[Morphological diagnosis of DIC syndrome. Shock liver]. / Morfologicheskaia diagnostika DVS-sindroma. Shokovaia pechen'.

A total of 140 pathoanatomic conclusions and files collected by the author are analyzed. Morphological signs of the DIC syndrome were detected in 55% of patients who died. In 42% of lethal outcomes this syndrome was the final direct cause of death after such conditions as terminal stage of cancer, sepsis, extensive myocardial infarction, mechanical jaundice, uremia, bacteremia, etc. In 13% of autopsies fatal intravascular coagulation was a complication of the intervention or hemorrhage which was arrested before death. The DIC syndrome is diagnosed during autopsy due to a complex of peculiar changes in the viscera which are called "shock" in such cases. The signs of a shock liver are as follows: a characteristic red net pattern of the sliced surface and histological phenomena related to blocking of the sinusoidal bloodflow and lobular ischemia: abnormal hepatocyte complexes, fragmentation of liver bulks, and necrosis of the central lobules.

[Clinical, radiologic and morphologic characteristics of localized forms of pulmonary tuberculosis. Tuberculosis and hypoplasia]. / Kliniko-rentgeno-morfologicheskaia kharakteristika ogranichennykh form tuberkulëza lëgkikh. Tuberkulëz i gipoplaziia.

Clinical and x-ray examinations and study of operation material from 555 patients with local forms of tuberculosis permitted the authors to distinguish three form of the condition: tuberculoma (77% of cases), cavitary (cavernous) tuberculosis (16%), and tuberculosis of the bronchi (5%). Morphologic investigations showed the local tuberculosis develops at small sites of pulmonary tissue hypoplasia. Sites of hypoplasia are usually concentrated in the pulmonary segments which are formed in the postnatal period, thus explaining the typical localization of a postprimary tuberculous focus. Tissue decomposition with development of destruction cavities is not characteristic of local tuberculosis. Cavitary (cavernous) form is a morphologic reflection of a tuberculous inflammation in the zone of cestous hypoplasia. Morphonesis of local forms of tuberculosis reflects its social dependence.

[Developmental disorders of the lungs and tuberculosis]. / Poroki razvitiia legkikh i tuberculez.

Surgical biopsy of 536 pulmonary tuberculosis patients was analysed. It was found that in 90% of them tuberculosis developed in the malformed segment of lung tissue. Among the defects, basic matter was composed of small hypoplasia zones (2-3 cm) which were detected only morphologically. In 89% of the cases, zones of hypoplasia and cysts were located in the 1st and 2nd lung segments, which formed in the first postnatal months. In all cases tuberculosis affected the malformed bronchus, which was probably the primary site of tuberculosis process dissemination.

[Morphological manifestations of the immune reactions in stomach cancer and their relation to the histological structure of the tumor]. / Morfologicheskie proiavleniia immunnykh reaktsii pri rake zheludka ikh sviaz' s gistologicheskim stroeniem opukholi.

The morphology of immune response in tumor tissue was studied in the resected material obtained from 244 patients with stomach cancer. In nearly 80% of cases of carcinoma, the following five morphological types were observed: (1) acute inflammation (immediate--onset hyperergy); (2) time--delayed hyperergy; (3) plasmocytic--eosinophilic cellular infiltration with tumor mucination; (4) chronic granulomatous inflammation and (5) lymphadenoid and fibrose tissue envelope of tumor. There established a relationship between the type and degree of immune reactions and the histology of tumor. Progressing, regressing and stable reactions should be distinguished. Tumor regression and immune response were observed in foci; however, complete resolution was registered in 2.5% of cases only.

[Histological structure of early stomach cancer]. / Gistologicheskoe stroenie rannego raka zheludka.

On the material of 144 cases of early gastric cancer its two main histological types are described: enterocellular and mucoidocellular (diffuse). Both these types are differed one from the other by trends of differentiation of tumor cells with the maintained covering function of the epithelium in intestinal carcinoma and the secretory function--in mucoid one. Intestinal cancer shows the structure of adenocarcinoma and is characterized by an expansive exophytic growth. Mucoid carcinoma produces fibrous bands, chains and free cell clusters and shows an endophytic, diffuse-infiltrative growth. In intestinal and mucoid type of cancer a stable (differentiated), progressive (actively proliferating) and regressive variants can be distinguished, the development of which is closely related with local immune reactions in the gastric wall.