesis was used to combine results across cohorts with 50% of the data analyzed for discovery and 50% for confirmation. There was evidence of a robust negative linear relation between parental age and externalizing problems as reported by parents. In teacher-reports, this relation was largely explained by parental socio-economic status. Parental age had limited to no association with internalizing problems. Thus, in this large population-based study, either a beneficial or no effect of advanced parenthood on child problem behavior was observed.

Transactional Links Between Social Anxiety Symptoms and Parenting Across Adolescence: Between- and Within-Person Associations.

This 4-year longitudinal multi-informant study examined between- and within-person associations between adolescent social anxiety symptoms and parenting (parental psychological control and autonomy support). A community sample of 819 adolescents (46.1% girls; Mage T1  = 13.4 years) reported annually on social anxiety symptoms and both adolescents and mothers reported on parenting. Between-person associations suggested that adolescent social anxiety symptoms were associated with higher adolescent- and mother-reported psychological control and lower mother-reported autonomy support. At the within-person level, however, mothers reported lower psychological control and higher autonomy support after periods with higher adolescent social anxiety symptoms. Our findings illustrate the importance of distinguishing among between-person and within-person associations and including perceptions of both dyad members in longitudinal research concerning parenting and adolescent mental health.