Crossing borders in Alzheimer's disease: A T cell's perspective.

Alzheimer's disease (AD) is the most common form of dementia affecting millions of people worldwide. While different immunotherapies are imminent, currently only disease-modifying medications are available and a cure is lacking. Over the past decade, immunological interfaces of the central nervous system (CNS) and their role in neurodegenerative diseases received increasing attention. Specifically, emerging evidence shows that subsets of circulating CD8+ T cells cross the brain barriers and associate with AD pathology. To gain more insight into how the adaptive immune system is involved in disease pathogenesis, we here provide a comprehensive overview of the contribution of T cells to AD pathology, incorporating changes at the brain barriers. In addition, we review studies that provide translation of these findings by targeting T cells to combat AD pathology and cognitive decline. Importantly, these data show that immunological changes in AD are not confined to the CNS and that AD-associated systemic immune changes appear to affect brain homeostasis.

[Resolution of ascites after successful balloon dilatation of cortriatriatum dexter in a dog]. / Verdwijnen van ascites na succesvolle ballondilatatie van een cor triatriatum dexter bij een hond.

A 9-month-old male American Cocker Spaniel was examined for progressive abdominal distension, tachypnoea, and decreased appetite. Physical examination revealed signs of congestion in the caudal body half only (ascites, congested saphenic vein), and abdominocentesis yielded a modified transudate. Echocardiography revealed an abnormal membrane in the right atrium and cor triatriatum dexter was diagnosed; the diagnosis was confirmed by cardiac catheterization. Successful treatment consisted of balloon dilatation of the pinpoint opening in the abnormal membrane. The dog recovered well, with the ascites resolving within a week, and its further development was normal.

''NODUS''-a sensitive new instrument for analyzing the composition of surfaces.

A novel type of ion-scattering spectrometer for analyzing the composition of surfaces is described. By means of a specially designed cylindrical mirror analyzer the sensitivity of the instrument is increased by two or three orders of magnitude as compared with that of equipment used hitherto. The increased sensitivity allows analyses to be performed using extremely low ion doses. Under these conditions, destruction of the surface is negligible. The use of a differential pumping system guarantees UHV conditions at the target, thus minimizing contamination.