RESUMO
The efficacies of diloxanide furoate, beta-cyclodextrin and a cyclodextrin inclusion complex against Cryptosporidium parvum were evaluated in a suckling murine model. Efficacy was established by numbers of oocysts recovered from the intestinal tract of mice on day 7 postinfection. The level of infection in treated mice was significantly lower than in control mice and, surprisingly, the most efficacious treatment was beta-cyclodextrin, an excipient used in pharmaceutical technology.
Assuntos
Amebicidas/uso terapêutico , Criptosporidiose/tratamento farmacológico , Cryptosporidium parvum/isolamento & purificação , Ciclodextrinas/uso terapêutico , Furanos/uso terapêutico , beta-Ciclodextrinas , Animais , Bovinos , Criptosporidiose/parasitologia , Cryptosporidium parvum/fisiologia , Modelos Animais de Doenças , Portadores de Fármacos , Quimioterapia Combinada , Excipientes , Camundongos , Contagem de Ovos de ParasitasRESUMO
Spherical pellets containing 5% of triamcinolone acetonide (TA) were formed by extrusion/spheronization following formulation with microcrystalline cellulose (MCC) and/or a hydrophilic excipient (lactose, sodium carboxymethylcellulose or beta-cyclodextrin, beta-CD). Their suitability for coating, with a view to colonic drug delivery, was assessed in terms of their size, sphericity and dissolution test response. Best results were afforded by 5:90:5 MCC-beta-CD-TA pellets obtained by complexation of TA with beta-CD prior to addition of MCC, extrusion and spheronization.
