RESUMO
Two new dolabrane diterpenes, tagalenes J and K (1 and 2), together with eleven known analogues (3 - 13), were isolated from the ethanolic extract of the Chinese mangrove Ceriops tagal. The structures of these compounds were determined by extensive spectroscopic analysis, including 1D-, 2D-NMR and HR-ESI-MS, as well as the comparison with data in the literatures. Cytotoxicities of isolated compounds against MCF-7, SW480, HepG2, HeLa, PANC-1, and A2058 cancer cell lines were also evaluated. Compound 4 exhibited weak cytotoxic activity against SW480, HeLa, and PANC-1 cell lines with IC50 values of 27.7, 22.2, and 17.6 µm, respectively.
Assuntos
Antineoplásicos Fitogênicos/farmacologia , Diterpenos/farmacologia , Rhizophoraceae/química , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/isolamento & purificação , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , China , Diterpenos/química , Diterpenos/isolamento & purificação , Relação Dose-Resposta a Droga , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Espectroscopia de Ressonância Magnética , Conformação Molecular , Relação Estrutura-AtividadeRESUMO
Two new phenylpropanoids, tagalphenylpropanoidins A-B (1-2), together with a known analogue, 2,3,6-trimethoxy-5-(1-propenyl)phenol (3), were isolated from the ethanolic extract of the Chinese mangrove Ceriops tagal. The structures of these compounds were determined by extensive spectroscopic analysis, including 1D and 2D NMR and HR-ESI-MS, as well as the comparison with data in the literature. Compound 3 was discovered from this plant for the first time. Cytotoxicities of the three compounds against MCF-7 and HL-60 cancer cell lines were also evaluated.
