[Cytomorphological criteria of atypical hyperplasia and cancer of the endometrium based on data from a multivariate statistical analysis]. / Tsitomorfologicheskie kriterii atipicheskoi giperplazii i raka éndometriia po dannym mnogomernogo statisticheskogo analiza.

Multifactorial statistical analysis was used to identify differential diagnostic cytological features of glandular hyperplasia, atypical hyperplasia and well-differentiated adenocarcinoma of the endometrium. Twelve cytological features were identified for calculating linear discriminant function. The effectiveness of the diagnostic algorithm depends upon the diagnostic value of the sample and proficiency of the cytologist.

[The role of cytological studies in evaluating the severity of dysplasia during prophylactic gynecological examinations (cooperative study)]. / Znachenie tsitologicheskogo issledovaniia v otsenke tiazheloi displazii pri profilakticheskikh ginekologicheskikh osmotrakh (kooperirovannoe issledovanie).

Cytologic examination of scrapings from the uterine cervix was carried out in 498 patients in whom moderate or severe dysplasia of the squamous epithelium or suspicion for cancer were established in the course of gynecologic screening. The said pathology was diagnosed in 0.63% of screeneses. Cytologic follow-up of 57 cases of severe dysplasia established that, in patients over 40 years of age, it tended to progress to Ca in situ. This tendency was registered within 6-36 months and continued after a second biopsy. Severe dysplasia did not recur in the 20-40 year-old group. The extent of cervical biopsy (excision or conization) in severe dysplasia should be considered versus patients' age.

[Cytological characteristics of severe dysplasia, intraepithelial cancer and stage IA cancer of the cervix uteri based on multivariate analysis (joint study)]. / Tsitologicheskie priznaki tiazheloi displazii, vnutriépitelial'nogo raka i raka IA stadii sheiki matki po dannym mnogomernogo statisticheskogo analiza. (kooperirovannoe issledovanie).

The investigation was concerned with a computer statistical analysis of 40 cytological indexes of severe dysplasia, intraepithelial cancer and stage IA carcinoma of cervix uteri. It was found that, irrespective of stage, of major importance are such factors as atypia of cells and nuclei, cell division rate, keratinization involving the formation of specific structures, increasing atypia of cells accompanied by high-rate division and reduction in variety of cell functions.

[Organizational aspects of the work of a centralized cytological laboratory]. / Organizatsionnye aspekty raboty tsentralizovannoi tsitologicheskoi laboratorii.

An experience of organizing of activity of a centralized cytological laboratory is presented in the paper. It is based on an analysis of activity of leading cytological laboratories of the RSFSR. Certain issues of training of cytologists, laboratory assistants and technical staff on the basis of leading institutions of the country as well as problems of setting up control over reliability of cytological conclusions are discussed.

[The results of cooperative studies in oncology in the RSFSR]. / Nekotorye itogi kooperirovannykh issledovanii po onkologii v RSFSR.

The paper is concerned with the joint scientific studies conducted at the Institute and hospitals of the Russian Federative Republic in accordance with the Republic-sponsored complex program of research in neoplasms. The results of organization work obtained within the last 5 years, research and clinical data on some aspects of the problem are discussed. It is stressed that joint studies are of great importance for both speeding up the solution of research and practical problems and effective monitoring the integration of scientific achievements with practice to raise the standards of service offered by public health institutions. The results of studies on combined treatment of lung and breast cancer and diagnosis and therapy of cervical and endometrial carcinoma are evaluated.

[Organization of cooperative oncologic immunological research in the RSFSR]. / Organizatsiia kooperirovannykh onkoimmunologicheskikh issledovanii v RSFSR.

A number of medical establishments are conducting a joint study on Immunology of Tumors sponsored by CMEA. The study is carried out under the auspices of the P. A. Herzen Research Institute in the following directions: (1) Investigations in the diagnostic and prognostic value of immunologic tests in oncological clinic; (2) Establishment of basal immunological status of patients and its changes in relation to stages of cancer development; (3) Identification of immunological markers for tumors of different sites. This research is channeled into several programs. The success of the whole venture depends on active participation of all concerned. The results of the study will contribute to the clinical experience of application of immunological tests in examination of considerable groups of patients with tumors at different sites.

[Detection of threatened pathology and cancer of the cervix uteri during prophylactic examinations (based on the results of a cooperative study)]. / Vyiavlenie ugrozhaemoi patologii i raka sheiki matki pri profilakticheskikh osmotrakh (po rezul'tatam kooperirovannogo issledovaniia).

Preliminary results are reported on the coordinating studies, conducted by the five oncological institutions of the Russia Federation on elaborating cytological criteria of the cervical epithelium malignant transformation. The material under investigation was the smears taken at mass prophylactic examinations. A group of women (512) with high cancer risk pathology has been distinguished--/various degree of dysplasia, preinvasive cancer, cancer in stage Ia/. A special card of cytological signs (including 40 criteria) was worked out for a computer analysis to select the major signs of malignancy which might contribute to establishing the most precise morphological diagnosis.

[Clinico-morphological changes during treatment of endometrial cancer with progestins]. / Kliniko-morfologicheskie izmeneniia pri lechenii raka éndometriia progestinami.

The results of the complex clinico-morphological study of the effect of 17-a-hydroxyprogesterone-caproate are reported in 71 patients aged from 37 to 75. Stage I was noted in 17 patients, stage II--in 51, stage III--in 3. A total dosage was 5,0; 10,0; 20,0 and 30,0 for the course of treatment. Following the hormonal therapy all these patients were subjected to surgery. To study the hormonal pathomorphism specimens from the uterine cavity were assayed histologically and cytologically prior to and during the hormonal therapy, the removed specimen was examined after the operation. The clinico-morphological studies indicated that 17 GPC shows the antitumor effect in endometrial cancer, so the complete tumor regression seems to be possible. The antitumor effect is mostly pronounced at initial stages of the disease and with high-differentiated tumors. The data obtained may be used to solve the problem on the purposeful application of 17 GPC either in the complex of therapeutic measures or as a separate method of treatment.

[Clinico-cytological characteristics of primary invasive cervical cancer]. / Kliniko-tsitologicheskaia kharakteristika nachal'nogo invazivnogo raka sheiki matki.

Based on the material of the complex examination of 167 cervical cancer patients in stage Ia, the clinico-cytological features were studied comparatively. Extensive colposcopy and cytological assays of surface curetting specimens from the cervical canal and cervix mucosa were employed. In cervical cancer, stage Ia, cytological assay in 71.4% of cases is a reliable criterion in diagnosing the malignancy. In 51.7% of patients cytograms are similar to those of intraepithelial cancer, in 40.7%--smears correspond to the classical description of squamous cell cancer. The stromal reaction should be regarded as an indicator of a limited malignancy and as a manifestation of protective forces of the organism.