[Effect of the level of free-radical lipid peroxidation on the ribonucleotide reductase activity of liver tissue]. / Vliianie urovnia svobodnoradikal'nykh protsessov okisleniia lipidov na ribonukleotidreduktaznuiu aktivnost' tkani pecheni.

The dynamics of RNA and DNA synthesis as well as the activity of free radical processes in rat liver during the first 40 hours after partial hepatectomy was studied. It was shown that RNA synthesis activation follows the activation of lipid peroxidation (LPO), whereas the DNA synthesis activation follows the decrease of the LPO level. These facts are suggestive of the dependence of the ribonucleotide reductase (RNR) activity on free radical processes. This observation was confirmed by a RNR activity analysis of regenerating liver homogenates. The activity peak was shown to precede the peak of DNA synthesis. Evidence for free radical RNR suppression was also obtained in direct experiments, using intact animal liver homogenates, to which a natural antioxidant (tocopherol) was added.

[Role of erythrocyte membrane cholesterol in disorders of their structuro-functional status in patients with ischemic heart disease]. / Rol' kholesterina membran éritrotsitov v narushenii ikh strukturno-funktsional'nogo sostoianiia u bol'nykh ishemicheskoi bolezn'iu serdtsa.

Increased molar cholesterol/phospholipid ratios, significantly increased membrane microviscosity, reduced filterability through a 3 micron-pore filter, increased aggregation and longer disaggregation time, and occasional abnormally large cells were found in erythrocyte assays of 80 coronary patients, as compared to normal subjects. It is suggested that erythrocyte microrheologic disorders are related to excessive cellular cholesterol content in coronary patients.

[Comparison of the accuracy of DNA copying in the course of semiconservative and repair synthesis using an analysis of the distribution of radioactive precursors]. / Sravnenie tochnosti kopirovaniia DNK v khode polukonservativnogo i reparativnogo sinteza putem analiza raspredeleniia radioaktivnogo predshestvennika.

The analysis of 3H-thymidine incorporation into liver and heart DNA has shown the possible errors occurring during repair synthesis in pyrimidine oligonucleotides.

[Cytophotometric analysis of the chromatin structural conformity in interphase nuclei detected in UV light and by gallocyanine staining]. / Tsitofotometricheskii analiz sootnovetstviia struktury khromatina interfaznykh iader, vyiavliaemoi v UF-svete i pri okrashivanii gallotsianinom.

Geometric and optical parameters of chromatin of hepatocyte nuclei have been examined before (UV, lambda = 265 nm) and after gallocyanine staining. Quantitative parameters of the chromatin structure in the same nuclei measured in situ by a scanning microscope-photometer (step size 0.125 micron) before and after staining were equal. Tinctorial properties of chromatin granules (condensed part of the nuclear material) and its diffuse part were different. It is suggested that the difference between granules and the nongranular part of chromatin is not only of optical but also of chemical nature.

[Blast transformation of lymphocytes in panarteritis of the aorta and its branches]. / Blasttransformatsiia limfotsitov pri panarterite aorty i ee vetvei

In 49 patients with panarteritis of the aorta and its branches the reaction of blast-transformation as one of the indicators of the immune system condition, of T-lymphocytes in particular, was studied. A definite significance of the lymphocytes blast-transformation reaction in confirming the autoimmune element in the pathogenesis of panarteritis of the aorta and its branches was established.