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1.
Actas Esp Psiquiatr ; 52(3): 301-308, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38863046

RESUMO

BACKGROUND: The legalization of cannabis use and false claims about the plant Cannabis sativa to be considered a pharmaceutical product have been found to increase consumption, lower risk perception, and lead to more health problems, without reducing criminal activity. Brain function, typically assessed by neuropsychological tests, shows abnormalities with acute marijuana use, but inconsistent results have been published after abstinence, with a maximum follow-up of 28 days. Our previous research, using neuropsychological tests and brain perfusion single photon emission computed tomography (neuroSPECT), demonstrated consistent abnormalities in brain function among schoolchildren who consume marijuana compared to their non-consuming peers. The aim of this study is to investigate whether brain function changes in 20 adult marijuana users after 6 months of abstinence. METHODOLOGY: Comparison of neuropsychological tests (Rey Complex Figure; Porteus Maze; Four subtests of WAIS-IV Intellectual Tests; STROOP; D2) and perfusion neuroSPECT (functional images), obtained in relation to recent consumption and after 6 months of serial drug-screening test confirmed abstinence. RESULTS: In a one-year period (2020-2021) only five compliant participants were recruited. The COVID-19 pandemic was a limiting factor. Preliminary results of neuropsychological tests, functional brain perfusion images and limited statistical analysis are presented. The results of the neuropsychological tests of the three subjects who completed the abstinence period so far show some improvement in working memory and attention after abstinence. NeuroSPECT shows disorganized hypoperfusion of variable severity in relation to recent consumption, involving areas associated with cognitive function such as the posterior cingulate and temporal lobes, in our five initially enrolled patients, when compared to a normal database. Of these, only two participants have already been re-evaluated with neuroSPECT after 6 months of abstinence, one of whom showed some improvement on the post-abstinence images. CONCLUSION: We analyze the methodological challenges of this research, including the pandemic, to incorporate the appropriate corrections in the next phase of our investigation. Our final findings may provide clinicians and users with information about the long-term effects of marijuana use on brain function.


Assuntos
Encéfalo , Testes Neuropsicológicos , Humanos , Masculino , Adulto , Feminino , Encéfalo/diagnóstico por imagem , Encéfalo/efeitos dos fármacos , Adulto Jovem , Tomografia Computadorizada de Emissão de Fóton Único , Uso da Maconha , COVID-19 , Fatores de Tempo
2.
Salud ment ; 36(5): 367-374, sep.-oct. 2013. ilus, tab
Artigo em Espanhol | LILACS-Express | LILACS | ID: lil-703501

RESUMO

Comparative study based on 565 adolescent school children coming from four schools in the metropolitan area of Santiago, Chile. All were interviewed in order to select a sample that was stratified for sex, class and condition of consumer or non-consumer. The variables of intellectual coefficient and socioeconomical level were maintained constant. With this selection we conformed two groups: 40 consumers exclusively of marihuana and 40 non-consumers. We compared the results obtained in both groups in the neuropsychological tests while the neuroSPECT studies of consumers were compared against a normal database for the same age group. The adolescent consumers of marihuana demonstrate less cognitive capacity related to the process of learning such as attention, concentration, ranking, viso-spatial integration, immediate retention and visual memory. The differences between both groups are statistically significant. The findings of neuroSPECT demonstrate subgenual hypoperfusion bilaterally, more marked on the left side, in area 25 of Brodmann. This area controls mood. There is also frontal bilateral hypoperfusion (area 10 and area 32 of Brodmann). Area 32 is pre-anterior cingulate gyrus. Also hypoperfusion of the anterior cingulate gyrus (area 24 of Brodmann) and hypoperfusion of area 36 of Brodmann that projects over the hippocampus. Students that were consumers exclusively of marihuana demonstrate coincident abnormal findings of neuroimages and neuropsychological tests in areas of the brain related with learning and also significant differences between consumers with non-consumers in the neuropsychological tests.


