RESUMO
4-Pyrazolyl-1,2,3-triazoles can be readily synthesized in a one-pot fashion and moderate yield by employing a consecutive four-component process consisting of a sequentially Pd-Cu-catalyzed alkynylation-cyclocondensation-desilylation-CuAAC process. Most distinctly, (triisopropylsilyl)butadiyne is employed as a four-carbon building block in this one-pot de novo formation of both heterocyclic moieties.
RESUMO
A new highly diastereoselective synthesis of chiral α-substituted allylboronic esters, based on a one-pot, three-step cascade, is presented. The palladium- and acid-cocatalyzed reaction cascade involves a desilylation of a TBS-protected allylic alcohol, borylation, and addition of an allyl group to an aldehyde. Herein we present the first application of a TBS-protected allylic alcohol in a palladium-catalyzed borylation/allylation reaction.