RESUMO
The paper deals with the carcinostatic and immunomodifying action of synthetic polyelectrolytes containing acid and basic groups as well as of polyampholytes and nonionogenic polymers. Polyacrylic acid was found to possess the highest antitumour and adjuvant activity. The antitumour effect of polyacrylic acid increases with its molecular mass. Introduction of other polymers into a polymer chain of acrylic acid results in a decrease in its antitumour and immunoadjuvant action.
Assuntos
Resinas Acrílicas , Adjuvantes Imunológicos , Antineoplásicos , Resinas Acrílicas/imunologia , Resinas Acrílicas/uso terapêutico , Adjuvantes Imunológicos/imunologia , Animais , Antineoplásicos/uso terapêutico , Neoplasias Hepáticas Experimentais/tratamento farmacológico , CamundongosAssuntos
Adjuvantes Imunológicos/uso terapêutico , Antineoplásicos/uso terapêutico , Neoplasias Experimentais/tratamento farmacológico , Polímeros/uso terapêutico , Animais , Avaliação Pré-Clínica de Medicamentos , Neoplasias Hepáticas Experimentais/tratamento farmacológico , Melanoma/tratamento farmacológico , Camundongos , Camundongos Endogâmicos C3H , Camundongos Endogâmicos C57BL , Transplante de NeoplasiasAssuntos
Antibacterianos/uso terapêutico , Antineoplásicos/uso terapêutico , Infecções Bacterianas/prevenção & controle , Gentamicinas/administração & dosagem , Leucemia/complicações , Isolamento de Pacientes , Doença Aguda , Administração Oral , Adulto , Antineoplásicos/efeitos adversos , Daunorrubicina/uso terapêutico , Feminino , Humanos , Injeções Intravenosas , Leucemia/tratamento farmacológico , Masculino , Neutropenia/induzido quimicamenteRESUMO
Content of thiamine and activities of two enzymes were studied in blood cells of patients with various types of leukosis. In patients with acute leukemia content of thiamin was decreased in leucocytes and blood plasma. Content of vitamin B1 was increased in erythroid cells of peripheric blood in erythroleukosis. Administration of thiamin into some patients caused a distinct increase in its content in blood cells. The guanosine phosphorylase activity was higher in blood cells in leukosis as compared with control. The transketolase activity was not distinctly altered.