Estudio comparativo basado en 565 escolares adolescentes pertenecientes a cuatro colegios de Santiago, Chile. Fueron encuestados todos para seleccionar una muestra estratificada por sexo, curso y condición de consumidores o no consumidores, manteniendo constante las variables coeficiente intelectual y nivel socioeconómico. Se conforman dos grupos: 40 consumidores exclusivos de marihuana y 40 no consumidores. Se comparan los resultados obtenidos en ambos grupos en los Test Neuropsicológios y del NeuroSPECT de consumidores con una base de datos considerados normales para el mismo grupo etario. Los adolescentes consumidores de marihuana evidencian menores habilidades cognitivas asociadas al proceso de aprendizaje, tales como atención, concentración, jerarquización, integración visoespacial, retención inmediata y memoria visual. Las diferencias entre ambos grupos son estadísticamente significativas. Los hallazgos del NeuroSPECT muestran hipoperfusión subgenual bilateral, más marcada en el hemisferio izquierdo (área 25 de Brodmann), hipoperfusión frontal bilateral (areas 10 y 32 de Brodmann), hipoperfusión del gyrus cingulado anterior (área 24 de Brodmann) e hipoperfusión del área 36 de Brodmann que proyecta sobre el hipocampo. Los estudiantes consumidores exclusivamente de marihuana muestran compromiso coincidente en neuroimágenes y test neuropsicológicos en áreas del cerebro relacionadas con el aprendizaje y se diferencian significativamente de los no-consumidores en las pruebas neuropsicológicas.

3.
Acta Otolaryngol ; 131(4): 371-6, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21314243

RESUMO

CONCLUSIONS: Our observations support the concept of bilateral cortical activation with monaural and binaural auditory stimulation. The observation that most of the significantly activated areas were the same with monaural or binaural stimulation suggests that the differences in auditory perception with binaural stimulation are not due to the involvement of significantly different processing centers but, more likely, to the type of information that reaches these centers for processing. The observation that the degree of stimulation was less intense in binaural than in monaural stimulation supports the concept that a richer binaural auditory stimulation compared with monaural stimulation does not mean summation of stimuli but integration and better processing of the information. For normal bilateral hearing subjects, a monaural stimulus is an uncommon event and may thus explain the more intense response. The repeatability of the results for monaural and binaural stimulation with pure tones in the same subjects confirms the consistency of the testing method. OBJECTIVES: (1) To determine which areas of the cerebral cortex and basal ganglia are activated by binaural stimulation with pure tones (left and right ear simultaneously) and what type of response occurs (e.g. excitatory or inhibitory) in these different areas. (2) To determine the degree of ipsilateral and/or contralateral cortical activation and/or inhibition. (3) To compare the data with our previous reports of monaural stimulation using the same technique and the same subjects. (4) To evaluate the consistency of our testing method. METHODS: Brain perfusion single photon emission computed tomography (SPECT) evaluation was conducted using auditory binaural stimulation with pure tones in six normal volunteers. Both ears were stimulated simultaneously. Tc99m HMPAO was injected while pure tones were delivered and the SPECT imaging was done 1 h later. RESULTS: After delivering pure tones there was bilateral activation in Brodmann areas 7 (somatosensory association cortex), 9 and 10 (executive frontal areas), 17, 18, and 19 (associative visual cortex). There was also activation in temporal areas 21, 22 (auditory association areas), and parietal areas 39 and 40 (Wernicke). There was also marked activation in both thalami. These activated areas were the same as those in our previous reports with monaural stimulation in the same subjects. However, except for areas 17, 18, 23, 31, and 32 (which remained over 4 SD above the normal maximum), the degree of activation was less intense in binaural compared with monaural stimulation. Inhibition was also less intense in binaural stimulation.


Assuntos
Estimulação Acústica , Vias Auditivas/fisiologia , Percepção Auditiva/fisiologia , Adulto , Córtex Auditivo/fisiologia , Gânglios da Base/fisiologia , Feminino , Audição , Humanos , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada de Emissão de Fóton Único , Adulto Jovem
4.
Acta Otolaryngol ; 129(4): 348-53, 2009 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-18985461

