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Curr Osteoporos Rep ; 22(3): 353-365, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38652430

RESUMO

PURPOSE OF REVIEW: This review aims to provide a theoretical basis and insights for quercetin's clinical application in the prevention and treatment of osteoporosis (OP), analyzing its roles in bone formation promotion, bone resorption inhibition, anti-inflammation, antioxidant effects, and potential mechanisms. RECENT FINDINGS: OP, a prevalent bone disorder, is marked by reduced bone mineral density and impaired bone architecture, elevating the risk of fractures in patients. The primary approach to OP management is pharmacotherapy, with quercetin, a phytochemical compound, emerging as a focus of recent interest. This natural flavonoid exerts regulatory effects on bone marrow mesenchymal stem cells, osteoblasts, and osteoclasts and promotes bone health and metabolic equilibrium via anti-inflammatory and antioxidative pathways. Although quercetin has demonstrated significant potential in regulating bone metabolism, there is a need for further high-quality clinical studies focused on medicinal quercetin.


Assuntos
Antioxidantes , Osteoporose , Quercetina , Quercetina/uso terapêutico , Quercetina/farmacologia , Humanos , Osteoporose/tratamento farmacológico , Antioxidantes/uso terapêutico , Antioxidantes/farmacologia , Osteoclastos/efeitos dos fármacos , Osteogênese/efeitos dos fármacos , Densidade Óssea/efeitos dos fármacos , Anti-Inflamatórios/uso terapêutico , Reabsorção Óssea/tratamento farmacológico , Osteoblastos/efeitos dos fármacos , Células-Tronco Mesenquimais , Conservadores da Densidade Óssea/uso terapêutico , Conservadores da Densidade Óssea/farmacologia
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