RESUMO
A new sesterterpene, erinacine S, and one cyathane diterpene xyloside, erinacine A, were isolated from the ethanol extract of the mycelia of Hericium erinaceus. Their structures were elucidated by spectroscopic and X-ray analysis. A 30-day oral course of erinacines A and S attenuated Aß plaque burden in the brains of 5-month-old female APP/PS1 transgenic mice. Moreover, erinacines A and S significantly increased the level of insulin-degrading enzyme in cerebral cortex.
Assuntos
Basidiomycota/química , Sesterterpenos/isolamento & purificação , Animais , Encéfalo/enzimologia , Diterpenos/química , Diterpenos/isolamento & purificação , Feminino , Insulisina/metabolismo , Camundongos , Camundongos Transgênicos , Estrutura Molecular , Micélio/química , Sesterterpenos/química , TaiwanRESUMO
Three new sesquiterpene aryl esters and eight known compounds were isolated from the EtOH extract of the mycelium of Armillaria mellea. The structures of new compounds were established by analysis of their spectroscopic data. Some of the isolates showed cytotoxicity to a variety of cancer cell lines, including MCF-7, H460, HT-29, and CEM.
Assuntos
Antineoplásicos/farmacologia , Armillaria/química , Micélio/química , Sesquiterpenos/farmacologia , Antineoplásicos/química , Antineoplásicos/isolamento & purificação , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Doxorrubicina/farmacologia , Ésteres , Etanol/química , Células HT29 , Humanos , Células MCF-7 , Estrutura Molecular , Sesquiterpenos/química , Sesquiterpenos/isolamento & purificação , Extração em Fase Sólida , Solventes/químicaRESUMO
Four new apigenin derivatives, 7-de-O-methylaciculatin, 8-C-ß-D-boivinopyranosylapigenin, aciculatinone, and 4'-O-glucosylaciculatin, along with eight known compounds, apigenin-8-carbaldehyde, kaempferol, tricin, taxifolin, 6,7,4'-trihydroxyflavone, trans-oxyresveratrol, aciculatin, and luteolin-7-sulfate, were isolated from an ethanolic extract of Chrysopogon aciculatis. Their chemical structures were elucidated by spectroscopic methods. Among the known compounds, the natural occurrence of apigenin-8-carbaldehyde and luteolin-7-sulfate is demonstrated for the first time. Some of the isolates were evaluated for cytotoxic activity against human cancer cell lines including MCF-7, H460, HT-29, and CEM.
Assuntos
Antineoplásicos Fitogênicos/isolamento & purificação , Antineoplásicos Fitogênicos/farmacologia , Apigenina/isolamento & purificação , Apigenina/farmacologia , Poaceae/química , Antineoplásicos Fitogênicos/química , Apigenina/química , Ensaios de Seleção de Medicamentos Antitumorais , Feminino , Flavonoides/química , Flavonoides/isolamento & purificação , Células HT29 , Humanos , Quempferóis/química , Quempferóis/isolamento & purificação , Estrutura Molecular , TaiwanRESUMO
Three new compounds, magnolianone (1), erythro-honokitriol (2), and threo-honokitriol (3), together with 14 known compounds, magnaldehyde (4), magnatriol B (5), randaiol (6), obovatol (7), magnolignan B (8a and 8b), magnolol, honokiol (9), p-hydroxylbenzaldehyde, coniferaldehyde, coniferol alcohol, syringaldehyde, syringaresinol, and acteoside, were isolated from the MeOH-soluble part of a water extract of the stem bark of Magnolia officinalis. Among these compounds, 2-8b were studied for anti-inflammatory and antioxidative activities. Compound 7 displayed more potent antioxidative potential than 9. Compounds 4-7 effectively inhibited LPS-induced NO production, whereas 5 and 6 were more potent than 9.
Assuntos
Anti-Inflamatórios não Esteroides/isolamento & purificação , Antioxidantes/isolamento & purificação , Compostos de Bifenilo/isolamento & purificação , Cicloexanonas/isolamento & purificação , Magnolia/química , Plantas Medicinais/química , Animais , Anti-Inflamatórios não Esteroides/química , Anti-Inflamatórios não Esteroides/farmacologia , Antioxidantes/química , Antioxidantes/farmacologia , Compostos de Bifenilo/química , Compostos de Bifenilo/farmacologia , Cicloexanonas/química , Cicloexanonas/farmacologia , Lignanas/farmacologia , Lipopolissacarídeos/farmacologia , Camundongos , Microglia/efeitos dos fármacos , Estrutura Molecular , Óxido Nítrico/antagonistas & inibidores , Óxido Nítrico/metabolismo , Picratos/farmacologia , Casca de Planta/química , TaiwanRESUMO
Two new anthraquinones, 1,6-dihydroxy-5-methoxy-2-methoxymethylanthraquinone (1) and 1,5,7-trihydroxy-6-methoxy-2-methoxymethylanthraquinone (2), and one new lignan isoamericanoic acid A (3) were isolated from the fruits of Morinda citrifolia along with 11 known compounds scopoletin, luteolin, americanin A, americanin D, 3,3'-bisdemethylpinoresinol, p-cresol, p-hydroxybenzoic acid, p-hydroxybenzaldehyde, 4-hydroxy-3-methoxybenzaldehyde, 4-hydroxy-3-methoxycinnamaldehyde, and 2,5-dihydroxy-4-methoxybenzaldehyde. The structures of all compounds were elucidated by spectroscopic analysis.
Assuntos
Antraquinonas/isolamento & purificação , Lignanas/isolamento & purificação , Morinda/química , Antraquinonas/química , Frutas/química , Lignanas/química , Espectrometria de Massas , Conformação Molecular , Ressonância Magnética Nuclear Biomolecular , Rotação Ocular , Ilhas do Pacífico , Espectrofotometria Ultravioleta , Espectroscopia de Infravermelho com Transformada de FourierRESUMO
Four new furanolabdane diterpenes, hypopurin A (1), hypopurin B (2), hypopurin C (3), and hypopurin D (4), together with eight lignans, alpha-O-methylcubebin, beta-O-methylcubebin, hinoquinin, helioxanthin, 7-hydroxyhinokinin, dehydroxycubebin, justicidine E, and (-)-hibalactone, as well as two triterpenes, lupeol and betulin, were isolated from the dried aerial part of Hypoestes purpurea. The structures of 1-4 were elucidated mainly on the basis of NMR and MS. Compound 1 was found to be moderately cytotoxic toward the KB cell line with an IC(50) value of 9.4 microM.
