[Sweet's syndrome induced by pegfilgrastim during a myelodysplastic syndrome AREB2: A case report]. / Syndrome de Sweet induit par le pegfilgrastim au cours d'un syndrome myélodysplasique AREB2 : à propos d'un cas clinique.

INTRODUCTION: Sweet's syndrome is an acute neutrophilic dermatosis characterized by abrupt onset of skin lesions accompanied by fever, arthralgia, leukocytosis and diffuse neutrophilic infiltration of the dermis, as well as an excellent response to corticosteroid therapy. CASE REPORT: A 46-year-old patient with myelodysplastic syndrome was admitted for chemotherapy. On the eighth day of chemotherapy, he received a single dose of pegfilgrastim. Three days later, he developed pyrexia, conjunctivitis, arthralgia and erythematous and painful papulo-nodular lesions. Broad-spectrum empiric antibiotic therapy was started but the patient's condition deteriorated. Biology showed pancytopenia and inflammatory syndrome. Microbiological tests, autoimmune serologies and chest-computed tomography were negative. Cutaneous biopsy was compatible with Sweet's syndrome. A diagnosis of Sweet's syndrome induced by pegfilgrastim was made and intravenous corticosteroid therapy was started with a rapid favorable outcome. CONCLUSION: Sweet's syndrome is a rare adverse effect of G-CSF.

[Management of posteriorly dislocated lens material after complicated phacoemulsification. The vitreoretinal surgeon's point of view]. / Conduite à tenir face à une phakoémulsification compliquée d'une luxation postérieure de matériel cristallinien. Le point de vue du chirurgien vitréorétinien.

Posterior dislocation of lens material is a serious complication of phacoemulsification. Its prognosis depends on timely treatment, well-planned by cataract and vitreoretinal surgeons working in collaboration. Pars plana vitrectomy with removal of the dislocated material is nearly always mandatory on a short-term basis in order to prevent and/or treat any further complication, mainly uveitis, hypertony, corneal edema, cystoid macular edema, and retinal detachment. The best time to implant and perform pars plana vitrectomy is still a matter of controversy. The best predictor of final visual acuity is the visual acuity before vitrectomy.