RESUMO

CONCLUSIONS: 1.With auditory stimuli cortical activation of Brodmann's areas 39 and 40 and inhibition of area 38 is bilateral. Inhibitory and excitatory relays play a role in the auditory pathways. 2. A statistically significant increased activation on the left side in areas 39 and 40, regardless of the stimulated ear, is suggestive that pure tones are preferably processed in the left hemisphere. 3. The significant difference in central inhibition depending on which ear is stimulated is supportive of the idea of a leading ear. OBJECTIVES: The objectives were to determine cortical activation/inhibition, ipsi/contralateral in response to monaural stimulation with pure tones, and if the response differs for right/left ear stimulation. SUBJECTS AND METHODS: Tc99m-HMPAO brain perfusion SPECT was done during monaural stimulation with pure tones in 10 volunteers. Ears were tested independently. RESULTS: During auditory stimulation perfusion increased in both hemispheres in Brodmann's areas 39-40 and decreased in area 38,>2 SD above and below the normal mean respectively, in both hemispheres, regardless of which side was stimulated. A significantly more intense response was seen in left versus right in areas 39 and 40. In area 38 there was bilateral inhibition, significantly more intense in response to left than right ear stimulation.


Assuntos
Estimulação Acústica , Córtex Auditivo/fisiologia , Orelha/fisiologia , Lateralidade Funcional , Adulto , Humanos , Pessoa de Meia-Idade , Tomografia Computadorizada de Emissão de Fóton Único , Adulto Jovem
5.
Acta Otolaryngol ; 127(7): 711-21, 2007 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-17573567

RESUMO

CONCLUSIONS: Our observations confirm that musical sensations with no external stimuli, either spontaneous or evoked, occur in normal individuals and that a biological substrate can be demonstrated by brain single photon emission computed tomography (SPECT). OBJECTIVES: There are individuals, usually musicians, who are seemingly able to evoke and/or have spontaneous musical sensations without external auditory stimuli. However, to date there is no available evidence to determine if it is feasible to have musical sensations without using external sensory receptors, or if there is a biological substrate for these sensations. SUBJECTS AND METHODS: A group of 100 musicians and another of 150 otolaryngologists were asked if they had spontaneous musical auditory sensations and/or were capable of evoking them. SPECT evaluations with Tc(99m)-HMPAO were conducted in six female musicians while they were evoking these sensations or, in one case, while she was having them spontaneously. In three of them an additional SPECT was conducted in basal conditions (having been asked to avoid evoking music). RESULTS: In all, 97 of 100 musicians had spontaneous musical sensations; all 100 could evoke and modify them. Of the 150 otolaryngologists, 18 (12%) were musicians. Of the 132 nonmusicians, spontaneous musical sensations occurred in 52 (39.4%), 72 (54.5%) could evoke and 23 (17.4%) were able to modify them, 58 (43.9%) did not have spontaneous musical sensations nor could they evoke them. The musical sensations of the 72 otolaryngologists that could evoke were less elaborated than those of musicians. NeuroSPECT during voluntary musical autoevocation demonstrated significant (>2 SD) increased activation of executive frontal cortex in Brodmann areas 9 and 10, secondary visual cortex (area 17), and paracingulate (areas 31 and 32). There was also activation in the para-executive frontal cortex (areas 45 and 46). In the basal ganglia there was activation in thalamus and lentiform nucleus. Deactivation below 2 SD was demonstrated by mean values in the cingulate gyrus, Brodmann areas 23 and 24, and subgenual area 25. Deactivation was also demonstrated when minimal values were analyzed in the same areas plus area 4 and areas 36 and 38, the latter in the pole of the temporal lobes. In three patients comparison of basal state with autoevocation demonstrated activation in executive frontal cortex (areas 8 and 9), para-executive cortex (area 45), primary auditory cortex (area 40), the right thalamus, and lentiform nucleus.


Assuntos
Encéfalo/diagnóstico por imagem , Encéfalo/fisiologia , Potenciais Evocados/fisiologia , Imaginação/fisiologia , Música/psicologia , Estimulação Acústica , Adulto , Idoso , Percepção Auditiva/fisiologia , Mapeamento Encefálico , Estudos de Viabilidade , Feminino , Humanos , Memória/fisiologia , Pessoa de Meia-Idade , Tomografia Computadorizada de Emissão de Fóton Único
6.
Rev. med. nucl. Alasbimn j ; 8(33)julio 2006. ilus, tab
Artigo em Inglês | LILACS | ID: lil-444096

