Site-specific agronomic information and technology adoption: A field experiment from Ethiopia.

Smallholder farmers in Africa typically only have access to blanket fertilizer recommendations which are defined over very broad areas and may not be optimal for local production conditions. The response to such recommendations has generally been poor. Using a randomized control trial in Ethiopia, we explore whether targeted extension advice leads farmers to align fertilizer usage to the recommended levels and whether this impacts productivity. We also consider whether coupling the targeted information with agricultural insurance encourages fertilizer investment. Results show that targeted recommendations closed the gap between the amount of fertilizer used and the recommended amounts and this in turn increased productivity and profits. We found no differential effect of the targeted recommendation when coupled with agricultural insurance, suggesting that the risk of crop failure is not a binding constraint to fertilizer adoption in this context, or that farmers do not consider agricultural insurance a useful risk-mitigating mechanism.

Opportunities to replace the use of animals in sepsis research. The report and recommendations of a Focus on Alternatives workshop.

Sepsis and multiple organ failure are common causes of death in patients admitted to intensive care units. The incidence of sepsis and associated mortalities has been steadily increasing over the past 20 years. Sepsis is a complex inflammatory condition, the precise causes of which are still poorly understood. Animal models of sepsis have the potential to cause substantial suffering, and many of them have been poorly representative of the human syndrome. However, a number of non-animal approaches, including in vitro, in silico and clinical studies, show promise for addressing this situation. This report is based on discussions held at an expert workshop convened by Focus on Alternatives and held in 2004 at the Wellcome Trust, London. It provides an overview of some non-animal approaches to sepsis research, including their strengths and weaknesses, and argues that they should be prioritised for further development.

Report of a meeting to discuss a National Centre for the Replacement of Animals in Experiments.

Following the publication of their joint proposal for a National Centre for the Replacement of Animals in Experiments in 2002, the Dr Hadwen Trust and the Lord Dowding Fund organised a meeting, held on 18 November 2003 at Portcullis House, Westminster, in London, in order to discuss the concept further. A one-page summary of their proposal is attached as an appendix, and full copies are available from the Lord Dowding Fund and the Dr Hadwen Trust. The meeting aimed to discuss the need to stimulate and promote research to replace animal experiments by means of a National Centre (a coordinating body), and how this should be established and funded. Participants, numbering about 80 in total, included politicians (national and European), government officials, scientists, funding bodies and animal welfare representatives. This report is a summary of the issues raised by speakers and other participants at the meeting.