[Preliminary data on post-pancreatectomy diabetes mellitus treated by islet-cell autotransplantation]. / Date preliminare despre tratamentul diabetului postpancreatectomie prin autotransplant de insule pancreatice.

The present study describes the first islet autotransplant program in Romania, and the first 3 cases of subtotal pancreatectomy for chronic pancreatitis combined with islet autotransplant. The primary objective was to pain relief by pancreatic resection, but also to preserve the endocrine function by islet autotransplant. Extensive distal pancreatectomy is effective in relieving pain, but should be limited to patients with small duct disease, in whom more conservative methods have failed, because of severe metabolic consequences. Islets were prepared by Liberase digestion of the excised pancreas, and infused unpurified into the portal vein in one case and in the omental pouch and peritoneum in two cases. All patients were relieved of pain, have achieved insulin independence, and positive C peptide levels, but one patient died of a acute bronchopneumonia 60 days post-transplantation. The mean islet yields were 2100 islet equivalents/Kg body weight. Islet autotransplantation can be considered a useful therapeutic option serving to prevent the occurrence of surgically-induced diabetes. The results have indicate that the omental pouch is a viable site for islet autotransplantation, that can accommodate a large tissue volume, is easy to access to implant, and the IBMIR (instant blood mediated inflammatory reaction) may be less severe.

[Measurement and differential demonstration of renal blood flow by computer angiography (author's transl)]. / Die Messung und differenzierte bildliche Darstellung der Nierendurchblutung mit der Computerangiographie.

A new computer-aided x-ray technique is presented which, unlike conventional cine- or video-densitometry, allows a high-resolution quantitative display of the parameters of renal blood flow as so-called 'functional images'. The parameters include blood flow velocity and local perfusion of the kidney. This technique, which we call computer angiography, has decisive advantages; the functional images provide more, and more rapid, information on renal blood flow dynamics than can be obtained by the qualitative evaluation of a series of pictures. The clinical relevance of computer angiography is illustrated by a nephrotic syndrome, polycystic disease and a hypernephroma.

Computer angiography: a new tool for x-ray functional diagnostics.

The method of functional imaging is applied to x-ray angiograms. Functional images are generated by inserting at each point of an x-ray image a computed grey or colour value proportional to a dynamic parameter (such as blood velocity) instead of the recorded x-ray absorption value. For this purpose a new system for angiographic image processing has been developed. First results show that the method which we have called Computer Angiography is a tool to extract more information about the blood dynamics in organs in an easier and faster way than with the conventional angiographic technique.