RESUMO

Existen personas, generalmente músicos, que tienen la capacidad de evocar sensaciones musicales sin un estímulo auditivo externo. Sin embargo, hasta la fecha no hay evidencias que sugieran que sea posible tener estas sensaciones, ni que exista un sustrato biológico para ellas. Diseño del trabajo: Se hicieron dos estudios de neuroSPECT con [99mTc]-HMPAO en cada una de tres mujeres músicos. El primer estudio fue hecho en condiciones basales (sin evocar) y el segundo mientras estaban evocando sensaciones musicales. Resultados: En el estudio de las voluntarias que fueron evaluadas mientras evocaban una composición musical, hubo un aumento significativo de perfusión en los hemisferios derecho e izquierdo en las áreas de Brodmann 9 y 8 (área ejecutiva frontal) y en el área 40 en el lado izquierdo (área auditiva). Sin embargo, en condiciones basales no hubo aumento de perfusión en las áreas 9, 8, 39 y 40. En un caso hubo mayor aumento de perfusión en el área 45 durante la autoevocación respecto a la condición basal. Conclusiones: Estos hallazgos son sugerentes de un sustrato biológico para el proceso de evocar sensaciones musicales.


Assuntos
Adulto , Humanos , Feminino , Idoso , Tomografia Computadorizada de Emissão de Fóton Único , Córtex Auditivo , Córtex Auditivo/fisiologia , Estimulação Acústica , Potenciais Evocados Auditivos/fisiologia , Cérebro , Cérebro/fisiologia , Música , Testes Auditivos , Rememoração Mental , Sensação
7.
Acta Otolaryngol ; 126(4): 368-74, 2006 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-16608788

RESUMO

CONCLUSIONS: Spontaneous musical auditory perceptions commonly occur in patients who develop abrupt bilateral sensorineural hearing loss. The findings in both subjects who were image tested while having these perceptions are suggestive of a biological substrate for this process and of a central locus for auditory memory seemingly located in and around area 39 of Brodmann. When an individual has abrupt bilateral sensorineural hearing loss, stored musical memory can be released and this person can have musical perceptions without an external source. It is likely that an abrupt bilateral loss of inner ear function might uninhibit neuronal groups storing auditory memory. OBJECTIVES: The objectives of this study were as follows. (1) To determine if spontaneous musical auditory perceptions occur in patients who develop abrupt bilateral severe sensorineural hearing loss (not necessarily simultaneously). (2) To determine if there is a biological substrate to the process of recalling previous auditory perceptions. (3) To compare these findings with our normal databases of unstimulated and pure tone-stimulated volunteers. (4) To establish a hypothesis for the mechanisms of these occurrences. PATIENTS AND METHODS: Thirty two patients who had had abrupt bilateral severe sensorineural hearing loss (the interval between the losses of both ears could have been years) were contacted. They were asked if they had ever had the sensation of having musical auditory perceptions without external auditory stimuli. Two of these patients were image tested with single photon computerized emission tomography (neuroSPECT) while they were having these perceptions. RESULTS: All of the 32 subjects had musical auditory perceptions following their hearing loss in the second ear or when hearing loss in both ears occurred simultaneously. The two patients who were image tested with neuroSPECT had similar findings. There was a statistically significant increase in perfusion in area 39 of Brodmann, more intense on the right side, with increased perfusion also in both frontal lobes at the middle gyrus, with bilateral hypoperfusion in area 38 of Brodmann. These findings are similar to those observed in normal volunteers stimulated with pure tones.


Assuntos
Córtex Auditivo/fisiopatologia , Percepção Auditiva/fisiologia , Perda Auditiva Bilateral/fisiopatologia , Perda Auditiva Neurossensorial/fisiopatologia , Perda Auditiva Súbita/fisiopatologia , Música , Estimulação Acústica/psicologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Memória , Pessoa de Meia-Idade , Tomografia Computadorizada de Emissão de Fóton Único
8.
Acta Otolaryngol ; 125(5): 513-9, 2005 May.
Artigo em Inglês | MEDLINE | ID: mdl-16092543

