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2.
Pediatr Dermatol ; 35(1): 121-125, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29243341

RESUMO

BACKGROUND/OBJECTIVE: To report our observations from a trial of the short-term effectiveness and safety of topical carteolol hydrochloride drops to treat infantile hemangiomas (IHs). METHODS: From October 2012 to September 2015, the study recruited 349 children with superficial IHs. Participants were randomized to two groups: treatment (n = 224 who received 2% carteolol hydrochloride drops administered to the lesion surface twice daily) and observation (n = 125 who did not receive treatment). Therapy duration was 6 months. RESULTS: The mean age at the beginning of treatment was 3.2 months. Treatment responses were categorized as class 1 (total regression), class 2 (partial regression or controlled growth), or class 3 (no response). Of infants receiving carteolol treatment, 10.7% (24 patients) were categorized as class 1, 72.3% (162 patients) as class 2, and 17.0% (38 patients) as class 3. Of infants in the observation group, 5.6% (7 patients) were categorized as class 1, 25.6% (32 patients) as class 2, and 68.8% (86 patients) as class 3. No adverse effects were noted during treatment. CONCLUSION: Carteolol is an effective, safe topical treatment for superficial IHs. Carteolol may be used to treat proliferative superficial IHs, particularly in infants younger than 6 months.


Assuntos
Antagonistas Adrenérgicos beta/administração & dosagem , Carteolol/administração & dosagem , Hemangioma/tratamento farmacológico , Administração Tópica , Povo Asiático , Feminino , Humanos , Lactente , Masculino , Estudos Prospectivos , Resultado do Tratamento , Conduta Expectante
3.
Pediatr Dermatol ; 30(2): 270-2, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23252446

RESUMO

The study reports the observations after propranolol therapy in 109 Chinese patients with infantile hemangioma. Response to treatment was favorable; 19 (17.4%) showed total regression, 89 (81.7%) partial regression, and 1 (0.9%) had no response. Twenty-three patients (21.1%) had some reactions, possibly due to the medication, but no life-threatening adverse effects were observed.


Assuntos
Antagonistas Adrenérgicos beta/uso terapêutico , Hemangioma/tratamento farmacológico , Propranolol/uso terapêutico , Neoplasias Cutâneas/tratamento farmacológico , Povo Asiático , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Propranolol/efeitos adversos , Estudos Retrospectivos , Resultado do Tratamento
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