RESUMO
Introduction: The recognition of religion's significance in mental health has led to several scientific advances in diagnosis or treatment. In contrast, Vietnam is a multi-religious Southeast Asian country with a large number of believers, but there is almost no research addressing the impact of religiosity among Vietnamese believers on mental health concerns such as depression, happiness, and gratitude. Participants and Methods: Our cross-sectional study was focused on Vietnamese believers (N = 374), surveyed directly at different religious facilities in Vietnam. The present study was evaluated utilizing the partial least squares-structural equation modeling (PLS-SEM) methodology. Results: The primary findings of the study indicate that (i) age was found to positively moderate the association between intrinsic religiosity and gratitude (ß = 0.191, 95% CI [0.116, 0.277], p < 0.001); (ii) Intrinsic religiosity has a positive influence on depression-happiness scale (ß = 0.276, 95% CI [0.168, 0.373], p < 0.001) and gratitude (ß = 0.337, 95% CI [0.205, 0.466], p < 0.001); Moreover, (iii) gratitude has a positive influence on depression-happiness scale (ß = 0.381, 95% CI [0.280, 0.491], p < 0.001); Finally, (iv) the study revealed that gratitude mediates the relationship between intrinsic religiosity and depression-happiness scale (ß = 0.128, 95% CI [0.071, 0.197], p < 0.001). Discussion: The findings of this study suggest that gratitude could potentially play a significant role in comprehending the association between religiosity and the levels of depression and happiness experienced by religious individuals in Vietnam.
RESUMO
INTRODUCTION: Patients with positive tauopathy but negative Aß42 (A-T+) in the cerebrospinal fluid (CSF) represent a diagnostic challenge. The Aß42/40 ratio supersedes Aß42 and reintegrates "false" A-T+ patients into the Alzheimer's disease spectrum. However, the biomarker and clinical characteristics of "true" and "false" A-T+ patients remain elusive. METHODS: Among the 509 T+N+ patients extracted from the databases of three memory clinics, we analyzed T+N+ patients with normal Aß42 and compared "false" A-T+ with abnormal Aß42/40 ratio and "true" A-T+ patients with normal Aß42/40 ratio, before CSF analysis and at follow-up. RESULTS: 24.9% of T+N+ patients had normal Aß42 levels. Among them, 42.7% were "true" A-T+. "True" A-T+ had lower CSF tauP181 than "false" A-T+ patients. 48.0% of "true" A-T+ patients were diagnosed with frontotemporal lobar degeneration before CSF analysis and 64.0% at follow-up, as compared with 6% in the "false" A-T+ group (P < .0001). DISCUSSION: Frontotemporal lobar degeneration is probably the main cause of "true" A-T+ profiles.
