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1.
Eur J Med Res ; 28(1): 199, 2023 Jun 29.
Artigo em Inglês | MEDLINE | ID: mdl-37381066

RESUMO

BACKGROUND: Circulating thyroid-stimulating hormone (TSH) levels within the normal reference range can affect the cardiovascular system. The present study investigated the prognostic value of normal TSH levels in patients presenting with acute myocardial infarction (AMI) following percutaneous coronary intervention (PCI). METHODS: Between January 2013 and July 2019, 1240 patients with AMI and normal thyroid function were enrolled and classified according to TSH tertile. The trial endpoint was all-cause mortality. The integrated discrimination index (IDI) and the net reclassification index (NRI) were used to assess the combined predictive values of the TSH levels and the Global Registry of Acute Coronary Events (GRACE) scores. RESULTS: After a median 44.25-month follow-up, 195 individuals died. Even after covariate adjustment by multivariate Cox regression (HR: 1.56; 95% CI 1.08-2.25; P = 0.017), the patients in the third TSH tertile were at the highest risk of all-cause mortality. A subgroup analysis revealed significant interactions between the TSH levels and the GRACE scores (high risk vs. low/medium risk) (P = 0.019). The addition of the TSH levels to the GRACE scores substantially improved the prediction of all-cause mortality, especially for high-risk patients (NRI = 0.239; IDI = 0.044; C-statistic value range 0.649-0.691; all significant). CONCLUSIONS: The third TSH tertile is associated with a higher incidence of all-cause mortality than the first TSH tertile in high-risk patients presenting with AMI after PCI.


Assuntos
Infarto do Miocárdio , Intervenção Coronária Percutânea , Humanos , Intervenção Coronária Percutânea/efeitos adversos , Infarto do Miocárdio/cirurgia , Morte , Sistema de Registros , Tireotropina
2.
Fa Yi Xue Za Zhi ; 29(5): 330-2, 336, 2013 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-24466769

RESUMO

OBJECTIVE: To observe the protein expression of growth associated protein-43 (GAP-43) in midbrain ventral tegmental area in morphine withdrawal rats at different time, and to evaluate the effect of GAP-43 on morphine withdrawal memory. METHODS: Rat models of morphine dependent 1 week, 2 weeks and 4 weeks were established by morphine hydrochloride intraperitoneal injection with increasing doses to establish natural withdrawal. The protein expression of GAP-43 in midbrain ventral tegmental area was observed by immunohistochemical staining and the results were analyzed by Image-Pro Plus 5.1 image analysis system. RESULTS: With prolongation of dependent time, the expression of GAP-43 was decreased then increased in midbrain ventral tegmental area. CONCLUSION: GAP-43 could play a role in morphine withdrawal memory in midbrain ventral tegmental area.


Assuntos
Proteína GAP-43/metabolismo , Dependência de Morfina/metabolismo , Morfina/efeitos adversos , Síndrome de Abstinência a Substâncias/metabolismo , Área Tegmentar Ventral/metabolismo , Animais , Comportamento Animal/efeitos dos fármacos , Modelos Animais de Doenças , Feminino , Imuno-Histoquímica , Masculino , Mesencéfalo/efeitos dos fármacos , Mesencéfalo/metabolismo , Morfina/administração & dosagem , Naloxona/administração & dosagem , Naloxona/farmacologia , Ratos , Ratos Sprague-Dawley , Fatores de Tempo , Área Tegmentar Ventral/efeitos dos fármacos
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