RESUMO

CONCLUSIONS: Bilateral activation of Brodmann area 39 provides functional support for the concept of bilateral cortical activation with auditory stimulation. The observation that when Brodmann area 39 is activated, area 38 of the temporal lobe is simultaneously inhibited (a functional observation that has seemingly not been previously reported) supports the concept that inhibitory as well as excitatory relays play a role in the auditory pathways. In addition, this report helps to establish a functional database for future studies. OBJECTIVES: (i) To determine which areas of the cerebral cortex and basal ganglia are activated when the left and right ears are monaurally stimulated with pure tones, and what type of response (e.g. excitatory or inhibitory) occurs in these different areas. (ii) To determine the degree of ipsi- and/or contralateral cortical activation and/ or inhibition depending on the ear that is stimulated. (iii) To use this information as an initial step to develop a normal functional database for future studies. MATERIAL AND METHODS: A brain perfusion single-photon emission CT (SPECT) evaluation was conducted using auditory monaural stimulation with pure tones in 10 normal volunteers. Both ears were tested independently (20 examinations in total). 99mTc hexamethyl-propylenamine-oxime was injected while pure tones were delivered, and the SPECT imaging was done 1 h later. RESULTS: After delivering pure tones there was bilateral cortical activation in Brodmann areas 39 and 40, regardless of which ear was stimulated. Despite marked hyperperfusion in both areas 39, a more intense response was seen on the left compared to the right side, although this was not statistically significant. There was also activation in the executive frontal cortex areas 9 and 10 as well as in the temporal Brodmann areas 21 and 22. Simultaneously, area 38 of the temporal lobe was deactivated. In the subcortical structures there was also marked activation in both thalami and deactivation of the caudate nuclei without lateralization.


Assuntos
Córtex Auditivo/metabolismo , Vias Auditivas/metabolismo , Encéfalo/metabolismo , Lateralidade Funcional/fisiologia , Estimulação Acústica , Adulto , Audiometria de Tons Puros , Bases de Dados como Assunto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Oximas , Oxigênio/metabolismo , Compostos Radiofarmacêuticos , Lobo Temporal/irrigação sanguínea , Tomografia Computadorizada de Emissão de Fóton Único
9.
Rev. med. nucl. Alasbimn j ; 7(28)apr. 2005. ilus
Artigo em Espanhol | LILACS | ID: lil-444062

RESUMO

La localización de una lesión de la calota craneana puede ser difícil en especial cuando es pequeña y poco evidente a nivel de la superficie externa del cráneo. En este artículo se describe la localización y extirpación guiada por cintigrafía intraoperatoria, de una lesión de 2 cm que comprometía la cara interna del hueso temporal. La expresión radiológica de la lesión en la radiología simple y en la tomografía computada era pobre. Esto hizo difícil la radiología intraoperatoria y la neuronavegación guiada por tomografía computada. En el presente caso se logró extirpar la lesión en bloque. La biopsia fue informada como "Enfermedad de Paget". No hubo complicaciones quirúrgicas.


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Crânio/lesões , Neuronavegação/instrumentação , Osteíte Deformante/cirurgia , Osteíte Deformante/diagnóstico , Cirurgia Assistida por Computador/instrumentação , Procedimentos Neurocirúrgicos/instrumentação , Tomografia Computadorizada por Raios X
10.
Transplantation ; 78(4): 503-8, 2004 Aug 27.
Artigo em Inglês | MEDLINE | ID: mdl-15446307

RESUMO

BACKGROUND: The use of mesenchymal stem cells (MSC) for cell therapy relies on their capacity to engraft and survive long-term in the appropriate target tissue(s). Animal models have demonstrated that the syngeneic or xenogeneic transplantation of MSC results in donor engraftment into the bone marrow and other tissues of conditioned recipients. However, there are no reliable data showing the fate of human MSC infused into conditioned or unconditioned adult recipients. METHODS: In the present study, the authors investigated, by using imaging, polymerase chain reaction (PCR), and in situ hybridization, the biodistribution of human bone marrow-derived MSC after intravenous infusion into unconditioned adult nude mice. RESULTS: As assessed by imaging (gamma camera), PCR, and in situ hybridization analysis, the authors' results demonstrate the presence of human MSC in bone marrow, spleen, and mesenchymal tissues of recipient mice. CONCLUSIONS: These results suggest that human MSC transplantation into unconditioned recipients represents an option for providing cellular therapy and avoids the complications associated with drugs or radiation conditioning.


