RESUMO
The intraoperative management of a patent jugular bulb presents a formidable challenge during the treatment of lateral skull base lesions. Whether to preserve, partially occlude, or completely sacrifice this critical structure is a decision best made following a multifactorial analysis of preoperative clinicoradiographic data, tumor histopathology, and intraoperative findings. Twenty-six patients with tumors requiring dissection near a patent jugular bulb were reviewed. Ten patients had superior neck tumors, nine had primary temporal bone lesions, and seven presented with recurrent parotid malignancies. The most common clinical manifestations were headache and vocal cord paralysis and the most significant radiographic finding was the presence of a mass at the styloid base. Jugular bulb patency was preserved in six patients, partially maintained in seven, and was sacrificed in 13 individuals. This article focuses on the clinicoradiographic findings in patients with neoplastic jugular foramen encroachment, but preserved jugular blood flow. Surgical technique will be detailed through selected case presentations and the management of lower cranial nerve injuries will be reviewed.
RESUMO
The great majority of cases of sinusitis are uncomplicated. These infections, however, can result in significant morbidity and often mortality. One must be vigilant in detecting orbital or intracranial spread and iatrogenic injury from surgery because manifestations of these complications can be protean. A good knowledge of the anatomy, the clinical signs, and some key laboratory data is crucial to successful treatment of this challenging disease.
Assuntos
Sinusite/complicações , Abscesso Encefálico/etiologia , Abscesso Encefálico/cirurgia , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Mucocele/diagnóstico , Mucocele/diagnóstico por imagem , Mucocele/etiologia , Descongestionantes Nasais/uso terapêutico , Osteomielite/etiologia , Osteomielite/microbiologia , Osteomielite/cirurgia , Complicações Pós-Operatórias , Radiografia , Sinusite/diagnóstico , Sinusite/tratamento farmacológico , Staphylococcus aureus/isolamento & purificaçãoRESUMO
The retrosigmoid approach is utilized in a variety of cerebellopontine angle and internal auditory canal procedures. Drill curettage of the posterior internal auditory canal enhances lateral exposure, however, this step may also increase the patient's risk for postoperative cerebrospinal fluid (CSF) otorrhea. Obliteration of perilabyrinthine air cells is technically difficult and muscle graft displacement frequently occurs. A technique for posterior petrous dural flap stabilization of a temporalis muscle plug has proved successful in decreasing the risk of postoperative CSF fistula following retrosigmoid surgery. Temporal bone air-cell anatomy, as it relates to retrosigmoid, posterior internal auditory canal surgery is reviewed. Our technique for internal auditory canal closure, with bone wax, bone paté, muscle grafts, and petrous ridge dural flaps is outlined.
Assuntos
Ângulo Cerebelopontino/cirurgia , Colo Sigmoide/cirurgia , Meato Acústico Externo/fisiopatologia , Orelha Interna/fisiopatologia , Otorreia de Líquido Cefalorraquidiano/complicações , Meato Acústico Externo/cirurgia , Orelha Interna/cirurgia , Feminino , Humanos , Masculino , Complicações Pós-Operatórias , Retalhos CirúrgicosRESUMO
Intention-to-treat analysis is an important aspect of randomized controlled trials of health care interventions. The concept is now widely accepted in theory, but not always implemented in practice. Failure to analyse by intention-to-treat can give misleading and indeed life-threatening interpretations. In some studies, a case is put for estimating the effect that would have been observed if all patients had received the allocated treatment. Situations where this is valid are rare, but an example is given of such an exceptional study. The relevance of the intention-to-treat concept is not always taken into account in qualitative research. Interviews with new mothers who delivered their babies at home in a hypothetical controlled trial of home versus hospital confinement would provide fascinating accounts of the pleasure of successful delivery at home. But by definition the interviews would exclude the hazard and drama of necessary transfers to hospital due to complications in late pregnancy and early labour. The intention-to-treat approach would avoid this bias.
