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1.
Med J Malaysia ; 74(6): 540-542, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31929483

RESUMO

Distal oesophageal spasm is a rare condition that affects the motility of the oesophagus. It can be diagnosed by highresolution oesophageal manometry and the diagnosis is supported by other modalities such as barium swallow and esophagogastroduodenoscopy examinations. Treatment options include pharmacological therapy, endoscopy and surgical interventions. We described a case of distal oesophageal spasm in an elderly patient who presented with chronic dyspepsia.


Assuntos
Espasmo Esofágico Difuso/diagnóstico , Esôfago/fisiopatologia , Refluxo Gastroesofágico/diagnóstico , Azia/diagnóstico , Idoso , Diagnóstico Diferencial , Espasmo Esofágico Difuso/complicações , Espasmo Esofágico Difuso/fisiopatologia , Humanos , Masculino , Manometria , Pressão
2.
Med J Malaysia ; 73(1): 60-62, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-29531208

RESUMO

Neuroendocrine neoplasm is an epithelial neoplasm with predominant neuroendocrine differentiation that can arise from many organs in the body. We reported a rare case of gastric neuroendocrine carcinoma which accounts for less than 1% of all gastric tumours that is associated with poor prognosis. The recognition of this rare tumour in early stage is challenging and high suspicious into it might bring to early detection and so forth might improve the prognostication.


Assuntos
Ascite/etiologia , Carcinoma Neuroendócrino/diagnóstico , Neoplasias Gástricas/diagnóstico , Ascite/diagnóstico por imagem , Ascite/patologia , Carcinoma Neuroendócrino/complicações , Carcinoma Neuroendócrino/diagnóstico por imagem , Carcinoma Neuroendócrino/patologia , Endossonografia , Humanos , Masculino , Pessoa de Meia-Idade , Estômago/diagnóstico por imagem , Estômago/patologia , Neoplasias Gástricas/complicações , Neoplasias Gástricas/diagnóstico por imagem , Tomografia Computadorizada por Raios X
3.
Med J Malaysia ; 73(6): 436-438, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30647226

RESUMO

Hepatic haemangioma is a solitary liver lesion and prevalent among the female patients. We report a case of diffuse hepatic haemangiomatosis in a 62-year-old man, who was referred for an incidental finding of multiple liver nodules. History and physical examinations were unremarkable. Computed tomography and magnetic resonance imaging of the liver were performed and showed multiple haemangiomatosis. In view of the rarity of this condition in men, a liver biopsy was done and confirmed haemangiomas. Available published literature on diffuse hepatic haemangiomatosis was reviewed.


Assuntos
Hemangioma/diagnóstico , Neoplasias Hepáticas/diagnóstico , Biópsia , Hemangioma/diagnóstico por imagem , Hemangioma/patologia , Humanos , Fígado/diagnóstico por imagem , Fígado/patologia , Neoplasias Hepáticas/diagnóstico por imagem , Neoplasias Hepáticas/patologia , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X
5.
Med J Malaysia ; 72(1): 77-79, 2017 02.
Artigo em Inglês | MEDLINE | ID: mdl-28255151

RESUMO

Percutaneous Endoscopic Gastrostomy (PEG) tubes were often offered to patients requiring long term enteral feeding. Even though the procedure is relatively safe, it is associated with various complications such as peritonitis or even death.1 We presented a case of a 54-year-old gentleman with underlying ischemic stroke and pus discharges from a recently inserted PEG tube. Computed Topography (CT) scan confirmed abdominal wall necrotising fasciitis complicated with hyperosmolar hyperglycaemia state (HHS) and later succumbed after 48 hours of admission. Our case illustrated the rare complication related to the insertion of PEG tube; abdominal wall necrotising fasciitis that was associated with mortality.


