[Effect of probiotics on the dynamics of gastrointestinal symptoms of food allergy to cow's milk protein in infants].

The problem of food allergy to cow's milk protein in children is highly important. The aim of this study was to estimate the effect of Bifidobacterium lactis BB-12 (1х109 CFU) and Streptococcus thermophilus TH-4 (1х108 CFU) administration on gastrointestinal symptoms of cow's milk allergy in infants. We conducted an open randomized prospective clinical study. 60 infants aged of 3-12 months with the diagnosis of atopic dermatitis and allergy to cow's milk protein were enrolled. Children were divided into 2 groups, one of which received probiotics during 4 weeks. Results were estimated after 4 and 8 weeks of study. We found significant impact on reducing the frequency of constipation in infants who received the probiotics in complex treatment. After 4 weeks of treatment constipation was absent in 85.71% infants who received probiotics as compared to 48.15% in the control group (р=0.02), after 8 weeks the same numbers were 92.86% vs. 62.96% accordingly (p=0.04). Significant differences between the groups were also determined by the incidences of infantile colic through 4 and 8 weeks and on diarrhea through 8 weeks of studies. It is possible to draw a conclusion that administration of probiotics in addition to elimination diet and base treatment to infants with atopic dermatitis and cow's milk allergy improves clinical symptoms of the disease and decreases gastrointestinal clinical manifestations of cow's milk allergy.

[Effect of vitamins A and E on various indices of lipid and protein metabolism in children with perinatal pathology of the central nervous system]. / Vliianie vitaminov A i E na nekotorye pokazateli lipidnogo i belkovogo obmena u detei s perinatal'noi patologiei tsentral'noi nervnoi sistemy.

In children with perinatal pathology of central nervous system content of vitamins A and E was decreased in blood serum. At the same time, some patterns of lipid and protein metabolism were altered. These alterations were especially distinct in pathological conditions accompanied by inflammatory reaction due to infections. Parenteral administration of a complex of vitamins A and E (drug "Aevit") within 2 weeks led to normalization of the content of these vitamins in blood serum. At the same time, the altered patterns of lipid and protein metabolism were normalized.

[Characteristics of the neurotoxic syndrome in children with perinatal pathology of the nervous system]. / Osobennosti neirotoksicheskogo sindroma u detei s perinatal'noi patologiei nervnoi sistemy.

Comprehensive examinations of 100 children aged under 1 year with perinatal pathology of the central nervous system have helped to detect clinical, biochemical, and immunologic features in the course of the neurotoxic syndrome that developed in the presence of vitamins A and E inadequate supply. The efficacy of parenteral aevit in correction of the detected disorders was studied.