Assuntos
Células da Medula Óssea/citologia , Transplante de Células-Tronco Mesenquimais , Células-Tronco Mesenquimais/citologia , Transplante Heterólogo , Animais , DNA/análise , Feminino , Humanos , Hibridização In Situ , Camundongos , Camundongos Nus , Reação em Cadeia da Polimerase , Baço/citologia
11.
Rev. med. nucl. Alasbimn j ; 6(25)julio 2004. ilus, tab, graf
Artigo em Espanhol | LILACS | ID: lil-444050

RESUMO

Objetivos. 1. Determinar que áreas de la corteza cerebral son activadas al estimular el oído izquierdo con tonos puros, y que tipo de estimulación ocurre (eg. excitatoria o inhibitoria) en estas diferentes áreas. 2. Usar esta información como una etapa inicial para desarrollar una bases de datos funcional para estudios futuros. 3. Tratar de determinar si existe un sustrato biológico para el proceso de recordar percepciones auditivas previas, y si fuera posible, sugerir un locus para la memoria auditiva. Método. Se hicieron evaluaciones de SPECT: 1-2) Usando estimulación auditiva con tonos puros en 4 voluntarias con audición normal. 3) En una paciente con sordera profunda bilateral, la cual tenía percepciones auditivas de experiencias musicales previas; mientras estaba teniendo la sensación de escuchar una melodía conocida. Resultados. Tanto en la paciente con alucinaciones auditivas como en las voluntarias estimuladas con tonos puros, hubo una diferencia estadísticamente significativa en perfusión del área 39 de Brodmann; más intensa en el lado derecho (derecho a izquierdo p <0.05). Con menor intensidad hubo también activación en el área adyacente 40 e intensa activación en las áreas ejecutivas de la corteza frontal números 6, 8, 9, y 10 de Brodmann. También hubo activación del área 7 de Brodmann; área de asociación audio-visual; más marcada en el lado derecho de la paciente y de los controles normales estimulados. En las estructuras subcorticales también hubo una marcada activación en la paciente con alucinaciones en ambos núcleos lentiformes, el tálamo y los núcleos caudados, también más intensos en el hemisferio derecho, 5, 4.7 y 4.2 desviaciones Standard (S.D.) sobre la media a derecha y 5, 3.3 y 3 S.D. sobre la media en el izquierdo. Hallazgos similares se encontraron en los controles normales. Conclusiones. Después de estimular auditivamente con tonos puros en el oído izquierdo en voluntarias normales, se observa activación del área 39 de Brodmann, más...


Assuntos
Humanos , Adulto , Feminino , Pessoa de Meia-Idade , Alucinações , Audiometria de Tons Puros , Córtex Auditivo , Memória/fisiologia , Música , Percepção Auditiva/fisiologia , Tomografia Computadorizada de Emissão de Fóton Único , Estimulação Acústica , Lobo Temporal/fisiologia
12.
Artigo em Inglês | LILACS | ID: lil-339337

RESUMO

Purpose. To correlate axillary Technetium-99m-sestamibi uptake with the axillary histology in patients with proven breast cancer. Secondly, to correlate the breast scintimammography results with the tumor histology. Materials and methods. Fifty-one patients with operable breast cancer T1, T2 or T3 and N0 or N1 had a scintimammography before surgery. Images were interpreted directly from the computer screen by two specialists who did not have knowledge about clinical or radiological information concerning the patients. Surgical treatment included conservative surgery or mastectomy, both followed by axillary dissection for malignant tumors (45 patients) and only excision for benign lesions (6 patients). Statistical analysis correlated scintimammography and histologic results. Results. The sensitivity and specificity of Tc99m-sestamibi to assess histologic lymph node involvement in patients with operable breast cancer was 35 percent (95 percent CI:14-61 percent) and 57 percent (95 percent CI:37-75 percent) respectively. The positive predictive value was 33 percent (95 percent CI:13-58 percent) and the negative predictive value was 59 percent ( 95 percent CI: 38-77 percent). The sensitivity and specificity of Tc99-sestamibi to assess breast tumor malignancy was 97 percent (95 percent CI:88-99 percent) and 33 percent (95 percent CI: 4-77 percent) respectively, calculated in only six patients. The positive predictive value was 91 percent (95 percent CI: 80-97 percent) and the negative predictive value was 66 percent (95 percent CI:9-99 percent). Conclusion. Our findings regarding the preoperative axillary assessment with Tc99m-sestamibi do not support the use of this imaging modality for this purpose


Assuntos
Humanos , Feminino , Neoplasias da Mama , Metástase Linfática/patologia , Axila , Mamografia , Cintilografia , Tecnécio Tc 99m Sestamibi , Linfonodos/patologia
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