Assuntos
Parede Abdominal , Fasciite Necrosante/etiologia , Gastroscopia/efeitos adversos , Gastrostomia/efeitos adversos , Parede Abdominal/microbiologia , Parede Abdominal/patologia , Parede Abdominal/cirurgia , Fasciite Necrosante/diagnóstico por imagem , Fasciite Necrosante/patologia , Evolução Fatal , Gastroscopia/métodos , Gastrostomia/métodos , Humanos , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X
6.
Asian Pac J Cancer Prev ; 17(8): 4037-41, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27644658

RESUMO

BACKGROUND: Hepatocellular carcinoma (HCC) is a common cancer that is frequently diagnosed at an advanced stage. Transarterial chemoembolisation (TACE) is an effective palliative treatment for patients who are not eligible for curative treatment. The two main methods for performing TACE are conventional (c-TACE) or with drug eluting beads (DEB-TACE). We sought to compare survival rates and tumour response between patients undergoing c-TACE and DEB-TACE at our centre. MATERIALS AND METHODS: A retrospective cohort study of patients undergoing either treatment was carried out from January 2009 to December 2014. Tumour response to the procedures was evaluated according to the modified Response Evaluation Criteria in Solid Tumors (mRECIST). Kaplan-Meier analysis was used to assess and compare the overall survival in the two groups. RESULTS: A total of 79 patients were analysed (34 had c-TACE, 45 had DEB-TACE) with a median follow-up of 11.8 months. A total of 20 patients in the c-TACE group (80%) and 12 patients in the DEB-TACE group (44%) died during the follow up period. The median survival durations in the c-TACE and DEB-TACE groups were 4.9 ± 3.2 months and 8.3 ± 2.0 months respectively (p=0.008). There was no statistically significant difference noted among the two groups with respect to mRECIST criteria. CONCLUSIONS: DEB-TACE demonstrated a significant improvement in overall survival rates for patients with unresectable HCC when compared to c-TACE. It is a safe and promising approach and should potentially be considered as a standard of care in the management of unresectable HCC.


Assuntos
Carcinoma Hepatocelular/terapia , Doxorrubicina/administração & dosagem , Neoplasias Hepáticas/terapia , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma Hepatocelular/patologia , Quimioembolização Terapêutica/métodos , Feminino , Humanos , Estimativa de Kaplan-Meier , Neoplasias Hepáticas/patologia , Malásia , Masculino , Pessoa de Meia-Idade , Critérios de Avaliação de Resposta em Tumores Sólidos , Estudos Retrospectivos , Taxa de Sobrevida , Centros de Atenção Terciária , Resultado do Tratamento , Adulto Jovem
8.
BMJ Case Rep ; 20102010 Sep 29.
Artigo em Inglês | MEDLINE | ID: mdl-22778377

RESUMO

Rituximab is a B-cell-depleting monoclonal anti-CD20 antibody. It is widely used in haematology and rheumatology. However, usage of rituximab in immunosupressed patient has been associated with various opportunistic infections. The authors reported a case of refractory rheumatoid arthritis treated with rituximab, which later presented with non-resolving pneumonia with pulmonary nodule. Percutaneous computer tomogram guided lung biopsy was arranged to confirm the suspicion of tuberculosis, but did not yield conclusive results. Later, she presented left-chest abscess and underwent incision and drainage. The pus culture and sensitivity confirmed pulmonary nocardiosis with chest wall dissemination. She was treated with 2-week course of trimethoprim sulfamethoxazole and responded. The authors also reviewed published cases of nocardiosis post-rituximab.


Assuntos
Anticorpos Monoclonais Murinos/uso terapêutico , Antirreumáticos/uso terapêutico , Artrite Reumatoide/complicações , Nocardiose/etiologia , Pneumonia Bacteriana/etiologia , Antibacterianos/uso terapêutico , Anticorpos Monoclonais Murinos/efeitos adversos , Antirreumáticos/efeitos adversos , Artrite Reumatoide/tratamento farmacológico , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-Idade , Nocardiose/diagnóstico , Nocardiose/tratamento farmacológico , Pneumonia Bacteriana/diagnóstico , Pneumonia Bacteriana/tratamento farmacológico , Rituximab , Combinação Trimetoprima e Sulfametoxazol/uso terapêutico
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