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1.
Indian J Pathol Microbiol ; 58(3): 368-70, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26275268

RESUMO

Melanotic schwannoma is a rare form of pigmented neural tumor commonly arising from the posterior spinal nerves and ganglia. Two variants have been described, psammomatous and nonpsammomatous. 50% of psammomatous tumors are associated with Carney complex. The biologic behavior of the tumor is difficult to predict and slightly over 10% of the tumors follow malignant course. We present a case of psammomatous melanotic schwannoma as part of Carney complex in a 67-year-old male. Clinical examination revealed oral mucosal and abdominal skin pigmentation. Magnetic resonance imaging showed an intradural extramedullary lesion at D8-D12 level. Intraoperative squash smear study showed sheets of spindle cells with abundant intracytoplasmic melanin pigmentation and few psammoma bodies. Based on clinical, radiologic, and histopathological findings with immunohistochemistry correlation a final diagnosis of psammomatous melanotic schwannoma was rendered.


Assuntos
Complexo de Carney/complicações , Complexo de Carney/diagnóstico , Melaninas/análise , Meningioma/diagnóstico , Meningioma/patologia , Neurilemoma/diagnóstico , Neurilemoma/patologia , Idoso , Biomarcadores Tumorais/análise , Complexo de Carney/patologia , Cabeça/diagnóstico por imagem , Histocitoquímica , Humanos , Imuno-Histoquímica , Imageamento por Ressonância Magnética , Masculino , Microscopia , Mucosa Bucal/patologia , Radiografia , Pele/patologia , Neoplasias da Coluna Vertebral/diagnóstico , Neoplasias da Coluna Vertebral/patologia
2.
Indian J Pathol Microbiol ; 57(1): 101-4, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24739844

RESUMO

Pleomorphic xanthoastrocytoma has been considered as an astrocytic tumor with relatively favorable prognosis. It corresponds to WHO Grade-II neoplasm. Recently, several patterns with relatively poor prognosis have been recorded and a new concept of "PXA with anaplastic features" has been proposed. The present case is about a 9-year-old girl who presented with symptoms of recurrent headache, seizures and poor academic performance. MRI revealed left fronto-parietal irregular enhancing mass lesion with callosal involvement and right mid-brain arteriovenous malformation. Clinical and radiological examination was suggestive of a high grade glial neoplasm/PNET. A diagnosis of high grade glial neoplasm was rendered on the squash smears submitted for frozen sections based on the presence of spindle cells, admixed with pleomorphic bizarre, giant cells with multilobated nuclei showing few atypical mitosis and abundant eosinophilic cytoplasm. Frontal craniotomy with debulking of the tumor was performed and permanent sections revealed a biphasic glial neoplasm with spindle cells arranged in fascicles admixed with bizarre multinucleated giant cells showing abundant vacuolated and lipidized cytoplasm, nuclear hyperchromasia with intranuclear inclusions. Eosinophilic granular bodies, mitosis of 7/10 HPF, micro vascular proliferation, necrosis and invasion into the underlying brain parenchyma were noted. With these histomorphological findings a diagnosis of pleomorphic xanthoastrocytoma with anaplastic features was rendered.


Assuntos
Astrocitoma/diagnóstico , Astrocitoma/patologia , Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/patologia , Xantomatose/diagnóstico , Xantomatose/patologia , Astrocitoma/complicações , Astrocitoma/cirurgia , Biomarcadores Tumorais/análise , Neoplasias Encefálicas/cirurgia , Criança , Craniotomia , Feminino , Cabeça/diagnóstico por imagem , Histocitoquímica , Humanos , Imuno-Histoquímica , Imageamento por Ressonância Magnética , Microscopia , Radiografia , Xantomatose/complicações , Xantomatose/cirurgia
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