Assuntos
Ensaios Clínicos Controlados Aleatórios como Assunto/métodos , Terapêutica , Estudos de Coortes , Interpretação Estatística de Dados , Estudos de Avaliação como Assunto , Humanos , Cooperação do Paciente , Distribuição Aleatória , Projetos de PesquisaRESUMO
This paper reviews the issues which arose in the design of a randomized controlled trial of three experimental National Health Service nursing homes. Problems associated with the implementation of the trial included ethical issues, choice of sample size and recruitment of subjects to the trial, choice and validity of measures of outcome, evaluation of outcomes and replicability of findings. The distinction between explanatory and pragmatic trials is shown to overcome some of these problems.
Assuntos
Instituição de Longa Permanência para Idosos/organização & administração , Casas de Saúde/organização & administração , Medicina Estatal , Idoso , Estudos de Avaliação como Assunto , Humanos , Reino UnidoRESUMO
This paper reviews the implementation of a pragmatic multicentred randomized controlled trial in the evaluation of three experimental nursing homes. The organization of services for the care of elderly people varied between the three centres, and each used different criteria for selecting subjects for the trial and different methods of seeking informed consent. Data presented show that in each centre two truly randomized samples have been selected. However, differences between centres, in the characteristics of selected subjects, reflect the implementation of the trials in each of the centres. These findings emphasize the importance of good collaboration between health professionals providing the service, an independent research team, and the establishment of rigorous criteria for inclusion and exclusion of subjects at the outset.
Assuntos
Instituição de Longa Permanência para Idosos/organização & administração , Casas de Saúde/organização & administração , Medicina Estatal , Idoso , Ensaios Clínicos como Assunto , Estudos de Avaliação como Assunto , Humanos , Estudos Multicêntricos como Assunto , Reino UnidoRESUMO
Parathyroidectomy is usually followed by a decrease in serum calcium, a lessening of symptoms, and a normocalcemic state that continues for years. Evaluation of parathyroid gland function after parathyroidectomy over a protracted period showed a continued hypersecretory state in many normocalcemic patients and is reported here for the first time. Patients identified with parathyroid hyperplasia (more than one gland excised) and patients who later developed mild renal failure were excluded. Seventy-seven patients undergoing parathyroidectomy with only one enlarged gland removed and the other normal-sized glands viewed or examined by biopsy were followed up from 5 to 16 years. Two patients developed recurrent hypercalcemia at 4 and 9 years after surgery. Seventy-five patients are considered "cured" and have normal serum calcium values. However, 28 (37%) of these normocalcemic patients have persistent elevations of parathyroid hormone. This increased parathyroid gland function suggests a continuing stimulation of the remaining glands. The rarity of clinical recurrence may be related to effective adaptations that prevent overt hypercalcemia. Many parathyroid adenomas appear to represent nonneoplastic disease.
Assuntos
Hiperparatireoidismo/cirurgia , Glândulas Paratireoides/metabolismo , Cálcio/sangue , Seguimentos , Humanos , Hiperparatireoidismo/sangue , Hiperparatireoidismo/metabolismo , Glândulas Paratireoides/cirurgia , Hormônio Paratireóideo/sangue , Radioimunoensaio , RecidivaRESUMO
Thirty-four patients with atrial fibrillation complicating suspected acute myocardial infarction were randomised to treatment with intravenous amiodarone (n = 18) or intravenous digoxin (n = 16). After 24 h, similar proportions of patients in each group had reverted to sinus rhythm. However, there was a tendency towards earlier reversion with amiodarone. At 4 h, 72% of the amiodarone group had reverted to sinus rhythm, compared with 31% of the digoxin group (p less than 0.1). This tendency was more marked in patients with definite infarction (at 4 h, amiodarone 75% reversion, digoxin 10% reversion). Neither drug had a significant effect on blood pressure. Atrial fibrillation may cause serious haemodynamic deterioration in acute myocardial infarction. In comparison with digoxin, amiodarone offers more rapid control of the ventricular response rate and may, in addition, restore sinus rhythm more rapidly.
Assuntos
Amiodarona/uso terapêutico , Fibrilação Atrial/tratamento farmacológico , Benzofuranos/uso terapêutico , Digoxina/uso terapêutico , Infarto do Miocárdio/complicações , Idoso , Fibrilação Atrial/complicações , Pressão Sanguínea/efeitos dos fármacos , Ensaios Clínicos como Assunto , Eletrocardiografia , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Pessoa de Meia-Idade , Distribuição AleatóriaRESUMO
We compared the social, professional, and occupational characteristics of nurses employed by area health authorities and nurses employed by general practitioners by interviewing random samples of 153 nurses in 113 practices situated in four rural and five urban area health authorities in England. The two kinds of nurse were similar in most professional respects but differed in their social characteristics, career patterns, and terms and conditions of employment. They also differed in the singleness of their commitment and the hours they worked in the study practices.
