RESUMO
While there are 35,000 diagnosed oral cancers per year and 7,500 deaths, there are 30 times this amount when it comes to cases of skin cancer, the majority of which are found on the head and neck. Because many patients see their dentist more frequently than their medical doctor, dentistry is in an advantageous position to reduce the mortality/morbidity of this most common malignancy. This article discusses various types of head and neck skin cancer and how dental practitioners can perform clinical examinations to provide early detection for patients.
Assuntos
Odontólogos , Detecção Precoce de Câncer , Neoplasias de Cabeça e Pescoço/diagnóstico , Neoplasias Cutâneas/diagnóstico , Idoso , Carcinoma Basocelular/diagnóstico , Carcinoma Basocelular/etiologia , Carcinoma Basocelular/prevenção & controle , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/etiologia , Carcinoma de Células Escamosas/prevenção & controle , Odontologia , Feminino , Neoplasias de Cabeça e Pescoço/etiologia , Neoplasias de Cabeça e Pescoço/prevenção & controle , Humanos , Melanoma/diagnóstico , Melanoma/etiologia , Melanoma/prevenção & controle , Fatores de Risco , Neoplasias Cutâneas/etiologia , Neoplasias Cutâneas/prevenção & controle , Luz Solar/efeitos adversosRESUMO
BACKGROUND: LL-37 is a peptide belonging to the cathelicidin family of antimicrobial peptides. Recent investigations have suggested that the expression of antimicrobial peptides is an important mechanism for resistance to microbial infection. OBJECTIVE: The aim of this study was to determine whether LL-37 is expressed in papillomavirus-infected epidermis from patients with condyloma acuminatum or verruca vulgaris. METHODS: Biopsy specimens from 3 patients with condyloma and 2 patients with verruca vulgaris and 6 normal skin samples were studied by immunostaining with an antibody specific to LL-37 and control rabbit serum. Western blots were performed on skin extracts from normal skin and verrucae. RESULTS: A large increase in the expression of LL-37 was seen within keratinocytes of all involved samples and in the extracts of verrucae analyzed by Western blot. CONCLUSION: This study shows the antimicrobial peptide LL-37 is induced within the epidermis during the development of verruca vulgaris. This expression represents a previously unknown immunologic response to papillomavirus infection and may represent an important step in the pathogenesis of this disorder.
Assuntos
Peptídeos Catiônicos Antimicrobianos/análise , Condiloma Acuminado/metabolismo , Queratinócitos/química , Verrugas/metabolismo , Western Blotting , Catelicidinas , Epiderme/química , Humanos , Imuno-HistoquímicaRESUMO
The development of skin manifestations of diabetes affects up to two thirds of patients with both types 1 and 2 diabetes mellitus. Cutaneous manifestations of diabetes occur because of the microvascular complications of diabetes, impaired wound healing, and other yet undetermined mechanisms. This article summarizes the most frequent skin findings in patients with diabetes, and proposes treatment of some complications.
