[Blood groups of the ABO system of chronic carriers of typhoid bacteria and typhoid patients in Uzbekistan]. / Gruppy krovi sistemy ABO u khronicheskikh nositelei briushnotifoznykh bakterii i bol'nykh briushnymtifom v Uzbekistane

Blood groups of the ABO system were studied in 186 chronic carriers of typhoid bacilli and in 392 patients with typhoid fever from various districts of the Uzbek SSR. In comparison with control (healthy persons), carriers displayed a higher percentage of persons with A (II) blood group (50.88 and 42.64 against 37.51 and 32.13 in control) and a lesser percentage of persons with the O (I) blood group (21.05 and 22.48 against 32.93 and 32.07 in control). These data demonstrated that predisposition of persons with the A (II) blood group to chronic typhoid carrier state was characteristic of the Asian part of the country. In comparison with control, there were significantly less persons with the O (I) blood group and more with the AB (IV) blood group. Possible correlative mechanisms between the blood group and the typhoid infection and the development of chronic typhoid carrier state is discussed.

Participation of the thymus in the mechanism of bacterial discharge in carriers of typhoid bacteria. / Ob uchastii timusa v mekhanizme bakteriovydeleniia u nositelei briushnotifoznykh bakterii

Typhoid carrier state was reproduced in 54 rabbits by the injection of typhoid bacilli into the bone marrow of the femoral bone. The animals were divided into 3 groups. Those in the 1st and 2nd group were hydrocortisone and ATC before the infection, respectively, whereas the 3rd group served as control. The data obtained pointed to the great incidence of prolonged persistence of typhoid bacilli in the bone marrow. A much greater vital disharge of the causative agent with the feces was noted in the animals which before the infection were given hydrocortisone and ATC preparations depressing the functional activity of the thymus. In the second experimental series it was shown that ATC administration to rabbits on the 85th day after their intraosseous infection with typhoid bacilli promoted vital discharge of the causative agent with the feces. Problem of participation of the thymus in the mechanism of bacterial discharge in the carriers of typhoid bacilli are discussed.