Assuntos
Medicina de Família e Comunidade , Recursos Humanos de Enfermagem , Avaliação Educacional , Emprego , Inglaterra , Humanos , Recursos Humanos de Enfermagem/educação , Classe Social , Recursos HumanosRESUMO
We compared the nursing and medical activities and the opinions of nurses employed by area health authorities and nurses employed by general practitioners by interviewing a random sample of 153 nurses in 113 practices, situated in four rural and five urban area health authorities in England. The availability of a treatment room profoundly affected the work of both kinds of nurse and there were differences between them in the balance between ;caring' and ;technical' activities which may be largely attributed to the circumstances of their employment. However, their occupational histories and choices of employer appear to reflect both differences in their training and differences in their values about career and marriage.
Assuntos
Atitude do Pessoal de Saúde , Medicina de Família e Comunidade , Recursos Humanos de Enfermagem/psicologia , Humanos , Trabalho , Recursos HumanosRESUMO
Cycloalliin is a natural constituent of onion, sulphur-containing but odourless. It was synthesised for this randomised double-blind study; its effect on fibribolytic activity and platelet aggregability was tested in venous blood from 18 male volunteers. It increased the former to a highly significant degree but had no effect on the latter. It was well tolerated and harmless in the single oral dosage used.
Assuntos
Fibrinólise/efeitos dos fármacos , Fibrinolíticos/farmacologia , Ácidos Pipecólicos/farmacologia , Adulto , Idoso , Ensaios Clínicos como Assunto , Óxidos Heterocíclicos/farmacologia , Humanos , Masculino , Pessoa de Meia-Idade , Agregação Plaquetária/efeitos dos fármacosRESUMO
Patients with inguinal hernia or haemorrhoids were randomly allocated to an experimental group expected to stay in hospital for only eight hours after surgery or a control group scheduled for discharge on the fifth or sixth day. There was no difference in clinical outcome between the two groups of hernia patients. However, complications were twice as common in haemorrhoid day-patients as in long-stay haemorhoid patients. The standard postoperative regimen for haemorrhoids has since been changed and the change has been accompanied by a fall in the complication-rate. Day-case surgery appears to have similar social effects on the patient and his family as traditional hospital care. There was no significant difference in either the additional expenditure incurred or patients' perceptions of the disruption associated with their operation and convalescence. In the hospital under study, day-case surgery was saving between 20 pounds and 29 pounds per patient. However, this conclusion should not be extrapolated to the N.H.S. as a whole without taking into account the use to which the resources released by day-case surgery will be put.
Assuntos
Hospital Dia , Hemorroidas/cirurgia , Hérnia Inguinal/cirurgia , Adolescente , Adulto , Idoso , Agendamento de Consultas , Análise Custo-Benefício , Inglaterra , Estudos de Avaliação como Assunto , Feminino , Humanos , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Cuidados Pós-Operatórios , Complicações Pós-Operatórias , Encaminhamento e Consulta , Fatores Socioeconômicos , Fatores de TempoRESUMO
Two hundred and fifty men admitted to a thoracic surgical centre and matched controls were questioned in detail about their occupations after leaving school and their smoking habits. Of 201 men with confirmed bronchial carcinoma 58 gave a history of occupational exposure to asbestos, whereas only 29 out of 201 men matched for age and residential area who were admitted with other diseases gave such a history. This difference was statistically highly significant. The usual association of bronchial carcinoma with heavy smoking was observed, but asbestos exposure increased the risk of carcinoma whatever the level of smoking. These results are consistent with the hypothesis that asbestos exposure and the level of smoking act independently in causing bronchial carcinoma. The patients with carcinoma who had been exposed to asbestos presented on average three years earlier than those who had not been exposed. Asbestos regulations have eliminated the risk of exposure to workers in scheduled industries, so asbestos-induced diseases will probably be increasingly found among the many workers who have had incidental exposure to asbestos. It is therefore important to take a full occupational history.
