RESUMO
Background The COVID-19 pandemic is a significant global health crisis that poses a threat to a person's psychological well-being. A very large number of people got exposed to social network sites during this period which can be hazardous and cause psychological difficulties. There is no prior research or limited studies in this area during emergencies in Nepal. Objective To assess the mental health issues and examine their relationship with social media exposure in adults. Method A descriptive cross-sectional study was conducted by using a validated scale of Depression, Anxiety, and Stress (DAAS-21) and the Insomnia Severity Index (ISI) among 18 years above adult population. Data were collected through an online survey. Descriptive statistics was used to describe sociodemographic data. Binary logistic regression analysis were performed to examine the relationship between psychological problems and social media exposure. Result Out of 422 participants, the overall prevalence of depression, anxiety, stress, and insomnia among the study population were 32%, 28.4%, 24.5%, and 47% respectively. Additionally, 86.5% of individuals said they were frequently exposed to social media. Age, ethnicity, gender, past health problems, and health status were significantly associated with psychological problems. Further, social media exposure was associated with gender and marital status. There was no evidence of an association of psychological problems with social media exposure. Conclusion Depression, anxiety, stress and insomnia are common mental health problems found in the adult population during the time of the first wave of COVID-19 pandemic and highly affected were under 25 years age. Female and unmarried adults are using more social media.
Assuntos
COVID-19 , Distúrbios do Início e da Manutenção do Sono , Adulto , Humanos , Feminino , COVID-19/epidemiologia , Saúde Mental , Distúrbios do Início e da Manutenção do Sono/epidemiologia , Nepal/epidemiologia , Estudos Transversais , Pandemias , Exposição à Mídia , SARS-CoV-2 , Depressão/epidemiologia , Ansiedade/epidemiologia , Ansiedade/etiologiaRESUMO
OBJECTIVES: Inflammation and inflammatory conditions have been associated with pancreatic cancer risk and progression in a number of clinical, epidemiological, and animal model studies. The goal of the present study is to identify plasma markers of inflammation associated with survival of pancreatic cancer patients, and assess their joint contribution to patient outcome. METHODS: We measured circulating levels of four established markers of inflammation (C-reactive protein (CRP), interleukin-6 (IL-6), soluble tumor necrosis factor receptor type II (sTNF-RII), and macrophage inhibitory cytokine-1 (MIC-1)) in 446 patients enrolled in an ongoing prospective clinic-based study. Hazard ratios (HRs) and 95% confidence intervals (CI) for death were estimated using multivariate Cox proportional hazards models. RESULTS: Overall mortality was significantly increased in patients in the top quartile of CRP (HR = 2.52, 95% CI: 1.82-3.49), IL-6 (HR = 2.78, 95% CI: 2.03-3.81), sTNF-RII (HR = 2.00, 95% CI: 1.46-2.72), and MIC-1 (HR = 2.53, 95% CI: 1.83-3.50), compared to those in the bottom quartile (P-trend <0.0001 for all four comparisons). Furthermore, patients with higher circulating concentrations of all four cytokines had a median survival of 3.7 months; whereas, those with lower levels had a median survival of 19.2 months (HR = 4.55, 95% CI: 2.87-7.20, P-trend <0.0001). CONCLUSION: Individual elevated plasma inflammatory cytokines are associated with significant and dramatic reductions in pancreatic cancer patient survival. Furthermore, we observed an independent combined effect of those cytokines on patient survival, suggesting that multiple inflammatory pathways are likely involved in PDAC progression. Future research efforts to target the inflammatory state using combination strategies in pancreatic cancer patients are warranted.
Assuntos
Carcinoma Ductal Pancreático/sangue , Carcinoma Ductal Pancreático/mortalidade , Citocinas/sangue , Inflamação/sangue , Neoplasias Pancreáticas/sangue , Neoplasias Pancreáticas/mortalidade , Idoso , Biomarcadores/sangue , Progressão da Doença , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Fatores de RiscoRESUMO
BACKGROUND: Magnetic Resonance Imaging is an appropriate screening tool before therapeutic arthroscopy, making diagnostic arthroscopy unnecessary in most patients. This study aims to evaluate the MRI findings in knee injuries and diagnostic value of low Strength MRI for assessing Meniscal and cruciate ligament tear. METHODS: A cross sectional study was conducted on patients undergoing "Magnetic Resonance Imaging of the Knee" for injuries of the knee and excluded patients undergoing MRI for other causes, poor diagnostic quality MRI and post operative MRI. All patients were interviewed for mechanism of injury and followed up for arthroscopic findings. Statistical analysis was doe using IBM SPSS 20.0. RESULTS: A total of 81 MRIs was included in the study. Arthroscopic finding of only 32 patients could be followed up. Anterior cruciate ligament (ACL) tear was the most common internal ligament tear accounting for 34(42%) of cases followed by medial meniscus tear in 33(40.7%). Twisting 14( 42.4%)was the most common mechanism involved in medial meniscus tear while combined mechanism of injury was most common mechanism for ACL tear 16( 47.05%). The sensitivity of MRI for diagnosis of ACL tear and medial meniscus tear was 96.3% and 94.7% respectively. Specificity for ACL tear was however only 80% and that for medial meniscus tear was 100%. CONCLUSIONS: The diagnostic value of MRI for diagnosing internal derangement of knee was high even with a low Tesla (0.3 T) MRI thus emphasizing the role of MRI as a non-invasive alternative to diagnostic arthroscopy.