Assuntos
Amianto/efeitos adversos , Neoplasias Brônquicas/induzido quimicamente , Doenças Profissionais/etiologia , Adenocarcinoma/induzido quimicamente , Idoso , Neoplasias Brônquicas/epidemiologia , Carcinoma de Células Escamosas/induzido quimicamente , Inglaterra , Exposição Ambiental , Humanos , Masculino , Pessoa de Meia-Idade , Fumar/complicaçõesRESUMO
A double-blind crossover trial comparing lorazepam at two dosage levels with amylobarbitone supported previous reports of the effective anxiolytic action of the drug. Evaluation of the patients' responses during each week of treatment was based on a physician's weekly rating and on daily self-rating by patients. The results were analyzed by sequential and nonsequential analyses. The main side effect of the drug was drowsiness, which occurred to a clinically significant degree among the high-dose group of patients. The authors emphasize the value of two dosage trials, particularly in devising subsequent flexible individual treatment regimens.
Assuntos
Amobarbital/uso terapêutico , Ansiolíticos/uso terapêutico , Ansiedade/tratamento farmacológico , Lorazepam/uso terapêutico , Adolescente , Adulto , Idoso , Amobarbital/efeitos adversos , Ensaios Clínicos como Assunto , Avaliação de Medicamentos , Feminino , Humanos , Lorazepam/administração & dosagem , Lorazepam/efeitos adversos , Masculino , Pessoa de Meia-Idade , Náusea/induzido quimicamente , Inconsciência/induzido quimicamenteRESUMO
In 1974 we sent questionnaires on attachment and employment of nurses to 9214 general practices in England. There were 7863 replies (85%), of which 551 were excluded from the study. A total of 2654 nurses were directly employed by 24% (1774) of the practices, and 68% (4972) had attached nurses. Practices in health centres were larger and had greater nursing resources than those in other premises. We suggest that practices may employ nurses to compensate for ineffective nursing attachments, and we conclude that general-practice-employed nurses are becoming "professionalised".
Assuntos
Medicina de Família e Comunidade , Enfermagem Ambulatorial , Inglaterra , Instalações de Saúde , Atenção Primária à Saúde , Inquéritos e Questionários , Recursos HumanosRESUMO
The vascular hypothesis of the cause of muscular dystrophy suggests that ischemia is responsible for the muscle fiber necrosis. A xenon 133 clearance study of muscle blood flow in Duchenne and other muscular dystrophies showed no obvious difference between the response to exercise and arterial occlusion compared with control subjects. Radioautographic study of distribution of 4-125l-antipyrine in skeletal muscle of mice with muscular dystrophy showed no abnormal areas of ischemia. A statistical examination was also made of the grouping of damaged fibers, one of the observations on which the vascular hypothesis was based. Only 0.9% of fibers undergoing phagocytosis occurred in groups of four or more fibers in greater frequency than would have been expected by chance, and 70% of such fibers were isolated. These studies argue strongly against the vascular hypothesis of the cause of muscular dystrophy.
Assuntos
Músculos/irrigação sanguínea , Distrofias Musculares/etiologia , Adulto , Animais , Antipirina , Autorradiografia , Circulação Sanguínea , Criança , Humanos , Radioisótopos do Iodo , Isquemia/fisiopatologia , Perna (Membro) , Masculino , Camundongos , Camundongos Endogâmicos , Pessoa de Meia-Idade , Distrofias Musculares/fisiopatologia , Miofibrilas , Necrose , Esforço Físico , Fluxo Sanguíneo Regional , Radioisótopos de XenônioRESUMO
In a multicentre trial 456 selected patients with low back pain were randomly allocated to one of four treatments-manipulation, definitive physiotherapy, corset, or analgesic tablets. Patients were reassessed clinically after three weeks' treatment and again after a further three weeks. Questionnaires were used to find out the patients' condition three months and one year after admission to the trial. There were never any important differences among the four groups of patients. A few patients responded well and quickly to manipulation, but there was no way of identifying such patients in advance. The response to a corset was slow, but the long-tern effects were at least as good as those of the other treatments. Patients treated only with analgesics fared marginally worse than those on the other three treatments. There is no strong reason, however, for recommending manipulation over physiotherapy or corset.